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Applications of Polyhydroxyalkanoates and Their Metabolites as Drug Carriers

  • Vipin Chandra Kalia
  • Subhasree Ray
  • Sanjay K. S. Patel
  • Mamtesh Singh
  • Gajendra Pratap Singh
Chapter

Abstract

Drug delivery systems based on biodegradable biomaterials have proved attractive to improve their efficacy. Biopolymers such as Polyhydroxyalkanoates (PHAs) have the potential to be used as materials for preparing nanoparticles as drug carriers. This review describes the recent developments in drug delivery systems based on PHAs derived from microbial fermentations. Various strategies for the synthesis of microspheres, encapsulations, nano-constructs, have been presented, with their potential applications in medical domain.

Keywords

Polyhydroxyalkanoates Nanoparticles Drug carriers Bacteria 

Notes

Acknowledgement

This work was supported by Brain Pool grant (NRF-2018H1D3A2001746) by National Research Foundation of Korea (NRF) to work at Konkuk University.

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© Springer Nature Singapore Pte Ltd. 2019

Authors and Affiliations

  • Vipin Chandra Kalia
    • 1
  • Subhasree Ray
    • 2
    • 3
  • Sanjay K. S. Patel
    • 1
  • Mamtesh Singh
    • 4
  • Gajendra Pratap Singh
    • 5
  1. 1.Department of Chemical EngineeringKonkuk UniversitySeoulRepublic of Korea
  2. 2.Microbial Biotechnology and GenomicsCSIR – Institute of Genomics and Integrative Biology (IGIB)DelhiIndia
  3. 3.Academy of Scientific & Innovative Research (AcSIR)New DelhiIndia
  4. 4.Department of Zoology, Gargi CollegeUniversity of DelhiDelhiIndia
  5. 5.Mathematical Sciences and Interdisciplinary Research Lab (MathSciIntR-Lab), School of Computational and Integrative SciencesJawaharlal Nehru UniversityNew DelhiIndia

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