Strategy for Biosynthesis of Polyhydroxyalkonates Polymers/Copolymers and Their Application in Drug Delivery

  • Shashi Kant Bhatia
  • Puneet Wadhwa
  • Ravi Kant Bhatia
  • Sanjay Kumar Singh Patel
  • Yung-Hun Yang


Drug delivery technology is an emerging field to improve health, and there is considerable interest to use biodegradable biomaterial in drug delivery. Polyhydroxyalkonate (PHA) is a natural origin polymer and getting attention for drug delivery due to its biodegradability and biocompatible properties. PHA with different monomer compositions has different physical and chemical properties which further affect drug loading and release. PHA polymers of different monomer composition can be synthesized using various approaches such as metabolic engineering, precursor feedings, etc. PHA polymers in their intrinsic form or block copolymers forms can be used to prepare different structure such as microsphere, naonparticles, nanofiber, and scaffold, etc. Drug and pharmaceutically active molecule loaded PHA material carrier can be delivered through oral, intravenous or subcutaneous route. Selection of drug delivery route depends on the nature and required dose of drug. Drug release from the polymeric material occurs through osmosis, diffusion or biodegradation mechanism. Composition of polymeric material affects its drug release behavior. This chapter discusses the various trends in PHA polymer production and their application in drug delivery.


Polyhydroxyalkonates Polymers Copolymers Drug delivery 



The authors acknowledge the KU Research Professor Program of Konkuk University, Seoul, South Korea for providing financial support to Dr. Shashi Kant Bhatia.


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© Springer Nature Singapore Pte Ltd. 2019

Authors and Affiliations

  • Shashi Kant Bhatia
    • 1
  • Puneet Wadhwa
    • 2
  • Ravi Kant Bhatia
    • 3
  • Sanjay Kumar Singh Patel
    • 4
  • Yung-Hun Yang
    • 1
  1. 1.Department of Biological Engineering, College of EngineeringKonkuk UniversitySeoulRepublic of Korea
  2. 2.Department of Oral and Maxillofacial Surgery, College of Dental Science, Guro HospitalKorea UniversitySeoulRepublic of Korea
  3. 3.Department of BiotechnologyHimachal Pradesh UniversityShimlaIndia
  4. 4.Department of Chemical EngineeringKonkuk UniversitySeoulRepublic of Korea

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