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Poor Early Growth and Age-Associated Disease

  • Jane L. Tarry-Adkins
  • Susan E. Ozanne
Chapter
Part of the Subcellular Biochemistry book series (SCBI, volume 91)

Abstract

The prevalence of age-associated disease is increasing at a striking rate globally and there is evidence to suggest that the ageing process may actually begin before birth. It has been well-established that the status of both the maternal and early postnatal environments into which an individual is exposed can have huge implications for the risk of developing age-associated disease, including cardiovascular disease (CVD), type-2 diabetes (T2D) and obesity in later life. Therefore, the dissection of underlying molecular mechanisms to explain this phenomenon, known as ‘developmental programming’ is a highly investigated area of research. This book chapter will examine the epidemiological evidence and the animal models of suboptimal maternal and early postnatal environments and will discuss the progress being made in the development of safe and effective intervention strategies which ultimately could target those ‘programmed’ individuals who are known to be at-risk of age-associated disease.

Keywords

Developmental programming Ageing Disease Mechanisms 

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Copyright information

© Springer Nature Singapore Pte Ltd. 2019

Authors and Affiliations

  • Jane L. Tarry-Adkins
    • 1
  • Susan E. Ozanne
    • 1
  1. 1.University of Cambridge Metabolic Research Laboratories and MRC Metabolic Diseases Unit, Wellcome Trust-MRC Institute of Metabolic Science, Addenbrooke’s Treatment Centre, Addenbrooke’s HospitalCambridgeUK

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