Advertisement

Starch-Based DDSs with Physiological Interactions

  • Jin ChenEmail author
  • Ling Chen
  • Fengwei Xie
  • Xiaoxi Li
Chapter

Abstract

Drug delivery systems (DDSs) are designed to be able to precisely control the release rate and/or target drugs to specific body sites. However, the successful application of DDSs could be limited in the clinical application due to the complicated environment of the human body. This can be exampled by the short circulation time and low targeting efficiency of target-specific DDSs induced by the RES recognition, or low bioavailability of drugs caused by short residence time of transmucosal DDSs at the site of absorption. Regarding this, in this chapter, strategies to improve the performance and bioavailability of starch-based DDSs are discussed. Target-specific starch-based DDSs can be achieved by passive and active targeting. Another possible strategy is the physical targeting of drugs by external stimuli, such as magnetic field. Also, the role of starch and its derivatives in transmucosal DDSs to improve the bioavailability of drugs by interacting with the absorbing mucosa or prolonging the residence time of drugs in the absorbing tissues are highlighted.

Keywords

Transmucosal starch-based drug delivery system Bioadhesion Widening tight junction effect Target-specific starch-based drug delivery system Blood hematocompatibility Passive targeting Active targeting External targeting 

References

  1. Aderem A, Underhill DM (1999) Mechanisms of phagocytosis in macrophages. Annu Rev Immunol 17:593–623CrossRefGoogle Scholar
  2. American Psychiatric A (1988) AIDS policy: guidelines for inpatient psychiatric units. Am J Psychiatry 145:542.  https://doi.org/10.1155/2010/409320Google Scholar
  3. Ahmad MZ, Akhter S, Anwar M, Ahmad FJ (2012a) Assam Bora rice starch based biocompatible mucoadhesive microsphere for targeted delivery of 5-fluorouracil in colorectal cancer. Mol Pharm 9:2986–2994.  https://doi.org/10.1021/mp300289yCrossRefGoogle Scholar
  4. Ahmad MZ, Akhter S, Ahmad I, Singh A, Anwar M, Shamim M, Ahmad FJ (2012b) In vitro and in vivo evaluation of Assam Bora rice starch-based bioadhesive microsphere as a drug carrier for colon targeting. Expert Opin Drug Deliv 9:141–149.  https://doi.org/10.1517/17425247.2012.633507CrossRefGoogle Scholar
  5. Ahmad MZ, Akhter S, Anwar M, Kumar A, Rahman M, Talasaz AH, Ahmad FJ (2013) Colorectal cancer targeted Irinotecan-Assam Bora rice starch based microspheres: a mechanistic, pharmacokinetic and biochemical investigation. Drug Dev Ind Pharm 39:1936–1943.  https://doi.org/10.3109/03639045.2012.719906CrossRefGoogle Scholar
  6. Ali AE-H, AlArifi A (2009) Characterization and in vitro evaluation of starch based hydrogels as carriers for colon specific drug delivery systems. Carbohydr Polym 78:725–730Google Scholar
  7. Anderberg EK, Nyström C, Artursson P (1992) Epithelial transport of drugs in cell culture. VII: Effects of pharmaceutical surfactant excipients and bile acids on transepithelial permeability in monolayers of human intestinal epithelial (Caco-2) cells. J Pharm Sci 81:879–887CrossRefGoogle Scholar
  8. Armstrong JK, Hempel G, Koling S, Chan LS, Fisher T, Meiselman HJ, Garratty G (2007) Antibody against poly (ethylene glycol) adversely affects PEG-asparaginase therapy in acute lymphoblastic leukemia patients. Cancer 110:103–111CrossRefGoogle Scholar
  9. Artursson P, Arro E, Edman P, Ericsson JL, Sjöholm I (1987) Biodegradable microspheres V: stimulation of macrophages with microparticles made of various polysaccharides. J Pharm Sci 76:127–133CrossRefGoogle Scholar
  10. Baier G, Baumann D, Siebert JM, Musyanovych A, Mailander V, Landfester K (2012) Suppressing unspecific cell uptake for targeted delivery using hydroxyethyl starch nanocapsules. Biomacromolecules 13:2704–2715.  https://doi.org/10.1021/bm300653vCrossRefPubMedGoogle Scholar
  11. Baillie AJ, Coombs GH, Dolan TF, Hunter CA, Laakso T, Sjöholm I, Stjärnkvist P (1987) Biodegradable microspheres: polyacryl starch microparticles as a delivery system for the antileishmanial drug, sodium stibogluconate. J Pharm Pharmacol 39:832–835.  https://doi.org/10.1111/j.2042-7158.1987.tb05126.xCrossRefGoogle Scholar
  12. Behzadi S et al (2017) Cellular uptake of nanoparticles: journey inside the cell. Chem Soc Rev 46:4218–4244.  https://doi.org/10.1039/c6cs00636aCrossRefPubMedPubMedCentralGoogle Scholar
  13. Bergemann C, Muller-Schulte D, Oster J, a Brassard L, Lubbe AS (1999) Magnetic ion-exchange nano- and microparticles for medical, biochemical and molecular biological applications. J Magn Magn Mater 194:45–52.  https://doi.org/10.1016/s0304-8853(98)00554-xCrossRefGoogle Scholar
  14. Bie P, Chen L, Li X, Li L (2016) Characterization of concanavalin A-conjugated resistant starch acetate bioadhesive film for oral colon-targeting microcapsule delivery system. Ind Crops Prod 84:320–329.  https://doi.org/10.1016/j.indcrop.2016.02.023CrossRefGoogle Scholar
  15. Biswas N, Sahoo RK (2016) Tapioca starch blended alginate mucoadhesive-floating beads for intragastric delivery of Metoprolol Tartrate. Int J Biol Macromol 83:61–70.  https://doi.org/10.1016/j.ijbiomac.2015.11.039CrossRefGoogle Scholar
  16. Björk E, Edman P (1988) Degradable starch microspheres as a nasal delivery system for insulin. Int J Pharm 47:233–238.  https://doi.org/10.1016/0378-5173(88)90236-0CrossRefGoogle Scholar
  17. Björk E, Edman P (1990) Characterization of degradable starch microspheres as a nasal delivery system for drugs. Int J Pharm 62:187–192.  https://doi.org/10.1016/0378-5173(90)90232-SCrossRefGoogle Scholar
  18. Bjork E, Isaksson U, Edman P, Artursson P (1995) Starch microspheres induce pulsatile delivery of drugs and peptides across the epithelial barrier by reversible separation of the tight junctions. J Drug Target 2:501–507.  https://doi.org/10.3109/10611869509015920CrossRefPubMedGoogle Scholar
  19. Boddupalli BM, Mohammed ZNK, Nath RA, Banji D (2010) Mucoadhesive drug delivery system: an overview. J Adv Pharm Technol Res 1:381–387.  https://doi.org/10.4103/0110-5558.76436CrossRefPubMedPubMedCentralGoogle Scholar
  20. Bye W, Allan C, Trier J (1984) Structure, distribution, and origin of M cells in Peyer’s patches of mouse ileum. Gastroenterology 86:789–801Google Scholar
  21. Campbell K, Craig DQ, McNally T (2008) Poly (ethylene glycol) layered silicate nanocomposites for retarded drug release prepared by hot-melt extrusion. Int J Pharm 363:126–131CrossRefGoogle Scholar
  22. Chadha H, DeLuca PP (1998) Effect of polytyrosine on the hydrophobicity of hydroxyethyl starch microspheres. Pharm Dev Technol 3:597–606CrossRefGoogle Scholar
  23. Chertok B, Cole AJ, David AE, Yang VC (2010) Comparison of electron spin resonance spectroscopy and inductively-coupled plasma optical emission spectroscopy for biodistribution analysis of iron-oxide nanoparticles. Mol Pharm 7:375–385CrossRefGoogle Scholar
  24. Codd JE, Deasy PB (1998) Formulation development and in vivo evaluation of a novel bioadhesive lozenge containing a synergistic combination of antifungal agents. Int J Pharm 173:13-24.  https://doi.org/10.1016/s0378-5173(98)00228-2.CrossRefGoogle Scholar
  25. Cole AJ, David AE, Wang J, Galbán CJ, Yang VC (2011a) Magnetic brain tumor targeting and biodistribution of long-circulating PEG-modified, cross-linked starch-coated iron oxide nanoparticles. Biomaterials 32:6291–6301.  https://doi.org/10.1016/j.biomaterials.2011.05.024CrossRefGoogle Scholar
  26. Cole AJ, David AE, Wang J, Galban CJ, Hill HL, Yang VC (2011b) Polyethylene glycol modified, cross-linked starch-coated iron oxide nanoparticles for enhanced magnetic tumor targeting. Biomaterials 32:2183–2193.  https://doi.org/10.1016/j.biomaterials.2010.11.040CrossRefGoogle Scholar
  27. Constantin M, Fundueanu G, Cortesi R, Esposito E, Nastruzzi C (2003) Aminated polysaccharide microspheres as DNA delivery systems. Drug Delivery 10:139-149.  https://doi.org/10.1080/10717540390215537
  28. Critchley H, Davis SS, Farraj NF, Illum L (1994) Nasal absorption of desmopressin in rats and sheep. Effect of a bioadhesive microsphere delivery system. J Pharm Pharmacol 46:651–656CrossRefGoogle Scholar
  29. Dandekar P, Jain R, Stauner T, Loretz B, Koch M, Wenz G, Lehr C-M (2012) A hydrophobic starch polymer for nanoparticle-mediated delivery of docetaxel. Macromol Biosci 12:184–194.  https://doi.org/10.1002/mabi.201100244CrossRefGoogle Scholar
  30. Darroudi M, Hakimi M, Goodarzi E, Oskuee RK (2014) Superparamagnetic iron oxide nanoparticles (SPIONs): green preparation, characterization and their cytotoxicity effects. Ceram Int 40:14641–14645.  https://doi.org/10.1016/j.ceramint.2014.06.051CrossRefGoogle Scholar
  31. Dobrovolskaia MA, Aggarwal P, Hall JB, McNeil SE (2008) Preclinical studies to understand nanoparticle interaction with the immune system and its potential effects on nanoparticle biodistribution. Mol Pharm 5:487–495CrossRefGoogle Scholar
  32. Edman P, Björk E, Rydén L (1992) Microspheres as a nasal delivery system for peptide drugs. J Controlled Release 21:165–172.  https://doi.org/10.1016/0168-3659(92)90018-MCrossRefGoogle Scholar
  33. Engelberth SA, Hempel N, Bergkvist M (2015) Chemically Modified Dendritic Starch: A Novel Nanomaterial for siRNA Delivery. Bioconjugate Chem 26:1766–1774CrossRefGoogle Scholar
  34. Fathi M, Entezami AA (2014) Stable aqueous dispersion of magnetic iron oxide core-shell nanoparticles prepared by biocompatible maleate polymers. Surf Interface Anal 46:145–151.  https://doi.org/10.1002/sia.5362CrossRefGoogle Scholar
  35. Fichter M, Baier G, Dedters M, Pretsch L, Pietrzak-Nguyen A, Landfester K, Gehring S (2013) Nanocapsules generated out of a polymeric dexamethasone shell suppress the inflammatory response of liver macrophages. Nanomed Nanotechnol Biol Med 9:1223–1234.  https://doi.org/10.1016/j.nano.2013.05.005CrossRefGoogle Scholar
  36. Fichter M et al (2015) Monophosphoryl lipid A coating of hydroxyethyl starch nanocapsules drastically increases uptake and maturation by dendritic cells while minimizing the adjuvant dosage. Vaccine 33:838–846.  https://doi.org/10.1016/j.vaccine.2014.12.072CrossRefPubMedGoogle Scholar
  37. Frei E, Canellos GP (1980) Dose: a critical factor in cancer chemotherapy. Am J Med 69:585–594CrossRefGoogle Scholar
  38. Freichels H, Wagner M, Okwieka P, Meyer RG, Mailander V, Landfester K, Musyanovych A (2013) (Oligo)mannose functionalized hydroxyethyl starch nanocapsules: en route to drug delivery systems with targeting properties. J Mater Chem B 1:4338–4348.  https://doi.org/10.1039/c3tb20138dCrossRefGoogle Scholar
  39. Geresh S, Gdalevsky GY, Gilboa I, Voorspoels J, Remon JP, Kost J (2004) Bioadhesive grafted starch copolymers as platforms for peroral drug delivery: a study of theophylline release. J Controlled Release 94:391–399CrossRefGoogle Scholar
  40. Goszczynski TM, Filip-Psurska B, Kempinska K, Wietrzyk J, Boratynski J (2014) Hydroxyethyl starch as an effective methotrexate carrier in anticancer therapy. Pharmacol Res & Perspect 2:e00047–e00047.  https://doi.org/10.1002/prp2.47CrossRefGoogle Scholar
  41. Güler MA, Gök MK, Figen AK, Özgümüş S (2015) Swelling, mechanical and mucoadhesion properties of Mt/starch-g-PMAA nanocomposite hydrogels. Appl Clay Sci 112:44–52CrossRefGoogle Scholar
  42. Hallenbeck JM et al (1986) Polymorphonuclear leukocyte accumulation in brain regions with low blood flow during the early postischemic period. Stroke 17:246–253.  https://doi.org/10.1161/01.str.17.2.246CrossRefGoogle Scholar
  43. Heritage PL, Loomes LM, Jianxiong J, Brook MA, Underdown BJ, McDermott MR (1996) Novel polymer-grafted starch microparticles for mucosal delivery of vaccines. Immunology 88:162–168.  https://doi.org/10.1046/j.1365-2567.1996.d01-639.xCrossRefPubMedPubMedCentralGoogle Scholar
  44. Heritage PL, Underdown BJ, Brook MA, McDermott MR (1998) Oral administration of polymer-grafted starch microparticles activates gut-associated lymphocytes and primes mice for a subsequent systemic antigen challenge. Vaccine 16:2010–2017.  https://doi.org/10.1016/s0264-410x(98)00085-1CrossRefPubMedGoogle Scholar
  45. Hoffmann S, Caysa H, Kuntsche J, Kreideweiß P, Leimert A, Mueller T, Mäder K (2013) Carbohydrate plasma expanders for passive tumor targeting: in vitro and in vivo studies. Carbohydr Polym 95:404–413CrossRefGoogle Scholar
  46. Höök F, Rodahl M, Kasemo B, Brzezinski P (1998) Structural changes in hemoglobin during adsorption to solid surfaces: effects of pH, ionic strength, and ligand binding. Proc Nat Acad Sci 95:12271–12276CrossRefGoogle Scholar
  47. Illum L, Jørgensen H, Bisgaard H, Krogsgaard O, Rossing N (1987) Bioadhesive microspheres as a potential nasal drug delivery system. Int J Pharm 39:189–199.  https://doi.org/10.1016/0378-5173(87)90216-xCrossRefGoogle Scholar
  48. Illum L, Fisher AN, Jabbal-Gill I, Davis SS (2001) Bioadhesive starch microspheres and absorption enhancing agents act synergistically to enhance the nasal absorption of polypeptides. Int J Pharm 222:109–119.  https://doi.org/10.1016/s0378-5173(01)00708-6CrossRefGoogle Scholar
  49. Jain AK, Khar RK, Ahmed FJ, Diwan PV (2008) Effective insulin delivery using starch nanoparticles as a potential trans-nasal mucoadhesive carrier. Eur J Pharm Biopharm 69:426-435.  https://doi.org/10.1016/j.ejpb.2007.12.001CrossRefGoogle Scholar
  50. Jain S, Bajpai A (2013) Designing polyethylene glycol (PEG)–plasticized membranes of poly (vinyl alcohol-g-methyl methacrylate) and investigation of water sorption and blood compatibility behaviors. Des Monomers Polym 16:436–446CrossRefGoogle Scholar
  51. Jain R et al (2011) Enhanced cellular delivery of idarubicin by surface modification of propyl starch nanoparticles employing pteroic acid conjugated polyvinyl alcohol. Int J Pharm 420:147–155.  https://doi.org/10.1016/j.ijpharm.2011.08.030CrossRefGoogle Scholar
  52. Jie Z, Jian Z, Allan ED, Victor CY (2013) Magnetic tumor targeting of β-glucosidase immobilized iron oxide nanoparticles. Nanotechnology 24:375102CrossRefGoogle Scholar
  53. Kelemen LE (2006) The role of folate receptor α in cancer development, progression and treatment: cause, consequence or innocent bystander? Int J Cancer 119:243–250CrossRefGoogle Scholar
  54. Kim DK, Zhang Y, Voit W, Rao KV, Muhammed M (2001) Synthesis and characterization of surfactant-coated superparamagnetic monodispersed iron oxide nanoparticles. J Magn Magn Mater 225:30–36.  https://doi.org/10.1016/S0304-8853(00)01224-5CrossRefGoogle Scholar
  55. Kim DK, Mikhaylova M, Zhang Y, Muhammed M (2003) Protective coating of superparamagnetic iron oxide nanoparticles. Chem Mater 15:1617–1627.  https://doi.org/10.1021/cm021349jCrossRefGoogle Scholar
  56. Kreuter J (2013) Mechanism of polymeric nanoparticle-based drug transport across the blood-brain barrier (BBB). J Microencapsul 30:49–54CrossRefGoogle Scholar
  57. Kumar P, Senthamilselvi S, Govindaraju M (2014) Phloroglucinol-encapsulated starch biopolymer: preparation, antioxidant and cytotoxic effects on HepG2 liver cancer cell lines. RSC Adv 4:26787–26795.  https://doi.org/10.1039/c4ra02621gCrossRefGoogle Scholar
  58. Kumari S, Mg S, Mayor S (2010) Endocytosis unplugged: multiple ways to enter the cell. Cell Res 20:256.  https://doi.org/10.1038/cr.2010.19CrossRefGoogle Scholar
  59. Kwag DS, Oh KT, Lee ES (2014) Facile synthesis of multilayered polysaccharidic vesicles. J Controlled Release 187:83–90.  https://doi.org/10.1016/j.jconrel.2014.05.032CrossRefGoogle Scholar
  60. Laakso T, Artursson P, Sjoholm I (1986) Biodegradable microspheres IV: factors affecting the distribution and degradation of polyacryl starch microparticles. J Pharm Sci 75:962–967CrossRefGoogle Scholar
  61. Larhed A, Stertman L, Edvardsson E, Sjöholm I (2004) Starch microparticles as oral vaccine adjuvant: antigen-dependent uptake in mouse intestinal mucosa. J Drug Target 12:289–296.  https://doi.org/10.1080/1061186042000223662CrossRefPubMedGoogle Scholar
  62. Lee MJ-E et al (2010) Rapid pharmacokinetic and biodistribution studies using cholorotoxin-conjugated iron oxide nanoparticles: a novel non-radioactive method. PLOS ONE 5:e9536.  https://doi.org/10.1371/journal.pone.0009536CrossRefGoogle Scholar
  63. Lefnaoui S, Moulai-Mostefa N (2011) Formulation and in vitro evaluation of kappa-carrageenan-pregelatinized starch-based mucoadhesive gels containing miconazole. Starch - Stärke 63:512–521.  https://doi.org/10.1002/star.201000141CrossRefGoogle Scholar
  64. Lefnaoui S, Moulai-Mostefa N (2014) Investigation and optimization of formulation factors of a hydrogel network based on kappa carrageenan–pregelatinized starch blend using an experimental design. Colloids Surf A 458:117–125.  https://doi.org/10.1016/j.colsurfa.2014.01.007CrossRefGoogle Scholar
  65. Lemieux M, Bouchard F, Gosselin P, Paquin J, Mateescu MA (2011) The NCI-N87 cell line as a gastric epithelial barrier model for drug permeability assay. Biochem Biophys Res Commun 412:429–434CrossRefGoogle Scholar
  66. Lemieux M, Gosselin P, Mateescu MA (2015) Carboxymethyl starch mucoadhesive microspheres as gastroretentive dosage form. Int J Pharm 496:497–508CrossRefGoogle Scholar
  67. Li G et al (2014a) Hydroxyethyl starch conjugates for improving the stability, pharmacokinetic behavior and antitumor activity of 10-hydroxy camptothecin. Int J Pharm 471:234–244.  https://doi.org/10.1016/j.ijpharm.2014.05.038CrossRefGoogle Scholar
  68. Li J et al (2014b) A multifunctional polymeric nanotheranostic system delivers doxorubicin and imaging agents across the blood-brain barrier targeting brain metastases of breast cancer. ACS Nano 8:9925–9940.  https://doi.org/10.1021/nn501069cCrossRefGoogle Scholar
  69. Li K et al (2015) Mulberry-like dual-drug complicated nanocarriers assembled with apogossypolone amphiphilic starch micelles and doxorubicin hyaluronic acid nanoparticles for tumor combination and targeted therapy. Biomaterials 39:131–144.  https://doi.org/10.1016/j.biomaterials.2014.10.073CrossRefGoogle Scholar
  70. Li G, Cai C, Qi Y, Tang X (2016) Hydroxyethyl starch–10-hydroxy camptothecin conjugate: synthesis, pharmacokinetics, cytotoxicity and pharmacodynamics research. Drug Deliv 23:277–284CrossRefGoogle Scholar
  71. Likhitkar S, Bajpai AK (2012) Magnetically controlled release of cisplatin from superparamagnetic starch nanoparticles. Carbohydr Polym 87:300–308.  https://doi.org/10.1016/j.carbpol.2011.07.053CrossRefGoogle Scholar
  72. Likhitkar S, Bajpai AK (2014) An in vitro experimental approach to study magnetically targeted release of methotrexate from superparamagnetic starch nanocarriers. Int J Polym Mater Polym Biomater 63:941–950.  https://doi.org/10.1080/00914037.2014.886232CrossRefGoogle Scholar
  73. Lin J, Zhang H, Chen Z, Zheng Y (2010) Penetration of lipid membranes by gold nanoparticles: insights into cellular uptake, cytotoxicity, and their relationship. ACS Nano 4:5421–5429CrossRefGoogle Scholar
  74. Liu Q, Yang X, Xu H, Pan K, Yang Y (2013) Novel nanomicelles originating from hydroxyethyl starch-g-polylactide and their release behavior of docetaxel modulated by the PLA chain length. Eur Polym J 49:3522-3529.  https://doi.org/10.1016/j.eurpolymj.2013.08.012CrossRefGoogle Scholar
  75. Lu W, Shen Y, Xie A, Zhang W (2013) Preparation and protein immobilization of magnetic dialdehyde starch nanoparticles. J Phys Chem B 117:3720–3725.  https://doi.org/10.1021/jp3110908CrossRefPubMedGoogle Scholar
  76. Madhav NS, Shakya AK, Shakya P, Singh K (2009) Orotransmucosal drug delivery systems: a review. J Controlled Release 140:2–11CrossRefGoogle Scholar
  77. Mailman D, Womack WA, Kvietys PR, Granger DN (1990) Villous motility and unstirred water layers in canine intestine. Am J Physiol 258:G238–G246.  https://doi.org/10.1152/ajpgi.1990.258.2.G238CrossRefPubMedGoogle Scholar
  78. Mallick SP et al (2016) An in-depth analysis of the mechanical, electrical, and drug release properties of gelatin–starch phase-separated hydrogels. Polym Plast Technol Eng 55:1731–1742.  https://doi.org/10.1080/03602559.2016.1171873CrossRefGoogle Scholar
  79. Mao SR, Chen JM, Wei ZP, Liu H, Bi DZ (2004) Intranasal administration of melatonin starch microspheres. Int J Pharm 272:37–43.  https://doi.org/10.1016/j.ijpharm.2003.11.028CrossRefPubMedGoogle Scholar
  80. Marto J et al (2016) A quality by design (QbD) approach on starch-based nanocapsules: a promising platform for topical drug delivery. Colloids Surf B Biointerfaces 143:177–185.  https://doi.org/10.1016/j.colsurfb.2016.03.039CrossRefGoogle Scholar
  81. McDermott MR, Heritage PL, Bartzoka V, Brook MA (1998) Polymer-grafted starch microparticles for oral and nasal immunization. Immunol Cell Biol 76:256–262.  https://doi.org/10.1046/j.1440-1711.1998.00743.xCrossRefPubMedGoogle Scholar
  82. Minimol PF, Paul W, Sharma CP (2013) PEGylated starch acetate nanoparticles and its potential use for oral insulin delivery. Carbohydr Polym 95:1–8.  https://doi.org/10.1016/j.carbpol.2013.02.021CrossRefPubMedGoogle Scholar
  83. Moghimi SM, Hunter AC, Murray JC (2001) Long-circulating and target-specific nanoparticles: theory to practice. Pharmacol Rev 53:283–318Google Scholar
  84. Momeni A, Mohammadi MH (2009) Respiratory delivery of theophylline by size-targeted starch microspheres for treatment of asthma. J Microencapsul 26:701–710.  https://doi.org/10.3109/02652040802685043CrossRefPubMedGoogle Scholar
  85. Montgomery PC, Rafferty DE (1998) Induction of secretory and serum antibody responses following oral administration of antigen with bioadhesive degradable starch microparticles. Oral Microbiol Immunol 13:139–149.  https://doi.org/10.1111/j.1399-302X.1998.tb00725.xCrossRefGoogle Scholar
  86. Mortazavi SA, Smart JD (1993) An investigation into the role of water movement and mucus gel dehydration in mucoadhesion. J Controlled Release 25:197–203CrossRefGoogle Scholar
  87. Nahar K, Absar S, Patel B, Ahsan F (2014) Starch-coated magnetic liposomes as an inhalable carrier for accumulation of fasudil in the pulmonary vasculature. Int J Pharm 464:185–195.  https://doi.org/10.1016/j.ijpharm.2014.01.007CrossRefPubMedPubMedCentralGoogle Scholar
  88. Narayanan D, Nair S, Menon D (2015) A systematic evaluation of hydroxyethyl starch as a potential nanocarrier for parenteral drug delivery. Int J Biol Macromol 74:575–584.  https://doi.org/10.1016/j.ijbiomac.2014.12.012CrossRefPubMedGoogle Scholar
  89. Newman JP (1987) Reaction to punishment in extraverts and psychopaths: Implications for the impulsive behavior of disinhibited individuals. J Res Pers 21:464–480CrossRefGoogle Scholar
  90. Noga M et al (2013) The effect of molar mass and degree of hydroxyethylation on the controlled shielding and deshielding of hydroxyethyl starch-coated polyplexes. Biomaterials 34:2530–2538.  https://doi.org/10.1016/j.biomaterials.2012.12.025CrossRefGoogle Scholar
  91. Noga M, Edinger D, Wagner E, Winter G, Besheer A (2014) Characterization and compatibility of hydroxyethyl starch-polyethylenimine copolymers for DNA delivery. J Biomater Sci Polym Ed 25:855–871.  https://doi.org/10.1080/09205063.2014.910152CrossRefGoogle Scholar
  92. O’Hagan DT, Rafferty D, Wharton S, Illum L (1993) Intravaginal immunization in sheep using a bioadhesive microsphere antigen delivery system Vaccine 11:660-664.  https://doi.org/10.1016/0264-410X(93)90313-MCrossRefGoogle Scholar
  93. Oliveira Cardoso VM, Stringhetti Ferreira Cury B, Evangelista RC, Daflon Gremiao MP (2016) Development and characterization of cross-linked gellan gum and retrograded starch blend hydrogels for drug delivery applications. J Mech Behav Biomed Mater 65:317–333.  https://doi.org/10.1016/j.jmbbm.2016.08.005CrossRefGoogle Scholar
  94. Paderni C, Compilato D, Giannola LI, Campisi G (2012) Oral local drug delivery and new perspectives in oral drug formulation. Oral Surg Oral Med Oral Pathol Oral Radiol 114:e25–e34.  https://doi.org/10.1016/j.oooo.2012.02.016CrossRefPubMedGoogle Scholar
  95. Pietrzak-Nguyen A et al (2014) Enhanced in vivo targeting of murine nonparenchymal liver cells with monophosphoryl lipid A functionalized microcapsules. Biomacromolecules 15:2378–2388.  https://doi.org/10.1021/bm5006728CrossRefPubMedGoogle Scholar
  96. Rajan M, Raj V (2013) Potential drug delivery applications of chitosan based nanomaterials. Int Rev Chem Eng 5:145–155Google Scholar
  97. Reinhold AK, Rittner HL (2017) Barrier function in the peripheral and central nervous system—a review. Pflug Arch Eur J Phy 469:123–134.  https://doi.org/10.1007/s00424-016-1920-8CrossRefGoogle Scholar
  98. Richardson JL, Farraj NF, Illum L (1992) Enhanced vaginal absorption of insulin in sheep using lysophosphatidylcholine and a bioadhesive microsphere delivery system. Int J Pharm 88:319–325.  https://doi.org/10.1016/0378-5173(92)90330-5CrossRefGoogle Scholar
  99. Rodrigues A, Emeje M (2012) Recent applications of starch derivatives in nanodrug delivery. Carbohydr Polym 87:987–994.  https://doi.org/10.1016/j.carbpol.2011.09.044CrossRefGoogle Scholar
  100. Roohi F, Lohrke J, Ide A, Schütz G, Dassler K (2012) Studying the effect of particle size and coating type on the blood kinetics of superparamagnetic iron oxide nanoparticles. Int J Nanomed 7:4447–4458.  https://doi.org/10.2147/IJN.S33120CrossRefGoogle Scholar
  101. Ruge CA et al (2012) The interplay of lung surfactant proteins and lipids assimilates the macrophage clearance of nanoparticles. PLOS ONE 7:e40775.  https://doi.org/10.1371/journal.pone.0040775CrossRefPubMedPubMedCentralGoogle Scholar
  102. Saikia C, Hussain A, Ramteke A, Sharma HK, Maji TK (2014) Crosslinked thiolated starch coated Fe3O4 magnetic nanoparticles: effect of montmorillonite and crosslinking density on drug delivery properties. Starch - Stärke 66:760–771CrossRefGoogle Scholar
  103. Saikia C, Hussain A, Ramteke A, Sharma HK, Maji TK (2015) Carboxymethyl starch-chitosan-coated iron oxide magnetic nanoparticles for controlled delivery of isoniazid. J Microencapsul 32:29–39CrossRefGoogle Scholar
  104. Saikia C, Das MK, Ramteke A, Maji TK (2016) Effect of crosslinker on drug delivery properties of curcumin loaded starch coated iron oxide nanoparticles. Int J Biol Macromol 93:1121–1132.  https://doi.org/10.1016/j.ijbiomac.2016.09.043CrossRefGoogle Scholar
  105. Saikia C, Das MK, Ramteke A, Maji TK (2017) Evaluation of folic acid tagged aminated starch/ZnO coated iron oxide nanoparticles as targeted curcumin delivery system. Carbohydr Polym 157:391–399.  https://doi.org/10.1016/j.carbpol.2016.09.087CrossRefPubMedGoogle Scholar
  106. Satchi-Fainaro R, Duncan R, Barnes CM (2006) Polymer therapeutics for cancer: current status and future challenges. In: Satchi-Fainaro R, Duncan R (eds) Polymer therapeutics II, 1 edn. Springer, Berlin, pp 1–65.  https://doi.org/10.1007/12_024
  107. Shalviri A, Cai P, Rauth AM, Henderson JT, Wu XY (2012) Evaluation of new bi-functional terpolymeric nanoparticles for simultaneous in vivo optical imaging and chemotherapy of breast cancer. Drug Delivery Transl Res 2:437–453.  https://doi.org/10.1007/s13346-012-0103-1CrossRefGoogle Scholar
  108. Sieradzki R, Traitel T, Goldbart R, Geresh S, Kost J (2014) Tailoring quaternized starch as a non-viral carrier for gene delivery applications. Polym Adv Technol 25:552–561.  https://doi.org/10.1002/pat.3277CrossRefGoogle Scholar
  109. Situ W, Li X, Liu J, Chen L (2015) Preparation and characterization of glycoprotein-resistant starch complex as a coating material for oral bioadhesive microparticles for colon-targeted polypeptide delivery. J Agric Food Chem 63:4138–4147CrossRefGoogle Scholar
  110. Soane RJ, Frier M, Perkins AC, Jones NS, Davis SS, Illum L (1999) Evaluation of the clearance characteristics of bioadhesive systems in humans. Int J Pharm 178:55–65.  https://doi.org/10.1016/s0378-5173(98)00367-6CrossRefPubMedGoogle Scholar
  111. Stjarnkvist P, Laakso T, Sjoholm I (1989) Biodegradable microspheres XII: properties of the crosslinking chains in polyacryl starch microparticles. J Pharm Sci 78:52–56CrossRefGoogle Scholar
  112. Stjarnkvist P, Degling L, Sjoholm I (1991) Biodegradable microspheres. XIII: immune response to the DNP hapten conjugated to polyacryl starch microparticles. J Pharm Sci 80:436–440CrossRefGoogle Scholar
  113. Strindelius L, Folkesson A, Normark S, Sjoholm I (2004) Immunogenic properties of the Salmonella atypical fimbriae in BALB/c mice. Vaccine 22:1448–1456.  https://doi.org/10.1016/j.vaccine.2003.10.012CrossRefPubMedGoogle Scholar
  114. Sturesson C, Degling Wikingsson L (2000) Comparison of poly(acryl starch) and poly(lactide-co-glycolide) microspheres as drug delivery system for a rotavirus vaccine. J Controlled Release 68:441–450.  https://doi.org/10.1016/s0168-3659(00)00294-7CrossRefGoogle Scholar
  115. Surini S, Anggriani V, Anwar E (2009) Study of mucoadhesive microspheres based on pregelatinized cassava starch succinate as a new carrier for drug delivery. J Med Sci 9:249–256.  https://doi.org/10.3923/jms.2009.249.256CrossRefGoogle Scholar
  116. Thakore S, Valodkar M, Soni JY, Vyas K, Jadeja RN, Devkar RV, Rathore PS (2013) Synthesis and cytotoxicity evaluation of novel acylated starch nanoparticles. Bioorganic Chem 46:26–30.  https://doi.org/10.1016/j.bioorg.2012.10.001CrossRefGoogle Scholar
  117. Thiele C, Auerbach D, Jung G, Qiong L, Schneider M, Wenz G (2011) Nanoparticles of anionic starch and cationic cyclodextrin derivatives for the targeted delivery of drugs. Polym Chem 2:209–215.  https://doi.org/10.1039/c0py00241kCrossRefGoogle Scholar
  118. Vasir JK, Tambwekar K, Garg S (2003) Bioadhesive microspheres as a controlled drug delivery system. Int J Pharm 255:13–32.  https://doi.org/10.1016/S0378-5173(03)00087-5CrossRefPubMedGoogle Scholar
  119. Vyas SP, Jain CP (1992) Bioadhesive polymer-grafted starch microspheres bearing isosorbide dinitrate for buccal administration. J Microencapsul 9:457–464.  https://doi.org/10.3109/02652049209040484CrossRefPubMedGoogle Scholar
  120. Wang J, Liu H, Leng F, Zheng L, Yang J, Wang W, Huang CZ (2014) Autofluorescent and pH-responsive mesoporous silica for cancer-targeted and controlled drug release. Microporous Mesoporous Mater 186:187–193.  https://doi.org/10.1016/j.micromeso.2013.11.006CrossRefGoogle Scholar
  121. Winzen S, Schoettler S, Baier G, Rosenauer C, Mailaender V, Landfester K, Mohr K (2015) Complementary analysis of the hard and soft protein corona: sample preparation critically effects corona composition. Nanoscale 7:2992–3001.  https://doi.org/10.1039/c4nr05982dCrossRefPubMedGoogle Scholar
  122. Witschi C, Mrsny RJ (1999) In vitro evaluation of microparticles and polymer gels for use as nasal platforms for protein delivery. Pharm Res 16:382–390.  https://doi.org/10.1023/a:1018869601502CrossRefPubMedGoogle Scholar
  123. Xiao SY et al (2006) Preparation of folate-conjugated starch nanoparticles and its application to tumor-targeted drug delivery vector. Chin Sci Bull 51:1693–1697.  https://doi.org/10.1007/s11434-006-2039-7CrossRefGoogle Scholar
  124. Xiao H, Yang T, Lin Q, Liu GQ, Zhang L, Yu F, Chen Y (2016) Acetylated starch nanocrystals: preparation and antitumor drug delivery study. Int J Biol Macromol 89:456–464.  https://doi.org/10.1016/j.ijbiomac.2016.04.037CrossRefGoogle Scholar
  125. Yadav AV, Mote HH (2008) Development of Biodegradable Starch Microspheres for Intranasal Delivery. Indian J Pharm Sci 70:170–174.  https://doi.org/10.4103/0250-474X.41450CrossRefGoogle Scholar
  126. Yamada H, Loretz B, Lehr C-M (2014) Design of starch-graft-PEI polymers: an effective and biodegradable gene delivery platform. Biomacromolecules 15:1753–1761CrossRefGoogle Scholar
  127. Yang Y, Jiang JS, Du B, Gan ZF, Qian M, Zhang P (2009) Preparation and properties of a novel drug delivery system with both magnetic and biomolecular targeting. J Mater Sci Mater Med 20:301–307.  https://doi.org/10.1007/s10856-008-3577-0CrossRefPubMedGoogle Scholar
  128. Ye L et al (2016) Zwitterionic-modified starch-based stealth micelles for prolonging circulation time and reducing macrophage response. ACS Appl Mater Interfaces 8:4385–4398CrossRefGoogle Scholar
  129. Zhang AP et al (2013a) Disulfide crosslinked PEGylated starch micelles as efficient intracellular drug delivery platforms. Soft Matter 9:2224–2233.  https://doi.org/10.1039/c2sm27189cCrossRefGoogle Scholar
  130. Zhang J, Shin MC, David AE, Zhou J, Lee K, He H, Yang VC (2013b) Long-circulating heparin-functionalized magnetic nanoparticles for potential application as a protein drug delivery platform. Mol Pharm 10:3892–3902.  https://doi.org/10.1021/mp400360qCrossRefPubMedGoogle Scholar
  131. Zhang L et al (2013c) Zwitterionic hydrogels implanted in mice resist the foreign-body reaction. Nat Biotechnol 31:553–556CrossRefGoogle Scholar
  132. Zhang J, Shin MC, Yang VC (2014) Magnetic targeting of novel heparinized iron oxide nanoparticles evaluated in a 9L-glioma mouse model. Pharm Res 31:579–592.  https://doi.org/10.1007/s11095-013-1182-5CrossRefGoogle Scholar

Copyright information

© Springer Nature Singapore Pte Ltd. 2019

Authors and Affiliations

  1. 1.Guangdong Province Key Laboratory for Green Processing of Natural Products and Product Safety, School of Food Science and Engineering, Ministry of Education Engineering Research Center of Starch and Protein ProcessingSouth China University of TechnologyGuangzhouChina
  2. 2.International Institute for Nanocomposites Manufacturing (IINM), WMGUniversity of WarwickCoventryUK

Personalised recommendations