Starch-Based DDSs with Stimulus Responsiveness

  • Jin ChenEmail author
  • Ling Chen
  • Fengwei Xie
  • Xiaoxi Li


Owing to the excellent biodegradability and biocompatibility of starch, numerous efforts have been undertaken to prepare stimulus-responsive drug delivery systems (DDSs) from starch and its derivatives during the past few decades. The biological stimuli at the different organ and cellular compartment-specific levels or pathological conditions including pH, enzyme, temperature, and redox potential have been exploited for the development of starch-based stimulus-responsive DDSs. These types of stimulus responsiveness of starch-based DDSs can be achieved by incorporating functional groups to starch, such as disulfide bonds to acquire redox sensitiveness, or by changing physicochemical properties, such as hydrophilicity/hydrophobicity of starch derivatives to acquire temperature sensitiveness. Besides, magnetic-responsive starch-based DDSs have been developed by the incorporation of magnetic particles with starch film coatings or in starch matrix. The individual starch-based, stimulus-responsive DDSs have to some extent been reasonably well validated. Furthermore, two or more response elements have been combined to functionalize starch-based DDSs for smart drug release behavior. In this chapter, the role and application of starch and its derivatives in DDSs endowed with individual, dual, and multi-stimuli responsiveness will be discussed.


Starch-based drug delivery system Stimulus responsiveness pH responsiveness Enzymatic responsiveness Temperature responsiveness Redox responsiveness Magnetic responsiveness Dual and multi-responsiveness 


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Copyright information

© Springer Nature Singapore Pte Ltd. 2019

Authors and Affiliations

  1. 1.Guangdong Province Key Laboratory for Green Processing of Natural Products and Product Safety, School of Food Science and Engineering, Ministry of Education Engineering Research Center of Starch and Protein ProcessingSouth China University of TechnologyGuangzhouChina
  2. 2.International Institute for Nanocomposites Manufacturing (IINM), WMGUniversity of WarwickCoventryUK

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