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Peyer’s Patch: Targeted Drug Delivery for Therapeutics Benefits

  • Rakesh P. PatelEmail author
  • Pranav Shah
  • Kalyani Barve
  • Nikunjana Patel
  • Jaimini Gandhi
Chapter
  • 37 Downloads

Abstract

Specialized microfold cells (M cells) within the follicle-associated endothelium of intestinal Peyer’s patches play a key role in body’s defence mechanism by endocytosing macromolecules. Particulate uptake by the Peyer’s patch offers a very attractive avenue for delivering drugs through the peroral route. This review describes the pathway of drug delivery by Peyer’s patch targeting and its associated advantages. Disorders affecting the function of the lymphatic and immune system can be treated by targeting the active moieties at the Peyer’s patch. Drugs have been delivered to the Peyer’s patch for autoimmune disorders like HIV/AIDS, rheumatoid arthritis, chronic inflammatory disorders, tuberculosis, psoriasis and cancer. Several drug delivery systems like nanoparticles, dendrimers, microspheres, SMEDDS and liposomes have been reviewed for oral lymphatic delivery of small-sized drugs as well as macromolecular drugs like vaccines for immunogenic response. Factors such as surface charge, size, hydrophobicity, surface modification and conjugation have been found to be important determinants in modulating the targeting of these drugs to Peyer’s patches. These novel drug carriers are particularly useful in improving the oral bioavailability and efficacy of the drugs by selective utilization of lymphatic absorption avoiding the portal circulation. Further research in the direction of elucidating the mechanisms of drug transport to the intestinal lymphatic system specifically the cellular and intracellular events may help in delivering a greater number of drugs through the Peyer’s patch.

Keywords

Peyer’s patch Targeting Nanoparticles Dendrimers Microspheres Nano-/microemulsions SEDDS/SMEDDS Liposomes 

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Copyright information

© Springer Nature Singapore Pte Ltd. 2019

Authors and Affiliations

  • Rakesh P. Patel
    • 1
    Email author
  • Pranav Shah
    • 2
  • Kalyani Barve
    • 3
  • Nikunjana Patel
    • 4
  • Jaimini Gandhi
    • 2
  1. 1.Pharmaceutics & Pharmaceutical Technology Department, Shree S. K. Patel College of Pharmaceutical Education & ResearchGanpat UniversityMahesanaIndia
  2. 2.Department of Pharmaceutics, Maliba Pharmacy CollegeUkaTarsadia UniversityBardoliIndia
  3. 3.Department of PharmacologyShobhaben Pratapbhai Patel School of Pharmacy and Technology Management, SVKM’s NMIMSMumbaiIndia
  4. 4.Department of Pharmacognosy, Shree S. K. Patel College of Pharmaceutical Education & ResearchGanpat UniversityMehsanaIndia

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