Functions of Metabolism-Related Signaling Pathways in the Regulation of Toxicity of Environmental Toxicants or Stresses
We here selected the fat metabolism as an example to discuss the potential involvement of metabolism-related signaling pathways in the regulation of toxicity of environmental toxicants or stresses. We first introduced and discussed the functions of fat metabolic sensors (SBP-1, NHR-49, MDT-15, and NHR-80) and related signaling pathways in regulating the toxicity of environmental toxicants or stresses. Moreover, we discussed the roles of different components of the fat metabolic pathways during the regulation of toxicity of environmental toxicants or stresses. We also discussed the important function of fatty acid transport protein ACS-22 in regulating the toxicity of environmental toxicants or stresses. The described information in this chapter will help us to establish a connection between certain metabolism(s) and toxicity induction of environmental toxicants and stresses in nematodes.
KeywordsMetabolism-related signaling pathway Fatty acid metabolism Molecular regulation Environmental exposure Caenorhabditis elegans
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