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Antimicrobial Peptides of Multicellular Organisms: My Perspective

  • Michael ZasloffEmail author
Chapter
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 1117)

Abstract

Antimicrobial peptides of multicellular organisms were first characterized in the 1980s by investigators who felt that known systems of immunity could not explain what they observed: the resistance to bacterial infection of a Cecropia moth pupa lacking antibodies or lymphocytes (cecropins (Steiner 1981)), the potent microbicidal activity of neutrophils from a rabbit (defensins (Selsted et al. 1985)), and the healing of a wound on the skin of the African clawed frog without infection in a non-sterile aquarium (magainins (Zasloff 1987)). Since then AMPs have been discovered in diverse species of fungi, plants, and animals (Seshadri Sundararajan et al. 2012; Fan et al. 2016; Waghu et al. 2016; Wang et al. 2016). It is likely that we will discover that every multicellular organism expresses antimicrobial peptides as a key element of their immune system. Why are antimicrobial peptides so popular in Nature?

References

  1. Augustin R et al (2017) A secreted antibacterial neuropeptide shapes the microbiome of Hydra. Nat Commun 8(1):698CrossRefPubMedPubMedCentralGoogle Scholar
  2. Brogden KA (2005) Antimicrobial peptides: pore formers or metabolic inhibitors in bacteria? Nat Rev Microbiol 3(3):238–250CrossRefPubMedGoogle Scholar
  3. Brogden KA et al (2005) The nervous system and innate immunity: the neuropeptide connection. Nat Immunol 6(6):558–564CrossRefPubMedGoogle Scholar
  4. Fan L et al (2016) DRAMP: a comprehensive data repository of antimicrobial peptides. Sci Rep 6:24482CrossRefPubMedPubMedCentralGoogle Scholar
  5. Park CB et al (2000) Structure-activity analysis of buforin II, a histone H2A-derived antimicrobial peptide: the proline hinge is responsible for the cell-penetrating ability of buforin II. Proc Natl Acad Sci U S A 97(15):8245–8250CrossRefPubMedPubMedCentralGoogle Scholar
  6. Pezzulo AA et al (2012) Reduced airway surface pH impairs bacterial killing in the porcine cystic fibrosis lung. Nature 487(7405):109–113CrossRefPubMedPubMedCentralGoogle Scholar
  7. Schneider T et al (2010) Plectasin, a fungal defensin, targets the bacterial cell wall precursor Lipid II. Science 328(5982):1168–1172CrossRefPubMedGoogle Scholar
  8. Selsted ME et al (1985) Primary structures of six antimicrobial peptides of rabbit peritoneal neutrophils. J Biol Chem 260(8):4579–4584PubMedGoogle Scholar
  9. Seshadri Sundararajan V et al (2012) DAMPD: a manually curated antimicrobial peptide database. Nucleic Acids Res 40(Database issue):D1108–D1112CrossRefPubMedGoogle Scholar
  10. Steiner H et al (1981) Sequence and specificity of two antibacterial proteins involved in insect immunity. Nature 292(5820):246–248CrossRefGoogle Scholar
  11. Thevissen K et al (2004) Defensins from insects and plants interact with fungal glucosylceramides. J Biol Chem 279(6):3900–3905CrossRefPubMedGoogle Scholar
  12. Waghu FH et al (2016) CAMPR3: a database on sequences, structures and signatures of antimicrobial peptides. Nucleic Acids Res 44(D1):D1094–D1097CrossRefPubMedGoogle Scholar
  13. Wang G et al (2016) APD3: the antimicrobial peptide database as a tool for research and education. Nucleic Acids Res 44(D1):D1087–D1093CrossRefGoogle Scholar
  14. Wehkamp J et al (2005) Reduced Paneth cell alpha-defensins in ileal Crohn’s disease. Proc Natl Acad Sci U S A 102(50):18129–18134CrossRefPubMedPubMedCentralGoogle Scholar
  15. Zasloff M (1987) Magainins, a class of antimicrobial peptides from Xenopus skin: isolation, characterization of two active forms, and partial cDNA sequence of a precursor. Proc Natl Acad Sci U S A 84(15):5449–5453CrossRefPubMedPubMedCentralGoogle Scholar
  16. Zasloff M (2002) Antimicrobial peptides of multicellular organisms. Nature 415(6870):389–395CrossRefGoogle Scholar

Copyright information

© Springer Nature Singapore Pte Ltd. 2019

Authors and Affiliations

  1. 1.MedStar Georgetown Transplant InstituteGeorgetown University School of MedicineWashingtonUSA

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