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Lymph Formation and Transport: Role in Trauma-Hemorrhagic Shock

  • Zi-Gang Zhao
  • Yu-Ping Zhang
  • Li-Min Zhang
  • Ya-Xiong Guo
Chapter

Abstract

Microcirculatory disturbance is the key line of multiple organ dysfunction and failure following trauma-hemorrhagic shock (T/HS). The lymphatic circulation is an important component of the circulatory system, which is involved in the pathogenesis of T/HS. In the early stage of T/HS, the enhanced lymphatic constriction and reactivity, paralleling with the increased lymph formation and transport, play an important compensatory role in alleviating tissue edema and organ injury. Afterward, along with the continuation of hypotension, the lymphatic contractility and reactivity are reduced that causes tissue edema and organ injury. Moreover, T/HS-induced ischemia and/or reperfusion result in intestinal barrier injury and lymphatic endothelial barrier dysfunction. Because mesenteric lymph return is a vital contributor to intestinal bacteria-endotoxin translocation, these adverse effects further lead to uncontrolled inflammation, vascular hyperpermeability and hyporeactivity, immunosuppression, and subsequent multiple organ injury. Thus, increasing lymph formation and transport via regulation of lymphatic function may serve as a means of antagonizing the pathogenesis of T/HS.

Keywords

Trauma-hemorrhagic shock Lymphatic function Mesenteric lymph 

Notes

Acknowledgment

Research reported in this review from the authors’ laboratories was supported by grants from the National Natural Science Foundation of China (39070388, 30370561, 30770845, and 30971203) and the Natural Science Foundation of Hebei Province (C2004000649, C2008000503, C2010001433, and H2012405020). The authors appreciate Prof. Niu Chun-yu and Prof. Zhang Jing for the extraordinary contributions to our researches in shock and lymphatic microcirculation. Also, the authors thank Dr. Xue Bao-jian and Prof. Liu Liang-ming for reviewing the manuscript.

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Copyright information

© Springer Nature Singapore Pte Ltd. 2019

Authors and Affiliations

  • Zi-Gang Zhao
    • 1
  • Yu-Ping Zhang
    • 1
  • Li-Min Zhang
    • 1
  • Ya-Xiong Guo
    • 1
  1. 1.Institute of MicrocirculationHebei North UniversityZhangjiakouPeople’s Republic of China

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