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The Role of Mitochondrial Quality Imbalance in Multiple Organ Dysfunction Syndrome Following Severe Trauma, Shock, and Sepsis

  • Lei Kuang
  • Liangming Liu
  • Tao Li
Chapter

Abstract

Multiple organ dysfunction syndrome (MODS) is a life-threatening condition with high morbidity and mortality. Mitochondria are multifunctional organelles, whose failure triggers multiple organ dysfunction and is directly associated with patient’s vicious outcome. Physiologically, mitochondria undergo continuous fission, fusion, biogenesis, and mitophagy (selective mitochondrial autophagy) to maintain homeostasis, whose disruption may heavily impact the mitochondrial quality and result in damaged cell and organ functions under pathological conditions such as severe trauma, shock, and sepsis. Mitochondrial quality imbalance is a key step in MODS process, and rebalancing the mitochondrial quality may be a promising approach in the treatment of MODS following severe trauma, shock, and sepsis.

Keywords

MODS Mitochondrial quality Intensive care medicine Severe trauma Mitochondrial dynamics Mitophagy 

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Copyright information

© Springer Nature Singapore Pte Ltd. 2019

Authors and Affiliations

  • Lei Kuang
    • 1
  • Liangming Liu
    • 1
  • Tao Li
    • 1
  1. 1.State Key Laboratory of Trauma, Burns and Combined Injury, Daping Hospital and Research Institute of SurgeryThird Military Medical UniversityChongqingP. R. China

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