The Prospects of Cadherin-23 as a Mediator of Homophilic Cell-Cell Adhesion

  • Malay Kumar Sannigrahi
  • Sai Srinivas
  • Sabyasachi RakshitEmail author
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 1112)


Cadherins (calcium-dependent adhesion proteins) constitute a family of cell surface proteins that mediate cell-cell adhesion and actively participate in tissue morphogenesis and in mediating tissue integrity. The ecto-domains of cadherins from opposing cell surfaces interact with each other to form the load-bearing trans-dimers and mechanically hold cells together. The “classical” cadherins and desmosomes that form separate groups in cadherin superfamily are mostly explored for their roles in cell-cell adhesion. However, majority of cadherins in cells belong to “nonclassical” group which is poorly explored in the context of their cell-binding properties. This review focuses on the role of “nonclassical” cadherin, cadherin-23, in cell-cell adhesion. Overall, this review highlights the need for further investigations on the role of “nonclassical” cadherin-23 in cell-cell adhesion.


Nonclassical cadherins Cadherin-23 Cell-cell adhesion Cancer 


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© Springer Nature Singapore Pte Ltd. 2018

Authors and Affiliations

  • Malay Kumar Sannigrahi
    • 1
  • Sai Srinivas
    • 1
  • Sabyasachi Rakshit
    • 1
    • 2
    Email author
  1. 1.Department of Chemical SciencesIndian Institute of Science Education and Research (IISER) MohaliMohaliIndia
  2. 2.Centre for Protein Science Design and EngineeringIndian Institute of Science Education and Research (IISER) MohaliMohaliIndia

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