Soluble Amyloid Precursor Protein α: Friend or Foe?

  • Nicola J. Corbett
  • Nigel M. HooperEmail author
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 1112)


The “amyloidogenic” proteolytic processing of the cell surface amyloid precursor protein (APP) produces amyloid-β, which causes a range of detrimental effects in the neuron, such as synaptic loss, and plays a key role in Alzheimer’s disease. In contrast, “non-amyloidogenic” proteolytic processing, which involves the cleavage of APP by α-secretase, produces soluble amyloid precursor protein α (sAPPα) and is the most predominant proteolytic processing of APP in the healthy brain. Current research suggests that sAPPα plays a role in synaptic growth and plasticity, but whether this role is protective or detrimental is age-dependent. This review looks at the effects of increasing sAPPα during three time-points in life (in development, young adult, ageing/neurodegeneration) when synaptic plasticity plays an important role.


Soluble amyloid precursor protein α (sAPPα) Amyloid precursor protein (APP) A disintegrin and metalloproteinase domain-containing protein 10 (ADAM10) Synaptic plasticity Development Ageing Neurodegeneration Neuroprotection Dendritic spines 


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© Springer Nature Singapore Pte Ltd. 2018

Authors and Affiliations

  1. 1.Division of Neuroscience & Experimental Psychology, School of Biological Sciences, Faculty of Biology, Medicine and HealthUniversity of ManchesterManchesterUK

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