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Vulvar Glandular and Other Neoplasms

  • Andrew Dunn
  • Michael DeWall
  • Jennifer KaleyEmail author
Chapter

Abstract

This chapter will address vulvar neoplasms with glandular differentiation as well as neuroendocrine carcinoma and metastatic tumors. These entities are rare, as the vast majority of malignancies of the vulva are squamous in origin. Careful consideration of the differential diagnosis, as well as knowledge of any pertinent clinical history, is essential when evaluating these lesions.

Keywords

Adenosquamous carcinoma Adenocarcinoma Bartholin Merkel Cloacogenic Metastasis 

References

  1. 1.
    Underwood JW, Adcock LL, Okagaki T. Adenosquamous carcinoma of skin appendages (adenoid squamous cell carcinoma, pseudoglandular squamous cell carcinoma, adenoacanthoma of sweat gland of lever) of the vulva: a clinical and ultrastructural study. Cancer. 1978;42(4):1851.PubMedCrossRefPubMedCentralGoogle Scholar
  2. 2.
    Crum CP, Haefner HK, Peters WA. Diagnostic gynecologic and obstetric pathology. 3rd ed. Philadelphia, PA: Elsevier, Inc.; 2018.Google Scholar
  3. 3.
    Carson LF, Twiggs LB, Okagaki T, Clark BA, Ostrow RS, Faras AJ. Human papillomavirus DNA in adenosquamous carcinoma and squamous cell carcinoma of the vulva. Obstet Gynecol. 1988;72(1):63.PubMedPubMedCentralGoogle Scholar
  4. 4.
    Johnson WC, Helwig EB. Adenoid squamous cell carcinoma (adenoacanthoma). A clinicopathologic study of 155 patients. Cancer. 1966;19(11):1639.PubMedCrossRefPubMedCentralGoogle Scholar
  5. 5.
    Rhatigan RM, Mojadidi Q. Adenosquamous carcinomas of the vulva and vagina. Am J Clin Pathol. 1973;60(2):208.PubMedCrossRefPubMedCentralGoogle Scholar
  6. 6.
    Bannatyne P, Elliott P, Russell P. Vulvar adenosquamous carcinoma arising in a hidradenoma papilliferum, with rapidly fatal outcome: case report. Gynecol Oncol. 1989;35(3):395.PubMedCrossRefPubMedCentralGoogle Scholar
  7. 7.
    Lasser A, Cornog JL, Morris JM. Adenoid squamous cell carcinoma of the vulva. Cancer. 1974;33(1):224.PubMedCrossRefPubMedCentralGoogle Scholar
  8. 8.
    Curtin JP, Rubin SC, Jones WB, Hoskins WJ, Lewis JL Jr. Paget’s disease of the vulva. Gynecol Oncol. 1990;39(3):374.PubMedCrossRefPubMedCentralGoogle Scholar
  9. 9.
    Jones IS, Crandon A, Sanday K. Paget’s disease of the vulva: diagnosis and follow-up key to management; a retrospective study of 50 cases from Queensland. Gynecol Oncol. 2011;122(1):42.PubMedCrossRefPubMedCentralGoogle Scholar
  10. 10.
    Asaka S, Yoshizawa A, Sano K, Uhara H, Honda T, Ota H. A case of vulval extramammary paget disease with dermal invasion showing mucinous carcinoma. Int J Gynecol Pathol. 2015;34(4):396.PubMedCrossRefPubMedCentralGoogle Scholar
  11. 11.
    Shaco-Levy R, Bean SM, Vollmer RT, et al. Paget disease of the vulva: a histologic study of 56 cases correlating pathologic features and disease course. Int J Gynecol Pathol. 2010;29(1):69.PubMedCrossRefPubMedCentralGoogle Scholar
  12. 12.
    Tebes S, Cardosi R, Hoffman M. Paget’s disease of the vulva. Am J Obstet Gynecol. 2002;187(2):281.PubMedCrossRefPubMedCentralGoogle Scholar
  13. 13.
    Zhang C, Zhang P, Sung CJ, Lawrence WD. Overexpression of p53 is correlated with stromal invasion in extramammary Paget’s disease of the vulva. Hum Pathol. 2003;34(9):880.PubMedCrossRefPubMedCentralGoogle Scholar
  14. 14.
    Shiomi T, Yoshida Y, Shomori K, Yamamoto O, Ito H. Extramammary Paget’s disease: evaluation of the histopathological patterns of Paget cell proliferation in the epidermis. J Dermatol. 2011;38(11):1054.PubMedCrossRefPubMedCentralGoogle Scholar
  15. 15.
    Goldblum JR, Hart WR. Perianal Paget's disease: a histologic and immunohistochemical study of 11 cases with and without associated rectal adenocarcinoma. Am J Surg Pathol. 1998;22(2):170.PubMedCrossRefPubMedCentralGoogle Scholar
  16. 16.
    Brainard JA, Hart WR. Proliferative epidermal lesions associated with anogenital Paget’s disease. Am J Surg Pathol. 2000;24(4):543.PubMedCrossRefPubMedCentralGoogle Scholar
  17. 17.
    Brown HM, Wilkinson EJ. Uroplakin-III to distinguish primary vulvar Paget disease from Paget disease secondary to urothelial carcinoma. Hum Pathol. 2002;33(5):545.PubMedCrossRefPubMedCentralGoogle Scholar
  18. 18.
    Zhao M, Zhou L, Sun L, et al. GATA3 is a sensitive marker for primary genital extramammary Paget disease: an immunohistochemical study of 72 cases with comparison to gross cystic disease fluid protein 15. Diagn Pathol. 2017;12(1):51.PubMedCrossRefPubMedCentralGoogle Scholar
  19. 19.
    Morbeck D, Tregnago AC, Netto GB, et al. GATA3 expression in primary vulvar Paget disease: a potential pitfall leading to misdiagnosis of pagetoid urothelial intraepithelial neoplasia. Histopathology. 2017;70(3):435.PubMedCrossRefPubMedCentralGoogle Scholar
  20. 20.
    Goncalves Amorim A, Batista Fraga Mendes B, Neves Ferreira R, Chambo Filho A. Paget disease of the vulva: diagnosis by immunohistochemistry. Case Rep Dermatol Med. 2015;2015:162483.PubMedPubMedCentralGoogle Scholar
  21. 21.
    Diaz de Leon E, Carcangiu ML, Prieto VG, et al. Extramammary Paget disease is characterized by the consistent lack of estrogen and progesterone receptors but frequently expresses androgen receptor. Am J Clin Pathol. 2000;113(4):572.PubMedCrossRefPubMedCentralGoogle Scholar
  22. 22.
    Fox H, Wells M. Recent advances in the pathology of the vulva. Histopathology. 2003;42(3):209.PubMedCrossRefPubMedCentralGoogle Scholar
  23. 23.
    Ostler DA, Prieto VG, Reed JA, Deavers MT, Lazar AJ, Ivan D. Adipophilin expression in sebaceous tumors and other cutaneous lesions with clear cell histology: an immunohistochemical study of 117 cases. Mod Pathol. 2010;23(4):567.PubMedCrossRefPubMedCentralGoogle Scholar
  24. 24.
    Clark LN, Elwood HR, Uhlenhake EE, Smoller BR, Shalin SC, Gardner JM. Nuclear factor XIIIa staining (clone AC-1A1 mouse monoclonal) is a highly sensitive marker of sebaceous differentiation in normal and neoplastic sebocytes. J Cutan Pathol. 2016;43(8):657.PubMedCrossRefPubMedCentralGoogle Scholar
  25. 25.
    Dordevic M, Jovanovic B, Mitrovic S, Dordevic G. Ectopic mammary tissue in vulva. Vojnosanit Pregl. 2008;65(5):407.PubMedCrossRefPubMedCentralGoogle Scholar
  26. 26.
    Ishigaki T, Toriumi Y, Nosaka R, et al. Primary ectopic breast cancer of the vulva, treated with local excision of the vulva and sentinel lymph node biopsy: a case report. Surg Case Rep. 2017;3(1):69.PubMedCrossRefPubMedCentralGoogle Scholar
  27. 27.
    Pieh-Holder KL. Lactational ectopic breast tissue of the vulva: case report and brief historical review. Breastfeed Med. 2013;8:223.PubMedCrossRefPubMedCentralGoogle Scholar
  28. 28.
    Intra M, Maggioni A, Sonzogni A, et al. A rare association of synchronous intraductal carcinoma of the breast and invasive carcinoma of ectopic breast tissue of the vulva: case report and literature review. Int J Gynecol Cancer. 2006;16(Suppl 1):428.PubMedCrossRefPubMedCentralGoogle Scholar
  29. 29.
    Cripe J, Eskander R, Tewari K. Sentinel lymph node mapping of a breast cancer of the vulva: case report and literature review. World J Clin Oncol. 2015;6(2):16.PubMedCrossRefPubMedCentralGoogle Scholar
  30. 30.
    Lee S, Nodit L. Phyllodes tumor of vulva: a brief diagnostic review. Arch Pathol Lab Med. 2014;138(11):1546.PubMedCrossRefPubMedCentralGoogle Scholar
  31. 31.
    Heffernan TP, Sarode VR, Hoffman B, Lea J. Recurrent phyllodes tumor of the vulva: a case report with review of diagnostic criteria and differential diagnosis. Int J Gynecol Pathol. 2010;29(3):294.PubMedCrossRefPubMedCentralGoogle Scholar
  32. 32.
    Muto M, Inamura K, Ozawa N, et al. Skene’s gland adenocarcinoma with intestinal differentiation: a case report and literature review. Pathol Int. 2017;67(11):575.PubMedCrossRefPubMedCentralGoogle Scholar
  33. 33.
    Tsutsumi S, Kawahara T, Hattori Y, et al. Skene duct adenocarcinoma in a patient with an elevated serum prostate-specific antigen level: a case report. J Med Case Rep. 2018;12(1):32.PubMedCrossRefPubMedCentralGoogle Scholar
  34. 34.
    Baker GM, Selim MA, Hoang MP. Vulvar adnexal lesions: a 32-year, single-institution review from Massachusetts General Hospital. Arch Pathol Lab Med. 2013;137(9):1237.PubMedCrossRefPubMedCentralGoogle Scholar
  35. 35.
    Buhl A, Landow S, Lee YC, Holcomb K, Heilman E, Abulafia O. Microcystic adnexal carcinoma of the vulva. Gynecol Oncol. 2001;82(3):571.PubMedCrossRefPubMedCentralGoogle Scholar
  36. 36.
    Jacobs DM, Sandles LG, Leboit PE. Sebaceous carcinoma arising from Bowen’s disease of the vulva. Arch Dermatol. 1986;122(10):1191.PubMedCrossRefPubMedCentralGoogle Scholar
  37. 37.
    Sullivan SA, Tran AQ, O'Connor S, Gehrig PA. Sebaceous carcinoma of the vulva: a case report and review of the literature. Gynecol Oncol Rep. 2016;18:40.PubMedCrossRefPubMedCentralGoogle Scholar
  38. 38.
    Rutten A, Kutzner H, Mentzel T, et al. Primary cutaneous cribriform apocrine carcinoma: a clinicopathologic and immunohistochemical study of 26 cases of an under-recognized cutaneous adnexal neoplasm. J Am Acad Dermatol. 2009;61(4):644.PubMedCrossRefPubMedCentralGoogle Scholar
  39. 39.
    Kyllo RL, Brady KL, Hurst EA. Sebaceous carcinoma: review of the literature. Dermatol Surg. 2015;41(1):1.PubMedCrossRefPubMedCentralGoogle Scholar
  40. 40.
    Izumi M, Mukai K, Nagai T, et al. Sebaceous carcinoma of the eyelids: thirty cases from Japan. Pathol Int. 2008;58(8):483.PubMedCrossRefPubMedCentralGoogle Scholar
  41. 41.
    Evangelista MT, North JP. Comparative analysis of cytokeratin 15, TDAG51, cytokeratin 20 and androgen receptor in sclerosing adnexal neoplasms and variants of basal cell carcinoma. J Cutan Pathol. 2015;42(11):824.PubMedCrossRefPubMedCentralGoogle Scholar
  42. 42.
    Robson A, Lazar AJ, Ben Nagi J, et al. Primary cutaneous apocrine carcinoma: a clinico-pathologic analysis of 24 cases. Am J Surg Pathol. 2008;32(5):682.PubMedCrossRefPubMedCentralGoogle Scholar
  43. 43.
    Aslam A. Microcystic adnexal carcinoma and a summary of other rare malignant adnexal tumours. Curr Treat Options in Oncol. 2017;18(8):49.CrossRefGoogle Scholar
  44. 44.
    Sellheyer K, Nelson P, Kutzner H, Patel RM. The immunohistochemical differential diagnosis of microcystic adnexal carcinoma, desmoplastic trichoepithelioma and morpheaform basal cell carcinoma using BerEP4 and stem cell markers. J Cutan Pathol. 2013;40(4):363.PubMedCrossRefPubMedCentralGoogle Scholar
  45. 45.
    Ferringer T. Immunohistochemistry in dermatopathology. Arch Pathol Lab Med. 2015;139(1):83.PubMedCrossRefPubMedCentralGoogle Scholar
  46. 46.
    Jones MA, Mann EW, Caldwell CL, Tarraza HM, Dickersin GR, Young RH. Small cell neuroendocrine carcinoma of Bartholin’s gland. Am J Clin Pathol. 1990;94(4):439.PubMedCrossRefPubMedCentralGoogle Scholar
  47. 47.
    Felix JC, Cote RJ, Kramer EE, Saigo P, Goldman GH. Carcinomas of Bartholin’s gland. Histogenesis and the etiological role of human papillomavirus. Am J Pathol. 1993;142(3):925.PubMedPubMedCentralGoogle Scholar
  48. 48.
    Finan MA, Barre G. Bartholin's gland carcinoma, malignant melanoma and other rare tumours of the vulva. Best Pract Res Clin Obstet Gynaecol. 2003;17(4):609.PubMedCrossRefPubMedCentralGoogle Scholar
  49. 49.
    Bhalwal AB, Nick AM, Dos Reis R, et al. Carcinoma of the Bartholin gland: a review of 33 cases. Int J Gynecol Cancer. 2016;26(4):785.PubMedCrossRefPubMedCentralGoogle Scholar
  50. 50.
    Heller DS. Benign tumors and tumor-like lesions of the vulva. Clin Obstet Gynecol. 2015;58(3):526.PubMedCrossRefPubMedCentralGoogle Scholar
  51. 51.
    Yoon G, Kim HS, Lee YY, et al. Analysis of clinical outcomes of patients with adenoid cystic carcinoma of Bartholin glands. Int J Clin Exp Pathol. 2015;8(5):5688.PubMedPubMedCentralGoogle Scholar
  52. 52.
    Di Donato V, Casorelli A, Bardhi E, et al. Bartholin gland cancer. Crit Rev Oncol Hematol. 2017;117:1.PubMedCrossRefPubMedCentralGoogle Scholar
  53. 53.
    Penner CR, Folpe AL, Budnick SD. C-kit expression distinguishes salivary gland adenoid cystic carcinoma from polymorphous low-grade adenocarcinoma. Mod Pathol. 2002;15(7):687.PubMedCrossRefPubMedCentralGoogle Scholar
  54. 54.
    Rabban JT, Swain RS, Zaloudek CJ, Chase DR, Chen YY. Immunophenotypic overlap between adenoid cystic carcinoma and collagenous spherulosis of the breast: potential diagnostic pitfalls using myoepithelial markers. Mod Pathol. 2006;19(10):1351.PubMedCrossRefPubMedCentralGoogle Scholar
  55. 55.
    Kaufmann O, Dietel M. Expression of thyroid transcription factor-1 in pulmonary and extrapulmonary small cell carcinomas and other neuroendocrine carcinomas of various primary sites. Histopathology. 2000;36(5):415.PubMedCrossRefPubMedCentralGoogle Scholar
  56. 56.
    Dancey AL, Rayatt SS, Soon C, Ilchshyn A, Brown I, Srivastava S. Merkel cell carcinoma: a report of 34 cases and literature review. J Plast Reconstr Aesthet Surg. 2006;59(12):1294.PubMedCrossRefPubMedCentralGoogle Scholar
  57. 57.
    Gil-Moreno A, Garcia-Jimenez A, Gonzalez-Bosquet J, et al. Merkel cell carcinoma of the vulva. Gynecol Oncol. 1997;64(3):526.PubMedCrossRefPubMedCentralGoogle Scholar
  58. 58.
    Nguyen AH, Tahseen AI, Vaudreuil AM, Caponetti GC, Huerter CJ. Clinical features and treatment of vulvar Merkel cell carcinoma: a systematic review. Gynecol Oncol Res Pract. 2017;4:2.PubMedCrossRefPubMedCentralGoogle Scholar
  59. 59.
    Khoury-Collado F, Elliott KS, Lee YC, Chen PC, Abulafia O. Merkel cell carcinoma of the Bartholin’s gland. Gynecol Oncol. 2005;97(3):928.PubMedCrossRefPubMedCentralGoogle Scholar
  60. 60.
    Ball NJ, Tanhuanco-Kho G. Merkel cell carcinoma frequently shows histologic features of basal cell carcinoma: a study of 30 cases. J Cutan Pathol. 2007;34(8):612.PubMedCrossRefPubMedCentralGoogle Scholar
  61. 61.
    Iavazzo C, Terzi M, Arapantoni-Dadioti P, Dertimas V, Vorgias G. Vulvar merkel carcinoma: a case report. Case Rep Med. 2011;2011:546972.PubMedCrossRefPubMedCentralGoogle Scholar
  62. 62.
    Winer IS, Lonardo F, Johnson SC, Deppe G. Merkel cell carcinoma in a patient with noninvasive vulvar Paget’s disease. Am J Obstet Gynecol. 2012;207(1):e9.PubMedCrossRefPubMedCentralGoogle Scholar
  63. 63.
    Jensen K, Kohler S, Rouse RV. Cytokeratin staining in Merkel cell carcinoma: an immunohistochemical study of cytokeratins 5/6, 7, 17, and 20. Appl Immunohistochem Mol Morphol. 2000;8(4):310.PubMedPubMedCentralGoogle Scholar
  64. 64.
    Calder KB, Coplowitz S, Schlauder S, Morgan MB. A case series and immunophenotypic analysis of CK20-/CK7+ primary neuroendocrine carcinoma of the skin. J Cutan Pathol. 2007;34(12):918.PubMedCrossRefPubMedCentralGoogle Scholar
  65. 65.
    Miller DL, Weinstock MA. Nonmelanoma skin cancer in the United States: incidence. J Am Acad Dermatol. 1994;30(5 Pt 1):774.PubMedCrossRefPubMedCentralGoogle Scholar
  66. 66.
    Gilchrest BA, Eller MS, Geller AC, Yaar M. The pathogenesis of melanoma induced by ultraviolet radiation. N Engl J Med. 1999;340(17):1341.PubMedCrossRefPubMedCentralGoogle Scholar
  67. 67.
    de Giorgi V, Salvini C, Massi D, Raspollini MR, Carli P. Vulvar basal cell carcinoma: retrospective study and review of literature. Gynecol Oncol. 2005;97(1):192.PubMedCrossRefPubMedCentralGoogle Scholar
  68. 68.
    Kosari F, Daneshbod Y, Parwaresch R, Krams M, Wacker HH. Lymphomas of the female genital tract: a study of 186 cases and review of the literature. Am J Surg Pathol. 2005;29(11):1512.PubMedCrossRefPubMedCentralGoogle Scholar
  69. 69.
    Crowder S, Tuller E. Small cell carcinoma of the female genital tract. Semin Oncol. 2007;34(1):57.PubMedCrossRefPubMedCentralGoogle Scholar
  70. 70.
    Agoff SN, Lamps LW, Philip AT, et al. Thyroid transcription factor-1 is expressed in extrapulmonary small cell carcinomas but not in other extrapulmonary neuroendocrine tumors. Mod Pathol. 2000;13(3):238.PubMedCrossRefPubMedCentralGoogle Scholar
  71. 71.
    Liu SH, Ho CM, Huang SH, Shih BY, Lee FK. Cloacogenic adenocarcinoma of the vulva presenting as recurrent Bartholin’s gland infection. J Formos Med Assoc. 2003;102(1):49.PubMedPubMedCentralGoogle Scholar
  72. 72.
    Chibbar R, Wood KA, Giede CK, Agrawal A. Unusually aggressive primary cloacogenic carcinoma of the vulva: a case report and literature review. Case Rep Clinical Med. 2013;02(05):4.Google Scholar
  73. 73.
    Zaidi SN, Conner MG. Primary vulvar adenocarcinoma of cloacogenic origin. South Med J. 2001;94(7):744.PubMedCrossRefPubMedCentralGoogle Scholar
  74. 74.
    Tiltman AJ, Knutzen VK. Primary adenocarcinoma of the vulva originating in misplaced cloacal tissue. Obstet Gynecol. 1978;51(1 Suppl):30s.PubMedPubMedCentralGoogle Scholar
  75. 75.
    Ghamande SA, Kasznica J, Griffiths CT, Finkler NJ, Hamid AM. Mucinous adenocarcinomas of the vulva. Gynecol Oncol. 1995;57(1):117.PubMedCrossRefPubMedCentralGoogle Scholar
  76. 76.
    Kennedy JC, Majmudar B. Primary adenocarcinoma of the vulva, possibly cloacogenic. A report of two cases. J Reprod Med. 1993;38(2):113.PubMedPubMedCentralGoogle Scholar
  77. 77.
    Willen R, Bekassy CB, Bozoky B, Cajander S. Cloacogenic adenocarcinoma of the vulva. Gynecol Oncol. 1999;74(2):298.PubMedCrossRefPubMedCentralGoogle Scholar
  78. 78.
    Lee KC, Su WP, Muller SA. Multicentric cloacogenic carcinoma: report of a case with anogenital pruritus at presentation. J Am Acad Dermatol. 1990;23(5 Pt 2):1005.PubMedCrossRefPubMedCentralGoogle Scholar
  79. 79.
    Dube V, Veilleux C, Plante M, Tetu B. Primary villoglandular adenocarcinoma of cloacogenic origin of the vulva. Hum Pathol. 2004;35(3):377.PubMedCrossRefPubMedCentralGoogle Scholar
  80. 80.
    Crum CP, Nucci MR, Lee KR. Diagnostic gynecologic and obstetric pathology. 2nd ed. Philadelphia, PA: Saunders/Elsevier; 2011.Google Scholar
  81. 81.
    Lee IH, Kim MK, Lee YK, Hong SR, Lee KH. Primary mucinous adenocarcinoma of the vulva, intestinal type. Obstet Gynecol Sci. 2017;60(4):369.PubMedCrossRefPubMedCentralGoogle Scholar
  82. 82.
    Neto AG, Deavers MT, Silva EG, Malpica A. Metastatic tumors of the vulva: a clinicopathologic study of 66 cases. Am J Surg Pathol. 2003;27(6):799.PubMedCrossRefPubMedCentralGoogle Scholar
  83. 83.
    Matsuo K, Hew KE, Im DD, Rosenshein NB. Clitoral metastasis of anal adenocarcinoma associated with rectovaginal fistula in long standing Crohn’s disease. Eur J Obstet Gynecol Reprod Biol. 2009;144(2):182.PubMedCrossRefPubMedCentralGoogle Scholar
  84. 84.
    Sheen-Chen SM, Eng HL, Huang CC. Breast cancer metastatic to the vulva. Gynecol Oncol. 2004;94(3):858.PubMedCrossRefPubMedCentralGoogle Scholar
  85. 85.
    Rocconi RP, Leath CA 3rd, Johnson WM 3rd, Barnes MN 3rd, Conner MG. Primary lung large cell carcinoma metastatic to the vulva: a case report and review of the literature. Gynecol Oncol. 2004;94(3):829.PubMedCrossRefPubMedCentralGoogle Scholar
  86. 86.
    Curtin WM, Murthy B. Vulvar metastasis of breast carcinoma. A case report. J Reprod Med. 1997;42(1):61.PubMedPubMedCentralGoogle Scholar
  87. 87.
    Alligood-Percoco NR, Kessler MS, Willis G. Breast cancer metastasis to the vulva 20 years remote from initial diagnosis: a case report and literature review. Gynecol Oncol Rep. 2015;13:33.PubMedCrossRefPubMedCentralGoogle Scholar
  88. 88.
    Heidarpour M, Tavanafar Z. Diagnostic utility of PAX8 in differentiation of mullerian from non-mullerian tumors. Adv Biomed Res. 2014;3:96.PubMedCrossRefPubMedCentralGoogle Scholar
  89. 89.
    Wilkinson EJ, Brown HM. Vulvar Paget disease of urothelial origin: a report of three cases and a proposed classification of vulvar Paget disease. Hum Pathol. 2002;33(5):549.PubMedCrossRefPubMedCentralGoogle Scholar
  90. 90.
    Miliaras D. Breast-like cancer of the vulva: primary or metastatic? A case report and review of the literature. Eur J Gynaecol Oncol. 2002;23(4):350.PubMedPubMedCentralGoogle Scholar
  91. 91.
    Porzio G, Ficorella C, Calvisi G, Paris I, Ricevuto E, Marchetti P. Ductal breast carcinoma metastatic to the vulva: a case report. Eur J Gynaecol Oncol. 2001;22(2):147.PubMedPubMedCentralGoogle Scholar
  92. 92.
    Julien V, Labadie M, Gauthier G, Ronger-Savle S. Clitoral metastasis from ductal breast cancer revealing metastases in multiple sites and review of the literature. J Low Genit Tract Dis. 2012;16(1):66.PubMedCrossRefPubMedCentralGoogle Scholar
  93. 93.
    Menzin AW, De Risi D, Smilari TF, Kalish PE, Vinciguerra V. Lobular breast carcinoma metastatic to the vulva: a case report and literature review. Gynecol Oncol. 1998;69(1):84.PubMedCrossRefPubMedCentralGoogle Scholar
  94. 94.
    Papaioannou N, Zervoudis S, Grammatikakis I, Peitsidis P, Palvakis K, Youssef TF. Metastatic lobular carcinoma of the breast to the vulva: a case report and review of the literature. J Egypt Natl Canc Inst. 2010;22(1):57.PubMedPubMedCentralGoogle Scholar
  95. 95.
    Perrone G, Altomare V, Zagami M, et al. Breast-like vulvar lesion with concurrent breast cancer: a case report and critical literature review. In Vivo. 2009;23(4):629.PubMedPubMedCentralGoogle Scholar
  96. 96.
    Sindico R, Mariani L, Atlante M, Vincenzoni C, Tulini R, Benevolo M. Vulvar metastasis from breast carcinoma: a case report and review of the literature. Eur J Gynaecol Oncol. 1998;19(4):386.PubMedPubMedCentralGoogle Scholar
  97. 97.
    Valenzano Menada M, Papadia A, Lorenzi P, Fulcheri E, Ragni N. Breast cancer metastatic to the vulva after local recurrence occurring on a rectus abdominis myocutaneous flap: a case report and review of the literature. Eur J Gynaecol Oncol. 2003;24(6):577.PubMedPubMedCentralGoogle Scholar

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© Science Press & Springer Nature Singapore Pte Ltd.  2019

Authors and Affiliations

  1. 1.Department of PathologyUniversity of Arkansas for Medical SciencesLittle RockUSA

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