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Diagnostic Value of Fractional Exhaled Nitric Oxide (FeNO)

  • Kazuto MatsunagaEmail author
Chapter
Part of the Respiratory Disease Series: Diagnostic Tools and Disease Managements book series (RDSDTDM)

Abstract

Asthma is a heterogeneous disease, usually characterized by chronic inflammation of the airways. Fractional nitric oxide (NO) concentration in exhaled air (FeNO) is recognized as a noninvasive biomarker of eosinophilic inflammation in the lower respiratory tract. Presence of airway inflammation in addition to respiratory symptoms that are suggestive of asthma supports a diagnosis of asthma. This chapter provides recent topics pertaining to asthma including the mechanism of production of NO in the airway, methods of and interpretations in measuring FeNO, and the role of exhaled NO measurement in making diagnosis of asthma and differentiating asthma from chronic obstructive pulmonary disease (COPD).

Keywords

Asthma Airway inflammation COPD Exhaled nitric oxide Type 2 

Abbreviations

ACO

Asthma-COPD overlap

COPD

Chronic obstructive pulmonary disease

eNOS

Endothelial nitric oxide synthase

FeNO

Fractional nitric oxide concentration in exhaled air

FEV1

Forced expiratory volume in one second

FVC

Forced vital capacity

iNOS

Inducible nitric oxide synthase

NO

Nitric oxide

nNOS

Neuronal nitric oxide synthase

ROS

Reactive oxygen species

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Copyright information

© Springer Nature Singapore Pte Ltd. 2019

Authors and Affiliations

  1. 1.Department of Respiratory Medicine and Infectious DiseaseGraduate School of Medicine, Yamaguchi UniversityUbeJapan

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