Corticosteroid Resistance in Asthma
Although inhaled corticosteroid (ICS) is the typical medication for the treatment of asthma worldwide, there are patients who are nonresponsive to the treatment. Patients with GC-resistant asthma show more frequent exacerbation than other asthmatics, and the number of clinical consultations is much higher. It has been recognized in recent years that asthma is not a single disease; it is a syndrome with various phenotypes. The heterogeneity complicates the analysis of the pathology associated with GC resistance. However, the characterization of the inflammatory and immunological phenotypes and the classification into several end types will be crucial for elucidating the mechanism of GC-resistant asthma. Future work on the molecular mechanisms of GC resistance will facilitate the selection of therapeutic drugs according to the pathology of individual patients with refractory asthma resistant to GC treatment.
KeywordsAsthma Steroid resistant Type 2 innate lymphoid cell Th17 cell
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