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Safety and Genetic Stability of Cultured Perinatal Mesenchymal Stem Cells

  • Youwei Wang
Chapter

Abstract

Perinatal mesenchymal stem cells are considered as a promising tool to treat many diseases in clinical studies. Being different with chemical or protein drugs, perinatal stem cells were used as living cells. No method is well established to evaluate the safety issues of perinatal mesenchymal stem cells. This is a challenge not only for patients and physicians but also for manufacturers and administrators. Safety issues of perinatal stem cells could come from perinatal stem cells themselves, which include, but not limited to, cytokine storm, unwanted differentiation, and tumorigenesis. Other safety concerns of perinatal stem cells are related to processing and quality control when processing or manufacturing mesenchymal stem cells. After in vitro expansion, which is inevitable for clinical application, perinatal mesenchymal stem cells may change their biological characteristics. So it is critical to answer whether in vitro culture decreases the clinical value of perinatal mesenchymal stem cells or increases any risk for the clinical application. Preclinical studies and clinical data, quality control, and potential risk factors for manufacturing and clinical application will be discussed in this chapter.

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Copyright information

© Springer Nature Singapore Pte Ltd. 2019

Authors and Affiliations

  • Youwei Wang
    • 1
  1. 1.Cell Therapy Lab, James Cancer Hospital, Ohio State UniversityColumbusUSA

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