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Prenatal Mesenchymal Stem Cell Secretome and Its Clinical Implication

  • Lu Liang
Chapter

Abstract

Mesenchymal stem cells (MSCs) possess paracrine characteristic involving in the main therapeutic effects. The soluble factors secreted by MSCs are responsible for the paracrine activity, which have attracted more and more attention. These protein factors named secretome could be related to the biological processes such as wound healing, inflammatory response, angiogenesis, cell proliferation, chemotaxis, and neurogenesis. And they have bypassed the confounding issues of MSCs themselves. The MSC secretome in MSC-conditioned media (CM) could be manufactured and used as protein drugs. The cost of manufacturing, transport, and storage of secretome is lower than that of MSCs. Prenatal MSC secretome, especially placenta MSC secretome, has higher concentration and stronger capacities than that of other origins, which is a promising alternative to stem cell therapy for various diseases treatment.

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Copyright information

© Springer Nature Singapore Pte Ltd. 2019

Authors and Affiliations

  • Lu Liang
    • 1
  1. 1.Tianjin Bion Bio-tech Co., Ltd.TianjinChina

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