Retrograde Transneuronal Injury: From the Posterior Optic Pathway to Retinal Ganglion Cells

  • Xiaobin Xie
  • Ning Fan
  • Ningli Wang
Part of the Advances in Visual Science and Eye Diseases book series (AVSED, volume 2)


Retrograde transneuronal injury refers to damage from superior neurons to their inferior neurons across synapse retrogradely in the course of the nerve conduction pathway. In the visual pathway, common pathological changes are those lesions in the lateral geniculate body (LGB), mainly including the vascular lesions, tumor, infections, and trauma on the occipital or temporal lobes, which may lead to damage to the retinal ganglion cells (RGCs) and their axons (nerve fibers). In this section, we will describe two cases and tentatively explore the mechanism.


  1. 1.
    Jindahra P, Petrie A, Plant GT. Retrograde trans-synaptic retinal ganglion cell loss identified by optical coherence tomography. Brain. 2009;132(Pt 3):628–34.CrossRefGoogle Scholar
  2. 2.
    Jindahra P, Petrie A, Plant GT. The time course of retrograde trans-synaptic degeneration following occipital lobe damage in humans. Brain. 2012;135(Pt 2):534–41.CrossRefGoogle Scholar
  3. 3.
    Johnson H, Cowey A. Transneuronal retrograde degeneration of retinal ganglion cells following restricted lesions of striate cortex in the monkey. Exp Brain Res. 2000;132(2):269–75.CrossRefGoogle Scholar

Copyright information

© Springer Nature Singapore Pte Ltd. & People's Medical Publishing House, PR of China 2019

Authors and Affiliations

  • Xiaobin Xie
    • 1
  • Ning Fan
    • 2
  • Ningli Wang
    • 3
  1. 1.Eye Hospital of China Academy of Chinese Medical SciencesBeijingChina
  2. 2.Shenzhen Eye Hospital, Shenzhen UniversityShenzhenChina
  3. 3.Department of OphthalmologyBeijing Tongren Hospital, Capital Medical UniversityBeijingChina

Personalised recommendations