Cellular Signaling in Bacterial Biofilms

  • Abhik Saha
  • Kriti Arora
  • Andaleeb Sajid
  • Gunjan Arora


Development to sedentary community-based complex growth from planktonic growth is one of the most interesting feature of bacterial lifestyle, which is discussed in this chapter. Bacteria have smaller genomes and use simple signaling schemes for such complex transformation. However, diverse bacteria send either specific or shared signals to their neighbors and form complex biofilms in environment and in human host. The interaction between host immunity and antigens associated with bacterial biofilm has been elaborated. The signaling machinery help bacteria modulate transcription, protein synthesis and post-translational modifications that regulate motility and promote adhesion. In this context, the role of Ser/Thr protein kinases such as PrkC is discussed in detail. Biofilms protect the bacteria in harsh conditions, from environmental stress, host immunity and antibiotics, and also alter the virulence patterns. This is one of the most effective way to manipulate host defenses which can lead to development of therapeutic candidates that can alter bacterial signaling machinery and can help in utilizing biofilm formation for medical and industrial proposes.


Bacterial biofilms Cellular signalling Host defence Virulence 


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Copyright information

© Springer Nature Singapore Pte Ltd. 2018

Authors and Affiliations

  • Abhik Saha
    • 1
  • Kriti Arora
    • 2
  • Andaleeb Sajid
    • 2
  • Gunjan Arora
    • 3
  1. 1.Department of Microbiology and Biotechnology CentreThe M. S. University of BarodaVadodaraIndia
  2. 2.Tuberculosis Research SectionNational Institute of Allergy and Infectious Diseases, National Institutes of HealthBethesdaUSA
  3. 3.National Institute of Allergy and Infectious Diseases, National Institutes of HealthRockvilleUSA

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