Choroidal Hemangioma

  • Duangnate RojanapornEmail author
Part of the Retina Atlas book series (RA)


Choroidal hemangioma is a benign vascular harmatoma of the choroid, which is classified into two types, circumscribed choroidal hemangioma and diffuse choroidal hemangioma. Circumscribed choroidal hemangioma is an isolated solitary tumor without systemic association, whereas diffuse choroidal hemangioma is usually associated with Sturge-Weber syndrome. However, there are few cases reports of circumscribed choroidal hemangioma in Sturge-Weber syndrome patients (Scott et al. 1991; Cheung et al. 2000; Shields et al. 2001).


  1. Aizman A, Finger PT, Shabto U, et al. Palladium 103 (103Pd) plaque radiation therapy for circumscribed choroidal hemangioma with retinal detachment. Arch Ophthalmol. 2004;122:1652–6.CrossRefGoogle Scholar
  2. Anand R, Augsburger JJ, Shields JA. Circumscribed choroidal hemangiomas. Arch Ophthalmol. 1989;107:1338–42.CrossRefGoogle Scholar
  3. Arevalo JF, Shields CL, Shields JA, et al. Circumscribed choroidal hemangioma: characteristic features with indocyanine green videoangiography. Ophthalmology. 2000;107:344–50.CrossRefGoogle Scholar
  4. Arevalo JF, Arias JD, Serrano MA. Oral propanolol for exudative retinal detachment in diffuse choroidal hemangioma. Arch Ophthalmol. 2011;129:1373–5.CrossRefGoogle Scholar
  5. Blasi MA, Tiberti AC, Scupola A, et al. Photodynamic therapy with verteporfin for symptomatic circumscribed choroidal hemangioma: five-year outcomes. Ophthalmology. 2010;117:1630–7.CrossRefGoogle Scholar
  6. Cheung D, Grey R, Rennie I. Circumscribed choroidal haemangioma in a patient with Sturge Weber syndrome. Eye (Lond). 2000;14:238–40.CrossRefGoogle Scholar
  7. Dave T, Dave VP, Shah G, et al. Diffuse choroidal hemangioma masqueradingas central serous chorioretinopathy treated with oral propanolol. Retin Cases Brief Rep. 2016;10:11–4.CrossRefGoogle Scholar
  8. Frau E, Rumen F, Noel G, et al. Low-dose proton beam therapy for circumscribed choroidal hemangiomas. Arch Ophthalmol. 2004;122:1471–5.CrossRefGoogle Scholar
  9. Garcia-Arumi J, Ramsay LS, Guraya BC. Transpupillary thermotherapy for circumscribed choroidal hemangiomas. Ophthalmology. 2000;107:351–6.CrossRefGoogle Scholar
  10. Gunduz K. Transpupillary thermotherapy in the management of circumscribed choroidal hemangioma. Surv Ophthalmol. 2004;49:316–27.CrossRefGoogle Scholar
  11. Jurklies B, Anastassiou G, Ortmans S, et al. Photodynamic therapy using verteporfin in circumscribed choroidal haemangioma. Br J Ophthalmol. 2003;87:84–9.CrossRefGoogle Scholar
  12. Kamal A, Watts AR, Rennie IG. Indocyanine green enhanced transpupillary thermotherapy of circumscribed choroidal haemangioma. Eye (Lond). 2000;5:701–5.CrossRefGoogle Scholar
  13. Karimi S, Nourinia R, Mashayekhi A. Circumscribed Choroidal Hemangioma. J Ophthalmic Vis Res. 2015;10:320–8.CrossRefGoogle Scholar
  14. Kong DS, Lee JI, Kang SW. Gamma knife radiosurgery for choroidal hemangioma. Am J Ophthalmol. 2007;144:319–22.CrossRefGoogle Scholar
  15. Kubicka-Trzaska A, Karska-Basta I, Oleksy, et al. Management of diffuse choroidal hemangioma in Sturge-Weber syndrome with Ruthenium-106 plaque radiotherapy. Graefes Arch Clin Exp Ophthalmol. 2015;253:2015–9.CrossRefGoogle Scholar
  16. Lanzetta P, Virgili G, Ferrari E, et al. Diode laser photocoagulation of choroidal hemangioma. Int Ophthalmol. 1995;19:239–47.CrossRefGoogle Scholar
  17. Levy-Gabriel C, Rouic LL, Plancher C, et al. Long-term results of low-dose proton beam therapy for circumscribed choroidal hemangiomas. Retina. 2009;29:170–5.CrossRefGoogle Scholar
  18. Mandal S, Naithani P, Venkatesh P, et al. Intravitreal bevacizumab (avastin) for circumscribed choroidal hemangioma. Indian J Ophthalmol. 2011;59:248–51.CrossRefGoogle Scholar
  19. Mantelli F, Bruscolini A, La Cava M, et al. Ocular manifestations of Sturge-Weber syndrome: pathogenesis, diagnosis, and management. Clin Ophthalmol. 2016;10:871–8.PubMedPubMedCentralGoogle Scholar
  20. Mashayekhi A, Shields CL. Circumscribed choroidal hemangioma. Curr Opin Ophthalmol. 2003;14:142–9.CrossRefGoogle Scholar
  21. Naseripour M, Maleki A, Astaraki A, et al. Ruthenium-106 brachytherapy in the treatment of circumscribed choroidal hemangioma. Retina. 2017;38:1024–30.CrossRefGoogle Scholar
  22. Ramasubramanian A, Shields CL, Harmon SA, et al. Autofluorescence of choroidal hemangioma in 34 consecutive eyes. Retina. 2010;30:16–22.CrossRefGoogle Scholar
  23. Rojanaporn D, Kaliki S, Ferenczy SR, et al. Enhanced depth imaging optical coherence tomography of circumscribed choroidal hemangioma in 10 consecutive cases. Middle East Afr J Ophthalmol. 2015;22:192–7.CrossRefGoogle Scholar
  24. Sagong M, Lee J, Chang W. Application of intravitreal bevacizumab for circumscribed choroidal hemangioma. Korean J Ophthalmol. 2009;23:127–31.CrossRefGoogle Scholar
  25. Sanz-Marco E, Gallego R, Diaz-Llopis M. Oral propranolol for circumscribed choroidal hemangioma. Case Rep Ophthalmol. 2011;2:84–90.CrossRefGoogle Scholar
  26. Schilling BW, Poon TC, Indebetouw G, et al. Three-dimensional holographic fluorescence microscopy. Opt Lett. 1997;22:1506–8.CrossRefGoogle Scholar
  27. Scott TA, Augsburger JJ, Brady LW, et al. Low dose ocular irradiation for diffuse choroidal hemangiomas associated with bullous nonrhegmatogenous retinal detachment. Retina. 1991;11:389.CrossRefGoogle Scholar
  28. Shields JA, Shields CL. Intraocular tumors: an atlas and textbook. 3rd ed. Philadelphia: Wolters Kluwer; 2015.Google Scholar
  29. Shields CL, Shields JA, Gross NE, et al. Survey of 520 eyes with uveal metastases. Ophthalmology. 1997;104:1265–76.CrossRefGoogle Scholar
  30. Shields CL, Honavar SG, Shields JA, et al. Circumscribed choroidal hemangioma: clinical manifestations and factors predictive of visual outcome in 200 consecutive cases. Ophthalmology. 2001;108:2237–48.CrossRefGoogle Scholar
  31. Shields CL, Shields JA, Perez N, et al. Primary transpupillary thermotherapy for small choroidal melanoma in 256 consecutive cases: outcomes and limitations. Ophthalmology. 2002;109:225–34.CrossRefGoogle Scholar
  32. Shields CL, Materin MA, Marr BP, et al. Resolution of advanced cystoid macular edema following photodynamic therapy for choroidal hemangioma. Ophthalmic Surg Lasers Imaging. 2005;36:237–9.CrossRefGoogle Scholar
  33. Singh AD, Kaiser PK, Sears JE, et al. Photodynamic therapy of circumscribed choroidal haemangioma. Br J Ophthalmol. 2004;88:1414–8.CrossRefGoogle Scholar
  34. Tanabe H, Sahashi K, Kitano T, et al. Effects of oral propranolol on circumscribed choroidal hemangioma: a pilot study. JAMA Ophthalmol. 2013;131:1617–22.CrossRefGoogle Scholar
  35. Thapa R, Shields CL. Oral propanolol therapy for management of exudative retinal detachment from diffuse choroidal hemangioma in Sturge-Weber syndrome. Eur J Ophthalmol. 2013;23:922–4.CrossRefGoogle Scholar
  36. Torres VL, Brugnoni N, Kaiser PK, et al. Optical coherence tomography enhanced depth imaging of choroidal tumors. Am J Ophthalmol. 2011;151:586–93.CrossRefGoogle Scholar
  37. Tsipursky MS, Golchet PR, Jampol LM. Photodynamic therapy of choroidal hemangioma in sturge-weber syndrome, with a review of treatments for diffuse and circumscribed choroidal hemangiomas. Surv Ophthalmol. 2011;56:68–85.CrossRefGoogle Scholar
  38. Witschel H, Font RL. Hemangioma of the choroid. A clinicopathologic study of 71 cases and a review of the literature. Surv Ophthalmol. 1976;20:415–31.CrossRefGoogle Scholar
  39. Zhang Y, Liu W, Fang Y, et al. Photodynamic therapy for symptomatic circumscribed macular choroidal hemangioma in Chinese patients. Am J Ophthalmol. 2010;150:710–5.CrossRefGoogle Scholar
  40. Zografos L, Bercher L, Chamot L, et al. Cobalt-60 treatment of choroidal hemangiomas. Am J Ophthalmol. 1996;121:190–9.CrossRefGoogle Scholar
  41. Zografos L, Egger E, Bercher L, et al. Proton beam irradiation of choroidal hemangiomas. Am J Ophthalmol. 1998;126:261–8.CrossRefGoogle Scholar

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© Springer Nature Singapore Pte Ltd. 2019

Authors and Affiliations

  1. 1.Department of Ophthalmology, Faculty of MedicineRamathibodi Hospital, Mahidol UniversityBangkokThailand

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