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Choroidal Melanoma

  • Carol L. Shields
  • Jerry A. Shields
Chapter
Part of the Retina Atlas book series (RA)

Abstract

Melanoma is a dangerous malignancy that can involve the skin, the uvea, and the mucous membranes (Shields et al. 2015b; Shields et al. 2014; Shields and Shields 2015a; Kaliki and Shields 2017; Shields and Shields 2015b; Chang et al. 1998). In a review of 84,836 cases from the National Cancer Data Base, including cases diagnosed between 1985 and 1994, the percentages of melanomas arising from the skin, eye and adnexa, mucosa, and unknown primaries were 91, 5, 1, and 2%, respectively (Chang et al. 1998). In North America, it is estimated that approximately 2500 persons develop uveal melanoma annually (Kivela 2009). Worldwide, it is estimated that there are 7095 new cases of uveal melanoma annually with 4747 in White non-Hispanic, 738 in Hispanic, 1286 in Asian, and 316 in African patients (Kivela 2009). The incidence of uveal melanoma has been relatively stable over past decades.

References

  1. Almeida A, Kaliki S, Shields CL. Autofluorescence of intraocular tumours. Curr Opin Ophthalmol. 2013;24:222–32.CrossRefGoogle Scholar
  2. Chang AE, Karnell LH, Menck HR. The National Cancer Data Base report on cutaneous and noncutaneous melanoma: a summary of 84,836 cases from the past decade. The American College of Surgeons Commission on Cancer and the American Cancer Society. Cancer. 1998;83:1664–78.CrossRefGoogle Scholar
  3. Collaborative Ocular Melanoma Study Group. The COMS randomized trial of iodine 125 brachytherapy for choroidal melanoma: V. twelve-year mortality rates and prognostic factors: COMS report No. 28. Arch Ophthalmol. 2006;124:1684–93.CrossRefGoogle Scholar
  4. Gupta MP, Lane AM, DeAngelis MM, et al. Clinical characteristics of uveal melanoma in patients with germline BAP1 mutations. JAMA Ophthalmol. 2015;133:881–7.CrossRefGoogle Scholar
  5. Hawkins BS. The Collaborative Ocular Melanoma Study (COMS) randomized trial of pre-enucleation radiation of large choroidal melanoma: IV. Ten-year mortality findings and prognostic factors. COMS report number 24. Am J Ophthalmol. 2004;138:936–51.CrossRefGoogle Scholar
  6. Kaliki S, Shields CL. Uveal melanoma: relatively rare but deadly cancer. Eye (Lond). 2017;31:241–57.CrossRefGoogle Scholar
  7. Kivela T. The epidemiological challenge of the most frequent eye cancer: retinoblastoma, an issue of birth and death. Br J Ophthalmol. 2009;93:1129–31.CrossRefGoogle Scholar
  8. Kujala E, Damato B, Coupland SE, et al. Staging of ciliary body and choroidal melanomas based on anatomic extent. J Clin Oncol. 2013;31:2825–31.CrossRefGoogle Scholar
  9. Mashayekhi A, Shields CL, Rishi P, Shields JA, et al. Primary transpupillary thermotherapy for choroidal melanoma in 391 cases: importance of risk factors in tumor control. Ophthalmology. 2015;122:600–9.CrossRefGoogle Scholar
  10. Prescher G, Bornfeld N, Hirche H, et al. Prognostic implications of monosomy 3 in uveal melanoma. Lancet. 1996;347:1222–5.CrossRefGoogle Scholar
  11. Qiu M, Shields CL. Choroidal nevus in the United States adult population: racial disparities and associated factors in the national health and nutrition examination survey. Ophthalmology. 2015;122:2071–83.CrossRefGoogle Scholar
  12. Rai K, Pilarski R, Cebulla CM, et al. Comprehensive review of BAP1 tumor predisposition syndrome with report of two new cases. Clin Genet. 2016;89:285–94.CrossRefGoogle Scholar
  13. Rishi P, Shields CL, Khan MA, et al. Headache or eye pain as the presenting feature of uveal melanoma. Ophthalmology. 2013;120:1946–7.CrossRefGoogle Scholar
  14. Sagoo MS, Shields CL, Mashayekhi A, et al. Plaque radiotherapy for choroidal melanoma encircling the optic disc (circumpapillary choroidal melanoma). Arch Ophthalmol. 2007;125:1202–9.CrossRefGoogle Scholar
  15. Sagoo MS, Shields CL, Mashayekhi A, et al. Plaque radiotherapy for juxtapapillary choroidal melanoma overhanging the optic disc in 141 consecutive patients. Arch Ophthalmol. 2008;126:1515–22.CrossRefGoogle Scholar
  16. Sagoo MS, Shields CL, Mashayekhi A, et al. Plaque radiotherapy for juxtapapillary choroidal melanoma: tumor control in 650 consecutive cases. Ophthalmology. 2011;118:402–7.CrossRefGoogle Scholar
  17. Shah CP, Weis E, Lajous M, et al. Intermittent and chronic ultraviolet light exposure and uveal melanoma: a meta-analysis. Ophthalmology. 2005;112:1599–607.CrossRefGoogle Scholar
  18. Shields JA, Shields CL. Intraocular tumors: an atlas and textbook. 3rd ed. Philadelphia: Wolters Kluwer; 2015a.Google Scholar
  19. Shields JA, Shields CL. Management of posterior uveal melanoma: past, present, and future: the 2014 Charles L. Schepens lecture. Ophthalmology. 2015b;122:414–28.CrossRefGoogle Scholar
  20. Shields JA, Shields CL, Ehya H, et al. Fine-needle aspiration biopsy of suspected intraocular tumors. The 1992 Urwick lecture. Ophthalmology. 1993;100:1677–84.CrossRefGoogle Scholar
  21. Shields CL, Shields JA, Kiratli H, et al. Risk factors for growth and metastasis of small choroidal melanocytic lesions. Trans Am Ophthalmol Soc. 1995;93:259–75.PubMedPubMedCentralGoogle Scholar
  22. Shields CL, Cater J, Shields JA, et al. Combination of clinical factors predictive of growth of small choroidal melanocytic tumors. Arch Ophthalmol. 2000a;118:360–4.CrossRefGoogle Scholar
  23. Shields CL, Shields JA, Cater J, et al. Plaque radiotherapy for uveal melanoma: long-term visual outcome in 1106 consecutive patients. Arch Ophthalmol. 2000b;118:1219–28.CrossRefGoogle Scholar
  24. Shields JA, Mashayekhi A, Ra S, et al. Pseudomelanomas of the posterior uveal tract: the 2006 Taylor R. smith lecture. Retina. 2005;25:767–71.CrossRefGoogle Scholar
  25. Shields CL, Furuta M, Berman EL, et al. Choroidal nevus transformation into melanoma: analysis of 2514 consecutive cases. Arch Ophthalmol. 2009a;127:981–7.CrossRefGoogle Scholar
  26. Shields CL, Furuta M, Thangappan A, et al. Metastasis of uveal melanoma millimeter-by-millimeter in 8033 consecutive eyes. Arch Ophthalmol. 2009b;127:989–98.CrossRefGoogle Scholar
  27. Shields CL, Kaliki S, Furuta M, et al. Clinical spectrum and prognosis of uveal melanoma based on age at presentation in 8,033 cases. Retina. 2012a;32:1363–72.CrossRefGoogle Scholar
  28. Shields CL, Kaliki S, Rojanaporn D, et al. Enhanced depth imaging optical coherence tomography of small choroidal melanoma: comparison with choroidal nevus. Arch Ophthalmol. 2012b;130:850–6.CrossRefGoogle Scholar
  29. Shields CL, Kaliki S, Furuta M, et al. American joint committee on cancer classification of posterior uveal melanoma (tumor size category) predicts prognosis in 7731 patients. Ophthalmology. 2013a;120:2066–71.CrossRefGoogle Scholar
  30. Shields CL, Kaliki S, Furuta M, et al. Diffuse versus nondiffuse small (</= 3 MM thickness) choroidal melanoma: comparative analysis in 1,751 cases. The 2012 F. Phinizy Calhoun lecture. Retina. 2013b;33:1763–76.CrossRefGoogle Scholar
  31. Shields CL, Kaliki S, Livesey M, et al. Association of ocular and oculodermal melanocytosis with the rate of uveal melanoma metastasis: analysis of 7872 consecutive eyes. JAMA Ophthalmol. 2013c;131:993–1003.CrossRefGoogle Scholar
  32. Shields CL, Manalac J, Das C, et al. Choroidal melanoma: clinical features, classification, and top 10 pseudomelanomas. Curr Opin Ophthalmol. 2014;25:177–85.CrossRefGoogle Scholar
  33. Shields CL, Kaliki S, Furuta M, et al. American joint committee on cancer classification of uveal melanoma (anatomic stage) predicts prognosis in 7,731 patients: the 2013 Zimmerman lecture. Ophthalmology. 2015a;122:1180–6.CrossRefGoogle Scholar
  34. Shields CL, Kels JG, Shields JA. Melanoma of the eye: revealing hidden secrets, one at a time. Clin Dermatol. 2015b;33:183–96.CrossRefGoogle Scholar
  35. Shields CL, Say EAT, Hasanreisoglu M, Saktanasate J, Lawson BM, Landy JE, Badami AU, Sivalingam MD, Mashayekhi A, Shields JA, Ganguly A. Cytogenetic abnormalities in uveal melanoma based on tumor features and size in 1059 patients: the 2016 W. Richard green lecture. Ophthalmology. 2017;124:609–18.CrossRefGoogle Scholar
  36. Singh AD, Topham A. Incidence of uveal melanoma in the United States: 1973-1997. Ophthalmology. 2003;110:956–61.CrossRefGoogle Scholar
  37. Singh AD, De Potter P, Fijal BA, et al. Lifetime prevalence of uveal melanoma in white patients with oculo(dermal) melanocytosis. Ophthalmology. 1998;105:195–8.CrossRefGoogle Scholar
  38. Singh AD, Kalyani P, Topham A. Estimating the risk of malignant transformation of a choroidal nevus. Ophthalmology. 2005;112:1784–9.CrossRefGoogle Scholar
  39. The Collaborative Ocular Melanoma Study Group. Factors predictive of growth and treatment of small choroidal melanoma: COMS report no. 5. Arch Ophthalmol. 1997;115:1537–44.CrossRefGoogle Scholar
  40. Tschentscher F, Husing J, Holter T, et al. Tumor classification based on gene expression profiling shows that uveal melanomas with and without monosomy 3 represent two distinct entities. Cancer Res. 2003;63:2578–84.PubMedGoogle Scholar
  41. Walter SD, Chao DL, Feuer W, et al. Prognostic implications of tumor diameter in association with gene expression profile for uveal melanoma. JAMA Ophthalmol. 2016;134:734–40.CrossRefGoogle Scholar
  42. Weis E, Shah CP, Lajous M, et al. The association between host susceptibility factors and uveal melanoma: a meta-analysis. Arch Ophthalmol. 2006;124:54–60.CrossRefGoogle Scholar

Copyright information

© Springer Nature Singapore Pte Ltd. 2019

Authors and Affiliations

  • Carol L. Shields
    • 1
    • 2
  • Jerry A. Shields
    • 1
    • 2
  1. 1.Ocular Oncology ServiceWills Eye HospitalPhiladelphiaUSA
  2. 2.Department of OphthalmologyThomas Jefferson UnversityPhiladelphiaUSA

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