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Pharmacology of a Critically Ill Child and Drug Dosing

  • Joshua ZaritskyEmail author
  • Carl Gerdine
Chapter

Abstract

Pharmacology in critically ill children and drug dosing adjustment during renal replacement therapy is an important aspect. This practical chapter shall focus on factors affecting drug removal during renal replacement therapy followed by a practical approach to drug delivery in renal replacement therapy.

References

  1. 1.
    Smith BS, Yogaratnam D, Levasseur-Franklin E, et al. Introduction to drug pharmacokinetics in the critically ill patient. Chest. 2012;141(5):1327–36.CrossRefGoogle Scholar
  2. 2.
    Vincent HH, Vos MC, Akcahuseyin E, et al. Drug clearance by continuous haemodiafiltration: analysis of sieving coefficients and mass transfer coefficients of diffusion. Blood Purif. 1993;11:99–107.CrossRefGoogle Scholar
  3. 3.
    Reetze-Bonorden P, Bohler J, Keller E. Drug dosage in patients during continuous renal replacement therapy: pharmacokinetic and therapeutic considerations. Clin Pharmacokinet. 1993;24:362–79.CrossRefGoogle Scholar
  4. 4.
    Schetz M, Ferdinande P, Van den Berghe G, et al. Pharmacokinetics of continuous renal replacement therapy. Intensive Care Med. 1995;21:612–20.CrossRefGoogle Scholar
  5. 5.
    Aronoff GR, Bennett WM, Berns JS, et al. Drug prescribing in renal failure: dosing guidelines for adults and children. 5th ed. Philadelphia, PA: American College of Physicians; 2007.Google Scholar
  6. 6.
    Kempke AP, Leino AS, Daneshvar F, Lee JA, Mueller BA. Antimicrobial doses in continuous renal replacement therapy: a comparison of dosing strategies. Crit Care Res Pract. 2016;2016:6.Google Scholar
  7. 7.
    Trotman RL, et al. Antibiotic dosing in critically ill adult patients receiving continuous renal replacement therapy. Clin Infect Dis. 2005;41:1159–66.CrossRefGoogle Scholar
  8. 8.
    Pea F, et al. Pharmacokinetic considerations for antimicrobial therapy in patients receiving renal replacement therapy. Clin Pharmacokinet. 2007;46:997–1038.CrossRefGoogle Scholar
  9. 9.
    Heintz BH, et al. Antimicrobial dosing concepts and recommendations for critically ill adult patients receiving continuous renal replacement therapy or intermittent hemodialysis. Pharmacotherapy. 2009;29:562–77.CrossRefGoogle Scholar
  10. 10.
    Kroh UF. Drug administration in critically ill patients with acute renal failure. New Horiz. 1995;3:748–59.PubMedGoogle Scholar

Copyright information

© Springer Nature Singapore Pte Ltd. 2019

Authors and Affiliations

  1. 1.Pediatric NephrologyNemours/A.I. duPont Hospital for ChildrenWilmingtonUSA
  2. 2.Pediatric Cardiac Intensive CareNemours/A.I. duPont Hospital for ChildrenWilmingtonUSA

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