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Sepsis-Associated Acute Kidney Injury

  • Rashid Alobaidi
  • Sean M. BagshawEmail author
Chapter

Abstract

Acute kidney injury (AKI) is commonly encountered and contributes to high burden of morbidity and mortality during critical illness. On the other hand, sepsis remains highly prevalent and the leading cause of non-trauma-related mortality in children. Sepsis carries a strong association with the development of AKI and accounts for approximately quarter of the cases of pediatrics AKI. Sepsis-associated acute kidney injury (SA-AKI) is a serious complication that exacerbates an already less than favorable outcome in patients with sepsis. Several pathophysiological mechanisms have been described to suggest that SA-AKI represents a distinct subclass of AKI precipitated by alterations in renal microvascular mechanisms and immune-mediated injury. There is no single modality of treatment that can alter the natural course of SA-AKI, making it a challenging clinical problem. The general principals of SA-AKI management focus on early risk identification, fluid resuscitation, and appropriate antimicrobial administration, followed by a strategy of limiting injury, avoiding life-threatening complications, eliminating any potential contributors to worsening kidney function and facilitating recovery.

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Copyright information

© Springer Nature Singapore Pte Ltd. 2019

Authors and Affiliations

  1. 1.Department of Pediatrics, Division of Pediatric Critical Care Medicine, Faculty of Medicine and DentistryUniversity of AlbertaEdmontonCanada
  2. 2.Department of Critical Care Medicine, Faculty of Medicine and DentistryUniversity of AlbertaEdmontonCanada

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