Waste slurry is an inevitable product of construction and is characterized by high water content, high content of fine particles, high void ratio, and extremely low strength. Its treatment requires consideration of the economic and environmental implications. In this paper, vacuum filtration test was conducted indoor to investigate the effect of volume reduction and consolidation behaviors of waste slurry. The monitored parameters included the filtration rate, height of slurry surface, solid content of filtrate, and moisture content of slurry column after testing. The effect of vacuum filtration is remarkable: the volume of slurry (desanding) and slurry (with sand) decreased by 80% and 63.3% respectively after 10 days’ test, the filtrate was comparatively clear and the solid content were only 0.17% and 0.14%, and the moisture content of the bottom of the slurry column was reduced to 53.31% and 45.97% respectively, which is equivalent to the moisture content of the soft soil.