Drug Therapy in Hydatid Disease of the Liver

  • Ajaz Ahmad Malik
  • Shams ul Bari


Medical management of hydatidosis has been tried with many drugs including antimony, arsenic, iodides and mercury (Arif et al. 2008). However there was no evidence of any success. Lately the benzimidazole carbamate group of drugs was introduced and was found effective against larval stage of both E. granulosus and E. multilocularis. This benzimidazole carbamate group of drugs blocks the uptake of glucose in the parasite, thereby causing depletion of its glycogen stores (Arif et al. 2008). The drug causes death of germinal membrane cells, and the cyst loses its ability to maintain haemostasis and integrity (Heath et al. 1975).


  1. Amir-Jehad AK, Faria R, Furzad R. Clinical echinococcus. Ann Surg. 1975;182:541–5.CrossRefGoogle Scholar
  2. Arif SH, bari S u, Wani NA, Zargar SA. Albendazole as an adjuvant to the standard surgical management of hydatid cyst liver. Int J Surg. 2008;6(6):448–51.CrossRefGoogle Scholar
  3. Bari S, S H, Malik AA, Rouf KA, Tufale AD, Zahoor AN. Role of albendazole in the management of hydatid cyst liver. Saudi J Gastroenterol. 2011;17(5):343–7.CrossRefGoogle Scholar
  4. Bekhti A, Schaaps JP, Capron M, Dessaint JP, Santoro F, Capron A. Treatment of hepatic hydatid disease with mebendazole: preliminary results in four cases. Br Med J. 1977;ii:1047–51.CrossRefGoogle Scholar
  5. Braithwaite PA. Long term high dose mebendazole for cystic disease of liver: failure in two cases. Aust N Z J Surg. 1981;51:23–7.CrossRefGoogle Scholar
  6. Braithwaite PA, Roberts MS, Allan RJ. Clinical pharmacokinetics of high dose of mebendazole in patients treated for cystic hydatid disease. Eur J Clin Pharmacol. 1982;22:101–9.CrossRefGoogle Scholar
  7. El-Mufti M. Surgical management of hydatid disease. London: Butterworths; 1989.Google Scholar
  8. El-Mufti M, karnag HA, Ibrahim S, Taktuk I, Swaisi AZ. Albendazole therapy of hydatid disease: 2-year follow-up of 40 cases. Ann Trop Med Parasitol. 1993;87(3):241–6.CrossRefGoogle Scholar
  9. Evangelos C, et al. Perioperative benzimidazole therapy in human hydatid liver disease. Int Surg. 1995;80:131–3.Google Scholar
  10. French CM. Mebendazole and surgery for human hydatid disease in Turkana. East Afr Med J. 1984;61:113–9.PubMedGoogle Scholar
  11. Heath DD, Christie MJ, Chevisn RAF. The lethal effect of albendazole on secondary Echinococcus granulosus, cysticerici od taeniasis pisiformis and tetrathyridia of mesocestoides corti. Parasitology. 1975;70:273–385.CrossRefGoogle Scholar
  12. Horton RJ. Chemotherapyof echinoccoccus infection in man with albendazole. Trans R Soc Trop Med Hyg. 1989;83:97–102.CrossRefGoogle Scholar
  13. Khuroo MS. Hydatid disease: current status and recent advances. Ann Saudi Med. 2002;22:56–64.CrossRefGoogle Scholar
  14. Little JM, Hollands MT, Eckberg H. Recurrence of hydatid disease. World J Surg. 1988;12:700–70.CrossRefGoogle Scholar
  15. Milicevic MN. Hydatid disease. In: Blumgart LH, Fong Y, editors. Surgery of liver and biliary tract. 3rd ed. London: W.B. Saunders; 2000.Google Scholar
  16. Morris DL. Preoperative albendazole therapy for hydatid cyst. Br J Surg. 1987;74:805–6.CrossRefGoogle Scholar
  17. Morris DL. Albendazole treatment of hydatid disease: follow up at five years. Trop Doct. 1989;19:179–80.CrossRefGoogle Scholar
  18. Morris DL, Gould SE. Serum and cyst concentrations of mebendazole and flubendazole in hydatid disease. Br Med J (Clin Res Ed). 1982;285:175.CrossRefGoogle Scholar
  19. Morris DL, Taylor DH. Optimal timing of postoperative albendazole prophylaxis in E. granulosus. Ann Trop Med Parasitol. 1988;82:65–6.CrossRefGoogle Scholar
  20. Morris DL, Skeene-Smith H, Haynes A, Burrows FGO. Abdominal hydatid disease: computed tomographic and ultrasound changes during albendazole therapy. Clin Radiol. 1984;35:297–300.CrossRefGoogle Scholar
  21. Morris DL, Dykes PW, Marriner S, Bogan J, Burrows F, Skeene-Smith H, Clarkson MJ. Albendazole: objective evidence of response in human hydatid disease. J Am Med Assoc. 1985;253:2053–7.CrossRefGoogle Scholar
  22. Morris DL, Chinnery JB, et al. Penetration of albendazole sulphoxide into hydatid cyst. Gut. 1987;28:75–80.CrossRefGoogle Scholar
  23. Mottaghion H, Saidi F. Postoperative recurrence of hydayod disease. Br J Surg. 1978;65:237–42.CrossRefGoogle Scholar
  24. Okelo GBA. Hydatid disease: research and control in Turkana: III—Albendazole in the treatment of inoperable hydatid disease in Kenya; a report on 12 cases. Trans R Soc Trop Med Hyg. 1986;80:193–5.CrossRefGoogle Scholar
  25. Osborne DR. Mebendazole and hydatid disease. Br Med J. 1980;280:183.CrossRefGoogle Scholar
  26. Saimot AG, Meulemans A, Cremieux AC, Giovangeli MD, Hay JM, Delaitre B, Coulaund JP. Albendazole as a potential treatment for human hydatidosis. Lancet. 1983;ii:652–6.CrossRefGoogle Scholar
  27. Schantz PM, Van den Bossche H, Eckert J. Chemotherapy for larval Echinococcosis in animals and humans. Report of workshop. Zeitschrift fuer Parasitenkunde. 1982;67:5–26.CrossRefGoogle Scholar
  28. Sherlock S. Hydatid disease: disease of liver and biliary system. Oxford: Blackwell Scientific; 1981. p. 247–452.Google Scholar
  29. Taylor DH, Morris DL, Richards KS. Combination chemotherapy of Echinococcus granulosus—in vitro studies. Trans R Soc Trop Med Hyg. 1988;82:263–4.CrossRefGoogle Scholar
  30. Taylor DH, Morris DL, Reffin D, Richards KS. Comparison of albendazole, mebendazole and praziquantel chemotherapy of Echinococcus multilocularis in gerbil model. Gut. 1989;30:1401–5.CrossRefGoogle Scholar
  31. Wilson JF, Rausch RL. Alveolar hydatid disease; A review of the clinical features of 33 indigenous cases of Echinococcus multilocularis Infections in Alaskan Eskimos. Am J Trop Med Hyg. 1980;24:1340–55.CrossRefGoogle Scholar

Copyright information

© Springer Nature Singapore Pte Ltd. 2019

Authors and Affiliations

  • Ajaz Ahmad Malik
    • 1
  • Shams ul Bari
    • 2
  1. 1.Department of SurgerySheri-Kashmir Institute of Medical Sciences (SKIMS)SrinagarIndia
  2. 2.Department of SurgerySkims/Skims Medical college SrinagarIndia

Personalised recommendations