The New Concepts of Cerebrospinal Fluid Physiology
The description of cerebrospinal fluid first appeared in the 17th century BC . An antique dealer named Edwin Smith bought a surgical papyrus which described the watery fluid around the brain. In 1747, Albrecht von Haller, a Swiss anatomist and physiologist, first described the existence of CSF systematically . Subsequently, Cotugno, an Italian anatomist from Naples, observed the presence of water (“liquor cotunnii”) around the ventricles and the spinal cord by conducting 20 autopsies . Also, he found that the brain gets smaller in size and the volume of watery fluid around the ventricles and the spinal cord increases with age increase. His notable observations were published in Latin in 1764 in Naples and in English in 1775 in London. The term cerebrospinal fluid in published literature is “le liquid cérébrospinal” in a French document by Magendie in 1842 .
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