The New Concepts of Cerebrospinal Fluid Physiology

  • Jiawei Wang
  • Ningli WangEmail author
Part of the Advances in Visual Science and Eye Diseases book series (AVSED, volume 1)


The description of cerebrospinal fluid first appeared in the 17th century BC [1]. An antique dealer named Edwin Smith bought a surgical papyrus which described the watery fluid around the brain. In 1747, Albrecht von Haller, a Swiss anatomist and physiologist, first described the existence of CSF systematically [2]. Subsequently, Cotugno, an Italian anatomist from Naples, observed the presence of water (“liquor cotunnii”) around the ventricles and the spinal cord by conducting 20 autopsies [3]. Also, he found that the brain gets smaller in size and the volume of watery fluid around the ventricles and the spinal cord increases with age increase. His notable observations were published in Latin in 1764 in Naples and in English in 1775 in London. The term cerebrospinal fluid in published literature is “le liquid cérébrospinal” in a French document by Magendie in 1842 [4].


  1. 1.
    Deisenhammer F, Sellebjerg F, Teunissen CE, Tumani H (eds). Cerebrospinal fluid in clinical neurology, 2015; pp 3–6.Google Scholar
  2. 2.
    Matsumae M, Sato O, Hirayama A, et al. Research into the physiology of cerebrospinal fluid reaches a New Horizon: intimate exchange between cerebrospinal fluid and interstitial fluid may contribute to maintenance of homeostasis in the central nervous system[J]. Neurol Med Chir. 2016;56(7):416–41.CrossRefGoogle Scholar
  3. 3.
    Di Ieva A, Yasargil MG. Liquor cotunnii: the history of cerebrospinal fluid in Domenico Cotugno’s work[J]. Neurosurgery. 2008;63(2):352–8.CrossRefGoogle Scholar
  4. 4.
    Magendie F. Recherches physiologiques et cliniques sur le liquide céphalo-rachidien ou cérébro-spinal[M]. Méquignon-Marvis fils. 1842.Google Scholar
  5. 5.
    Key A, Retzius G. Studien in der Anatomie des Nervensystemes[J]. Arch Mikrosk Anat. 1873;9(1):308–86.CrossRefGoogle Scholar
  6. 6.
    Dandy WE, Blackfan KD. An experimental and clinical study of internal hydrocephalus[J]. J Am Med Assoc. 1913;61(25):2216–7.CrossRefGoogle Scholar
  7. 7.
    Cushing H. Studies in intracranial physiology & surgery: the third circulation, the hypophysics, the gliomas [M]. H. Milford, Oxford University Press, 1926.Google Scholar
  8. 8.
    Bering EA. Cerebrospinal fluid production and its relationship to cerebral metabolism and cerebral blood flow[J]. American Journal of Physiology—Legacy Content. 1959;197(4):825–8.CrossRefGoogle Scholar
  9. 9.
    Bering EA Jr, Sato O. Hydrocephalus: Changes in Formation and Absorption of Cerebrospinal Fluid Within the Cerebral Ventricles*[J]. J Neurosurg. 1963;20(12):1050–63.CrossRefGoogle Scholar
  10. 10.
    Weed LH. Studies on cerebro-spinal fluid. No. IV: the dual source of cerebro-spinal fluid[J]. J Med Res. 1914;31(1):93.PubMedPubMedCentralGoogle Scholar
  11. 11.
    Hassin GB. The morphology of the pial blood vessels and its bearing on the formation and absorption of the cerebrospinal fluid[J]. J Neuropathol Exp Neurol. 1948;7(4):432–8.CrossRefGoogle Scholar
  12. 12.
    Sato O, Asai T, Amano Y, et al. Formation of cerebrospinal fluid in spinal subarachnoid space[J]. Nature. 1971;233:129–30.CrossRefGoogle Scholar
  13. 13.
    Sonnenberg H, Solomon S, Frazier DT. Sodium and chloride movement into the central canal of cat spinal cord[J]. Exp Biol Med. 1967;124(4):1316–20.CrossRefGoogle Scholar
  14. 14.
    Orešković D, Klarica M. The formation of cerebrospinal fluid: nearly a hundred years of interpretations and misinterpretations[J]. Brain Res Rev. 2010;64(2):241–62.CrossRefGoogle Scholar
  15. 15.
    Preston GM, Agre P. Appearance of water channels in Xenopus oocytes expressing red cell CHIP28 protein[J]. Science. 1992;256(5055):385.CrossRefGoogle Scholar
  16. 16.
    Igarashi H, Tsujita M, Kwee IL, et al. Water influx into cerebrospinal fluid is primarily controlled by aquaporin-4, not by aquaporin-1: 17O JJVCPE MRI study in knockout mice[J]. Neuroreport. 2014;25(1):39–43.PubMedPubMedCentralGoogle Scholar
  17. 17.
    Brinker T, Stopa E, Morrison J, et al. A new look at cerebrospinal fluid circulation[J]. Fluids and Barriers of the CNS. 2014;11(1):1.CrossRefGoogle Scholar
  18. 18.
    Orešković D, Klarica M. A new look at cerebrospinal fluid movement[J]. Fluids and Barriers of the CNS. 2014;11(1):1.CrossRefGoogle Scholar
  19. 19.
    Yamada S, Kelly E. Cerebrospinal fluid dynamics and the pathophysiology of hydrocephalus: new concepts[C]. Semin Ultrasound, CT and MRI. WB Saunders. 2016;37(2): 84–91.Google Scholar
  20. 20.
    Hladky SB, Barrand MA. Mechanisms of fluid movement into, through and out of the brain: evaluation of the evidence[J]. Fluids and Barriers of the CNS. 2014;11(1):1.CrossRefGoogle Scholar
  21. 21.
    Rangel-Castillo L, Gopinath S, Robertson CS. Management of intracranial hypertension[J]. Neurol Clin. 2008;26(2):521–41.CrossRefGoogle Scholar

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© Springer Nature Singapore Pte Ltd. 2019

Authors and Affiliations

  1. 1.Department of Neurology and Medical Research CenterBeijing Tongren Hospital, Capital Medical UniversityBeijingChina
  2. 2.Beijing Institute of Ophthalmology, Beijing Tongren Eye CenterBeijing Tongren Hospital, Capital Medical UniversityBeijingChina

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