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Biomechanical Mechanisms of IOP-/CSFP-Induced Optic Nerve Damage

  • Yingyan Mao
  • Ningli WangEmail author
Chapter
Part of the Advances in Visual Science and Eye Diseases book series (AVSED, volume 1)

Abstract

Glaucoma, which is characterized by loss of retinal ganglion cell death, is a leading cause of irreversible world vision loss. Traditionally, intraocular pressure (IOP) is considered as the main reason that glaucomatous optic neuropathy develops [1]. However, as well as an elevated IOP, a low cerebrospinal fluid pressure (CSFP) has been proved to be another factor that related to the pathogenesis of glaucomatous optic neuropathy, especially in normal-IOP glaucoma patients [2–10]. The trans-lamina cribrosa pressure difference (TLCPD), which is defined as IOP minus CSFP, may be more important for the development of glaucomatous optic neuropathy [3, 5–8, 11–14]. Study on the damage of optic nerve in reduced CSFP animal models has further supported the hypothesis [15, 16]. However, mechanism of reduced CSFP on the optic nerve damage has not been elucidated yet.

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Copyright information

© Springer Nature Singapore Pte Ltd. 2019

Authors and Affiliations

  1. 1.Beijing Institute of Ophthalmology, Beijing Tongren Eye Center, Beijing Tongren HospitalCapital Medical UniversityBeijingChina
  2. 2.Beijing Ophthalmology & Visual Sciences Key LaboratoryBeijingChina

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