Advertisement

Intraocular Pressure-Related Factors, Retinal Vessel Diameter, and Optic Disc Rim Area

  • Qing Zhang
  • Chen Xin
  • Chunyu Guo
  • Ye Zhang
  • Ningli WangEmail author
Chapter
Part of the Advances in Visual Science and Eye Diseases book series (AVSED, volume 1)

Abstract

Although elevated intraocular pressure (IOP) is a main risk factor, more and more attention has been paid to other factors contributing to the development and progression of primary open-angle glaucoma (POAG) [1–16]. Among those factors, narrow retinal vessels and IOP-related stress have been found associated with glaucomatous optic neuropathy in many clinical trials and population-based study, which furnishes the basis for the vascular mechanism of POAG [1–7]. Lower lumbar cerebrospinal fluid pressure (CSFP) and narrower orbital cerebrospinal fluid space are found in some normal-tension glaucoma patients, compared with normal subjects and POAG with high IOP [13]. Higher CSFP was found relevant to higher body mass index (BMI), and BMI has been reported to be positively correlated with neuroretinal rim area and retinal nerve fiber layer thickness [10–13, 17]. A proven formula was employed to estimate the CSFP in the Central India Eye and Medical Study, instead of the direct measurement which lacks feasibility in such a population-based study. The same formula was also used in the Beijing Eye Study [8, 18, 19]. Along with the CSFP, the trans-lamina cribrosa pressure difference (TLCPD: IOP minus estimated CSFP) was also estimated. A lower estimated CSFP and a higher TLCPD were found associated with the presence of POAG and the severity of optic nerve damage [8, 9, 18].

References

  1. 1.
    Amerasinghe N, Aung T, Cheung N, et al. Evidence of retinal vascular narrowing in glaucomatous eyes in an Asian population. Invest Ophthalmol Vis Sci. 2008;49:5397–402.CrossRefGoogle Scholar
  2. 2.
    Kawasaki R, Wang JJ, Rochtchina E, Lee AJ, Wong TY, Mitchell P. Retinal vessel calibre is associated with the 10-year incidence of glaucoma: the Blue Mountains Eye Study. Ophthalmology. 2013;120:84–90.CrossRefGoogle Scholar
  3. 3.
    Zheng Y, Cheung N, Aung T, Mitchell P, He M, Wong TY. Relationship of retinal vascular caliber with retinal nerve fiber layer thickness: the Singapore Malay Eye Study. Invest Ophthalmol Vis Sci. 2009;50:4091–6.CrossRefGoogle Scholar
  4. 4.
    Wang S, Xu L, Wang Y, Wang Y, Jonas JB. Retinal vessel diameter in normal and glaucomatous eyes: the Beijing eye study. Clin Experiment Ophthalmol. 2007;35:800–7.CrossRefGoogle Scholar
  5. 5.
    Mitchell P, Leung H, Wang JJ, et al. Retinal vessel diameter and open-angle glaucoma: the Blue Mountains Eye Study. Ophthalmology. 2005;112:245–50.CrossRefGoogle Scholar
  6. 6.
    Flammer J, Orgul S, Costa VP, et al. The impact of ocular blood flow in glaucoma. Prog Retin Eye Res. 2002;21:359–93.CrossRefGoogle Scholar
  7. 7.
    Wang JJ, Mitchell P, Smith W. Is there an association between migraine headache and open-angle glaucoma? Findings from the Blue Mountains Eye Study. Ophthalmology. 1997;104:1714–9.CrossRefGoogle Scholar
  8. 8.
    Jonas JB, Wang N, Yang D, Ritch R, Panda-Jonas S. Facts and myths of cerebrospinal fluid pressure for the physiology of the eye. Prog Retin Eye Res. 2015;46:67–83.CrossRefGoogle Scholar
  9. 9.
    Jonas JB, Wang N, Wang YX, et al. Estimated trans-lamina cribrosa pressure difference versus intraocular pressure as biomarker for open-angle glaucoma: The Beijing Eye Study 2011. Acta Ophthalmol. 2015;93(1):e7–e13.CrossRefGoogle Scholar
  10. 10.
    Jonas JB, Nangia V, Gupta R, et al. Retinal nerve fibre layer cross-sectional area, neuroretinal rim area and body mass index. Acta Ophthalmol. 2014;92:e194–9.CrossRefGoogle Scholar
  11. 11.
    Ren R, Wang N, Zhang X, Tian G, Jonas JB. Cerebrospinal fluid pressure correlated with body mass index. Graefes Arch Clin Exp Ophthalmol. 2012;250:445–6.CrossRefGoogle Scholar
  12. 12.
    Ren R, Wang N, Zhang X, Cui T, Jonas JB. Trans-lamina cribrosa pressure difference correlated with neuroretinal rim area in glaucoma. Graefes Arch Clin Exp Ophthalmol. 2011;249:1057–63.CrossRefGoogle Scholar
  13. 13.
    Ren R, Jonas JB, Tian G, et al. Cerebrospinal fluid pressure in glaucoma: a prospective study. Ophthalmology. 2010;117:259–66.CrossRefGoogle Scholar
  14. 14.
    Wang N, Xie X, Yang D, et al. Orbital cerebrospinal fluid space in glaucoma: the Beijing intracranial and intraocular pressure (iCOP) study. Ophthalmology. 2012;119:2065–73.. e2061CrossRefGoogle Scholar
  15. 15.
    Yang H, Williams G, Downs JC, et al. Posterior (outward) migration of the lamina cribrosa and early cupping in monkey experimental glaucoma. Invest Ophthalmol Vis Sci. 2011;52:7109–21.CrossRefGoogle Scholar
  16. 16.
    Yang H, Thompson H, Roberts MD, Sigal IA, Downs JC, Burgoyne CF. Deformation of the early glaucomatous monkey optic nerve head connective tissue after acute IOP elevation in 3-D histomorphometric reconstructions. Invest Ophthalmol Vis Sci. 2011;52:345–63.CrossRefGoogle Scholar
  17. 17.
    Jonas JB, Xu L, Xu J, Wei WB, Wang YX. Prevalence of diabetic retinopathy and vision loss in the Beijing Eye Study: the potential role of the cerebrospinal fluid pressure. Curr Diab Rep. 2015;15:71.CrossRefGoogle Scholar
  18. 18.
    Jonas JB, Nangia V, Wang N, et al. Trans-lamina cribrosa pressure difference and open-angle glaucoma. The central India eye and medical study. PLoS One. 2013;8:e82284.CrossRefGoogle Scholar
  19. 19.
    Liang YB, Friedman DS, Wong TY, et al. Rationale, design, methodology, and baseline data of a population-based study in rural China: the Handan Eye Study. Ophthalmic Epidemiol. 2009;16:115–27.CrossRefGoogle Scholar
  20. 20.
    Liang YB, Friedman DS, Wong TY, et al. Prevalence and causes of low vision and blindness in a rural Chinese adult population: the Handan Eye Study. Ophthalmology. 2008;115:1965–72.CrossRefGoogle Scholar
  21. 21.
    Wang FH, Liang YB, Zhang F, et al. Prevalence of diabetic retinopathy in rural China: the Handan Eye Study. Ophthalmology. 2009;116:461–7.CrossRefGoogle Scholar
  22. 22.
    Peng XY, Wang FH, Liang YB, et al. Retinopathy in persons without diabetes: the Handan Eye Study. Ophthalmology. 2010;117:531–7, 537e531–2.CrossRefGoogle Scholar
  23. 23.
    Wang NL, Friedman DS, Zhou Q, et al. A population-based assessment of 24-hour intraocular pressure among subjects with primary open-angle glaucoma: the Handan eye study. Invest Ophthalmol Vis Sci. 2011;52:7817–21.CrossRefGoogle Scholar
  24. 24.
    Zhang Q, Li S, Liang Y, Wang F, Chen W, Wang N. Characteristics of optic disc parameters and its association in normal Chinese population: the Handan Eye Study. Chin Med J (Engl). 2014;127:1702–9.Google Scholar
  25. 25.
    Liang Y, Friedman DS, Zhou Q, et al. Prevalence and characteristics of primary angle-closure diseases in a rural adult Chinese population: the Handan Eye Study. Invest Ophthalmol Vis Sci. 2011;52:8672–9.CrossRefGoogle Scholar
  26. 26.
    Liang YB, Friedman DS, Zhou Q, et al. Prevalence of primary open angle glaucoma in a rural adult Chinese population: the Handan eye study. Invest Ophthalmol Vis Sci. 2011;52:8250–7.CrossRefGoogle Scholar
  27. 27.
    Foster PJ, Buhrmann R, Quigley HA, Johnson GJ. The definition and classification of glaucoma in prevalence surveys. Br J Ophthalmol. 2002;86:238–42.CrossRefGoogle Scholar
  28. 28.
    Jonas JB, Wang N, Wang YX, et al. Subfoveal choroidal thickness and cerebrospinal fluid pressure: the Beijing Eye Study 2011. Invest Ophthalmol Vis Sci. 2014;55:1292–8.CrossRefGoogle Scholar
  29. 29.
    Jonas JB, Wang N, Wang YX, You QS, Yang D, Xu L. Ocular Hypertension: General characteristics and estimated cerebrospinal fluid pressure. The Beijing Eye Study 2011. PLoS One. 2014;9(7):e100533.CrossRefGoogle Scholar
  30. 30.
    Xie X, Zhang X, Fu J, et al. Noninvasive intracranial pressure estimation by orbital subarachnoid space measurement: the Beijing Intracranial and Intraocular Pressure (iCOP) study. Crit Care. 2013;17:R162.CrossRefGoogle Scholar
  31. 31.
    Yang K, Zhan SY, Liang YB, et al. Association of dilated retinal arteriolar caliber with early age-related macular degeneration: the Handan Eye Study. Graefes Arch Clin Exp Ophthalmol. 2012;250:741–9.CrossRefGoogle Scholar
  32. 32.
    Jonas JB, Xu L, Zhang L, Wang Y, Wang Y. Optic disk size in chronic glaucoma: the Beijing eye study. Am J Ophthalmol. 2006;142:168–70.CrossRefGoogle Scholar
  33. 33.
    Pattanayak CW, Rubin DB, Zell ER. Propensity score methods for creating covariate balance in observational studies. Rev Esp Cardiol. 2011;64:897–903.CrossRefGoogle Scholar
  34. 34.
    Hall JK, Andrews AP, Walker R, Piltz-Seymour JR. Association of retinal vessel caliber and visual field defects in glaucoma. Am J Ophthalmol. 2001;132:855–9.CrossRefGoogle Scholar
  35. 35.
    Rankin SJ, Drance SM. Peripapillary focal retinal arteriolar narrowing in open angle glaucoma. J Glaucoma. 1996;5:22–8.PubMedGoogle Scholar
  36. 36.
    Cheung N, Wong TY. Obesity and eye diseases. Surv Ophthalmol. 2007;52:180–95.CrossRefGoogle Scholar
  37. 37.
    Xu L, Wang YX, Wang S, Jonas JB. Neuroretinal rim area and body mass index. PLoS One. 2012;7:e30104.CrossRefGoogle Scholar
  38. 38.
    Berdahl JP, Allingham RR, Johnson DH. Cerebrospinal fluid pressure is decreased in primary open-angle glaucoma. Ophthalmology. 2008;115:763–8.CrossRefGoogle Scholar
  39. 39.
    Berdahl JP, Fautsch MP, Stinnett SS, Allingham RR. Intracranial pressure in primary open angle glaucoma, normal tension glaucoma, and ocular hypertension: a case-control study. Invest Ophthalmol Vis Sci. 2008;49:5412–8.CrossRefGoogle Scholar
  40. 40.
    Berdahl JP, Fleischman D, Zaydlarova J, Stinnett S, Allingham RR, Fautsch MP. Body mass index has a linear relationship with cerebrospinal fluid pressure. Invest Ophthalmol Vis Sci. 2012;53:1422–7.CrossRefGoogle Scholar
  41. 41.
    Zhang Q, Jan C, Guo CY, et al. Association of intraocular pressure-related factors and retinal vessel diameter with optic disc rim area in subjects with and without primary open angle glaucoma. Clin Experiment Ophthalmol. 2018;46(4):389–99.CrossRefGoogle Scholar

Copyright information

© Springer Nature Singapore Pte Ltd. 2019

Authors and Affiliations

  • Qing Zhang
    • 1
    • 2
  • Chen Xin
    • 1
    • 2
  • Chunyu Guo
    • 3
  • Ye Zhang
    • 1
    • 2
  • Ningli Wang
    • 1
    • 2
    Email author
  1. 1.Beijing Institute of Ophthalmology, Beijing Tongren Eye Center, Beijing Tongren HospitalCapital Medical UniversityBeijingChina
  2. 2.Beijing Ophthalmology & Visual Sciences Key LaboratoryBeijingChina
  3. 3.Department of EpidemiologySchool of Public Health, University of MichiganAnn ArborUSA

Personalised recommendations