Intracranial Hypotension and Coexistent Normal-Pressure Glaucoma: 5-Year Follow-Up

  • Zhen Li
  • Ningli WangEmail author
Part of the Advances in Visual Science and Eye Diseases book series (AVSED, volume 1)


Trans-lamina pressure difference theory is a new theory on pathogenesis of glaucoma. The core of this theory is that it is the trans-lamina pressure difference that causes the change of lamina cribrosa, and the latter leads to the onset of glaucoma.


  1. 1.
    Quigley HA, Addicks EM, Green WR, et al. Optic nerve damage in human glaucoma. II. The site of injury and susceptibility to damage[J]. Arch Ophthalmol. 1981;99(4):635–49.CrossRefGoogle Scholar
  2. 2.
    Volkov VV. [Essential element of the glaucomatous process neglected in clinical practice][J]. Oftalmol Zh. 1976;31(7):500–4.PubMedGoogle Scholar
  3. 3.
    Yablonski M, Ritch R, Pokorny KS. Effect of decreased intracranial pressure on optic disc. Invest Ophthalmol Vis Sci. 1979;18((Suppl)):165.Google Scholar
  4. 4.
    Berdahl JP, Allingham RR, Johnson DH. Cerebrospinal fluid pressure is decreased in primary open-angle Glaucoma[J]. Ophthalmology. 2008;115(5):763–8.CrossRefGoogle Scholar
  5. 5.
    Ren R, Jonas JB, Tian G, et al. Cerebrospinal Fluid Pressure in Glaucoma[J]. Ophthalmology. 2010;117(2):259–66.CrossRefGoogle Scholar
  6. 6.
    Yang D, Fu J, Hou R, et al. Optic neuropathy induced by experimentally reduced cerebrospinal fluid pressure in monkeys[J]. Invest Ophthalmol Vis Sci. 2014;55(5):3067–73.CrossRefGoogle Scholar
  7. 7.
    Li Z, Yang DY, Lu Y, et al. Intracranial hypotension and co-existent normal-pressure glaucoma: the Beijing intracranial and intraocular pressure study[J]. Chin Med J (Engl). 2013;126(8):1588–9.Google Scholar

Copyright information

© Springer Nature Singapore Pte Ltd. 2019

Authors and Affiliations

  1. 1.Department of OphthalmologyXuanwu Hospital, Capital Medical UniversityBeijingChina
  2. 2.Beijing Institute of Ophthalmology, Beijing Tongren Eye Center, Beijing Tongren HospitalCapital Medical UniversityBeijingChina
  3. 3.Beijing Ophthalmology & Visual Sciences Key LaboratoryBeijingChina

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