Advertisement

Energy Theory of Glaucoma

  • Xiaoxia Li
  • Ningli WangEmail author
Chapter
Part of the Advances in Visual Science and Eye Diseases book series (AVSED, volume 1)

Abstract

Glaucoma is the leading cause of irreversible blindness [1], and it is a major public health issue. The pathological mechanism of glaucoma is not fully understood yet. In this chapter, we mainly focus on the glia cells which take part in the underlying mechanism of glaucoma.

References

  1. 1.
    Quigley HA, Broman AT. The number of people with glaucoma worldwide in 2010 and 2020. Br J Ophthalmol. 2006;90:262–7.CrossRefGoogle Scholar
  2. 2.
    Herculano-Houzel S. The glia/neuron ratio: how it varies uniformly across brain structures and species and what that means for brain physiology and evolution. Glia. 2014;62:1377–91.CrossRefGoogle Scholar
  3. 3.
    Khakh BS, Sofroniew MV. Diversity of astrocyte functions and phenotypes in neural circuits. Nat Neurosci. 2015;18:942–52.CrossRefGoogle Scholar
  4. 4.
    Davis CH, Kim KY, Bushong EA, et al. Transcellular degradation of axonal mitochondria. Proc Natl Acad Sci U S A. 2014;111:9633–8.CrossRefGoogle Scholar
  5. 5.
    Davis CH, Marsh-Armstrong N. Discovery and implications of transcellular mitophagy. Autophagy. 2014;10:2383–4.CrossRefGoogle Scholar
  6. 6.
    Hayakawa K, Esposito E, Wang X, et al. Transfer of mitochondria from astrocytes to neurons after stroke. Nature. 2016;535:551–5.CrossRefGoogle Scholar
  7. 7.
    Nagelhus EA, Veruki ML, Torp R, et al. Aquaporin-4 water channel protein in the rat retina and optic nerve: polarized expression in Muller cells and fibrous astrocytes. J Neurosci. 1998;18:2506–19.CrossRefGoogle Scholar
  8. 8.
    Li Y, Li D, Ying X, et al. An energy theory of glaucoma. Glia. 2015;63(9):1537–52.CrossRefGoogle Scholar
  9. 9.
    Dai C, Khaw PT, Yin ZQ, Li D, Raisman G, Li Y. Olfactory ensheathing cells rescue optic nerve fibers in a rat glaucoma model. Transl Vis Sci Technol. 2012;1:3.CrossRefGoogle Scholar
  10. 10.
    Islam MN, Das SR, Emin MT, et al. Mitochondrial transfer from bone-marrow-derived stromal cells to pulmonary alveoli protects against acute lung injury. Nat Med. 2012;18:759–65.CrossRefGoogle Scholar
  11. 11.
    Spees JL, Lee RH, Gregory CA. Mechanisms of mesenchymal stem/stromal cell function. Stem Cell Res Ther. 2016;7:125.CrossRefGoogle Scholar

Copyright information

© Springer Nature Singapore Pte Ltd. 2019

Authors and Affiliations

  1. 1.Beijing Institute of Ophthalmology, Beijing Tongren Eye CenterBeijing Tongren Hosptial, Capital Medical UniversityBeijingChina
  2. 2.Beijing Ophthalmology & Visual Sciences Key LaboratoryBeijingChina

Personalised recommendations