Neuroimaging Studies of Primary Dysmenorrhea

  • Intan Low
  • Shyh-Yuh Wei
  • Pin-Shiuan Lee
  • Wei-Chi Li
  • Lin-Chien Lee
  • Jen-Chuen HsiehEmail author
  • Li-Fen Chen
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 1099)


Primary dysmenorrhea (PDM), cyclic menstrual pain in the absence of pelvic anomalies, is one of the most common gynecological disorders in reproductive females. Classified as chronic pelvic pain syndrome, PDM encompasses recurrent spontaneous painful (“on”) and pain-free (“off”) states and is thus a good clinical model to study state- and trait-related changes of pain in the brain. In this chapter, we summarize state-of-the-art neuroimaging studies of primary dysmenorrhea from phenotype and endophenotype to genotype facets. Structural and functional brain alterations associated with primary dysmenorrhea are discussed.


Primary dysmenorrhea Chronic pelvic pain Neuroplasticity Resting-state Descending pain modulatory system Genetic polymorphism 



These studies and our laboratories were financially supported by the Ministry of Science Technology, Ministry of Education, National Yang-Ming University, Taipei Veterans General Hospital, and the Joint research program between Taipei Veterans General Hospital and National Taiwan University Hospital. We thank Dr. Hsiang-Tai Chao for performing the clinical assessment and Dr. Ming-Wei Lin for performing the genotyping of these studies. All participants are thanked for their support and contribution to these studies.


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Copyright information

© Springer Nature Singapore Pte Ltd. 2018

Authors and Affiliations

  • Intan Low
    • 1
    • 2
  • Shyh-Yuh Wei
    • 1
  • Pin-Shiuan Lee
    • 3
  • Wei-Chi Li
    • 1
  • Lin-Chien Lee
    • 1
  • Jen-Chuen Hsieh
    • 1
    • 2
    • 4
    Email author
  • Li-Fen Chen
    • 1
    • 2
    • 3
    • 4
  1. 1.Institute of Brain ScienceNational Yang-Ming UniversityTaipeiTaiwan
  2. 2.Integrated Brain Research Unit, Department of Medical ResearchTaipei Veterans General HospitalTaipeiTaiwan
  3. 3.Institute of Biomedical InformaticsNational Yang-Ming UniversityTaipeiTaiwan
  4. 4.Brain Research CenterNational Yang-Ming UniversityTaipeiTaiwan

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