Cortical LTP: A Synaptic Model for Chronic Pain

  • Min ZhuoEmail author
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 1099)


Cumulative evidence indicates that cortical synapses not only play important roles in pain perception and related emotional functions but also undergo long-term potentiation (LTP) and contribute to chronic pain. LTP is found at two key cortical regions such as the anterior cingulate cortex (ACC) and insular cortex (IC), and inhibition of cortical LTP produces analgesic effects as well as anxiolytic effects. In this chapter, I will summarize our work on ACC and IC and provide evidence for calcium-stimulated AC1 as a key molecule for cortical LTP and chronic pain.


Anterior cingulate cortex Insular cortex Long-term potentiation NMDA AC1 



I would like to thank Melissa Lepp for the help of the citation and reading of the manuscript. This work was supported by grants from the EJLB-CIHR Michael Smith Chair in Neurosciences and Mental Health, Canada Research Chair, Canadian Institute for Health Research operating grants (CIHR66975, 84256) and project grant (PJT-148648), Azrieli Neurodevelopmental Research Program, and Brain Canada (MZ).


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© Springer Nature Singapore Pte Ltd. 2018

Authors and Affiliations

  1. 1.Department of Physiology, Faculty of Medicine, Centre for the Study of PainUniversity of Toronto, Medical Sciences BuildingTorontoCanada

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