Knowing the Neuronal Mechanism of Spontaneous Pain to Treat Chronic Pain in the Future

  • Xiang-Yao LiEmail author
  • Jing-Hua Wang
  • Cheng Wu
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 1099)


Spontaneous pain is the major complain for the patients to see a doctor. Human imaging studies presented that spontaneous pain is mainly associated with activity changes in medial pain pathway, while broader brain regions were activated by allodynia pain. On behavioral level, temporally disassociation between the evoked pain and spontaneous pain was observed; these data gave a hint that the spontaneous pain and evoked pain may be mediated by different neuronal mechanisms. And more attentions should be paid to the spontaneous pain to treat the chronic pain in the future.


Neuropathic pain Spontaneous pain Evoked pain Central sensitization 



This study was supported by the National Program on Key Basic Research Project (973 Program) (2014CB548200) and Chinese National Natural Science Foundation (81571068).


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© Springer Nature Singapore Pte Ltd. 2018

Authors and Affiliations

  1. 1.Institute of Neuroscience, Key Laboratory of Medical Neurobiology of the Ministry of Health of China, School of MedicineZhejiang UniversityHangzhouChina

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