Sirtuin Modulators and Brain Aging

  • Hale Z. Toklu
  • Almari GinoryEmail author


The sirtuins are proteins with enzymatic activity, which regulate diverse cellular processes including aging, longevity, inflammation, obesity, and stress resistance. There are seven sirtuins in mammals with varied subcellular localization and enzymatic activity. Of these, SIRT1 exhibits NAD-dependent deacetylase activity, and it has been the most studied isoform to target aging-related neurodegenerative disorders and longevity due to caloric restriction. SIRT activation can exert positive effects in aging-related disorders such as metabolic, cardiovascular, and neurodegenerative diseases; while SIRT1 inhibitors have anticancer properties. Currently, a number of clinical trials are conveyed with modulators of SIRT. This chapter focuses on SIRT activators and their effects on brain aging.


Sirtuin SIRT1 Brain Aging Senescence SIRT activators, SIRT inhibitors, central nervous system 



Amyotrophic lateral sclerosis


Forkhead box O


Mammalian target of rapamycin


Nicotinamide adenine dinucleotide




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© Springer Nature Singapore Pte Ltd. 2018

Authors and Affiliations

  1. 1.Department of Clinical SciencesUniversity of Central Florida College of MedicineOrlandoUSA
  2. 2.HCA North Florida DivisionGraduate Medical EducationGainesvilleUSA
  3. 3.Graduate Medical EducationNorth Florida Regional Medical CenterGainesvilleUSA

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