The Place of Geroprotective Agents in Life Quality and Longevity of Companion Animals

  • Alev Akdoğan Kaymaz


Aging is a series of progressive degenerative body changes associated with decreased physiological functionality and a decline in the ability to adapt to metabolic stress. Geroscience particularly focuses on understanding the mechanisms of aging and multiple genetic and pharmacological therapies which have been developed in order to modulate the pace of natural aging and to prevent the age-related disorders such as cancer, kidney diseases, cardiovascular disorders, and many others; these geroprotective and senolytic interventions have shown to be beneficial for extending the life span and delaying age-related functional declines in rodents. Recent developments in geroscience also contributed to the improvement of quality of life and the extension of expected life span of cats and dogs. Like in humans, the life expectancy of cats and dogs varies significantly based on racial disparities; breed is an important determinant of life expectancy in pets. Other factors such as gender, genetics, environment, and stressors also play an important role throughout the aging process. Use of geroprotective agents by veterinarians is becoming more common day by day, extending the life span of pets and contributing to the establishment of a more peaceful home environment by decreasing the disease burden. This chapter will focus on the use of these geroprotective and senolytic agents and their overall impact on the prevention of age-related degenerative changes and disorders in companion animals: cats and dogs.


Aging Geroscience Longevity Life span Quality of life Cat Dog 


  1. Adams B, Chan A, Callahan H et al (2000) The canine as a model of human cognitive aging: recent developments. Prog Neuro-Psychopharmacol Biol Psychiatry 24:675–692CrossRefGoogle Scholar
  2. Ademowo OS, Dias HKI, Burton DGA et al (2017) Lipid (per) oxidation in dogs in Sweden from 1995 to 2002. Prev Vet Med 69(1–2):109–127Google Scholar
  3. Akdogan Kaymaz A, Ulgen S, Yanar K et al (2014) Oxidant status according to azotemia levels in cats. In: Proceedings 39th WSAVA CongresGoogle Scholar
  4. Albert RE, Benjamin SA, Shukla R (1994) Life span and cancer mortality in the beagle dog and humans. Mech Ageing Dev 74:149–159CrossRefGoogle Scholar
  5. Boyd LM, Langston C, Thompson K et al (2008) Survival in cats with naturally occurring chronic kidney disease (2000–2002). J Vet Intern Med 22:1111–1117CrossRefGoogle Scholar
  6. Bybee SN, Scorza AV, Lappin MR (2011) Effect of the probiotic Enterococcus faecium SF68 on presence of diarrhea in cats and dogs housed in an animal shelter. J Vet Intern Med 25:856–860CrossRefGoogle Scholar
  7. Cakatay U, Kayalı R (2005) Plasma protein oxidation in aging rats after alpha-lipoic acid administration. Biogerontology 6(2):87–93CrossRefGoogle Scholar
  8. Castillo-Quan JI, Blackwell TK (2016) Metformin: restraining nucleocytoplasmic shuttling to fight cancer and aging. Cell 167(7):1670–1671CrossRefGoogle Scholar
  9. Chapagain D, Range F, Huber L et al (2017) Cognitive aging in dogs. Gerontology. CrossRefGoogle Scholar
  10. Chase K, Jones P, Martin A et al (2009) Genetic mapping of fixed phenotypes: disease frequency as a breed. J Hered 100(Supplement 1):37–41CrossRefGoogle Scholar
  11. Chastain CB (2004) The endocrine and metabolic system. In: Hoskins JD (ed) Geriatrics & gerontology of dog and cat. Saunders, St. Louis, pp 271–302CrossRefGoogle Scholar
  12. Chew BP, Park JS (2004) Carotenoid action on the immune response. J Nutr 134(1):257S–261SCrossRefGoogle Scholar
  13. Chung HY, Cesari M, Anton S et al (2009) Molecular inflammation: underpinnings of aging and age-related diseases. Ageing Res Rev 8:18–30CrossRefGoogle Scholar
  14. Comfort A (1956) Maximum ages reached by domestic cats. J Mammal 37(1):118CrossRefGoogle Scholar
  15. Comfort A (1960) Longevity and mortality in dogs of four breeds. J Gerontol 15(2):126–129CrossRefGoogle Scholar
  16. Courcier E, Thomson R, Mellor D, et al (2009) Canine obesity: do owners see what you see? In: Proceedings. Br Sm Anim Vet CongGoogle Scholar
  17. Cozzi B, Ballarin C, Mantovani R, Rota A (2017) Aging and veterinary care of cats, dogs, and horses through the records of three university veterinary hospitals. Front Vet Sci 4:14Google Scholar
  18. Davies M (2012) Geriatric screening in first opinion practice-results from 45 dogs. J Small Anim Pract 53:507–513CrossRefGoogle Scholar
  19. Davis PR, Head E (2014) Prevention approaches in a preclinical canine model of Alzheimer’s disease: benefits and challenges. Front Pharmacol 5:47CrossRefGoogle Scholar
  20. Di Cerbo A, Morales-Medina JC, Palmieri B et al (2017) Functional foods in pet nutrition: focus on dogs and cats. Res Vet Sci 112:161–166CrossRefGoogle Scholar
  21. DiBartola SP, Broome MR, Stein BS et al (1996) Effect of treatment of hyperthyroidism on renal function in cats. JAVMA 208(6):875–878PubMedGoogle Scholar
  22. Diez M, Nguyen P (2006) The epidemiology of canine and feline obesity. Waltham Focus 16:2–8Google Scholar
  23. Dobson JM, Samuel S, Milstein H et al (2002) Canine neoplasia in the UK: estimates of incidence rates from a population of insured dogs. JSAP 43(6):240–246Google Scholar
  24. Dzanis DA (2004) Nutritional requirements and dietary management. In: Hoskins JD (ed) Geriatrics & gerontology of dog and cat. Saunders, St. Louis, pp 18–28Google Scholar
  25. Edney ATB, Smith PM (1986) Study of obesity in dogs visiting veterinary practices in the United Kingdom. Vet Rec 118:391–396CrossRefGoogle Scholar
  26. Eichelberg H, Seine R (1996) Life expectancy and cause of death in dogs. I. The situation in mixed breeds and various dog breeds. Berl Munch Tierarztl 109:292–303Google Scholar
  27. Egenvall A, Bonnett BN, Öhagena P et al (2005) Incidence of and survival after mammary tumors in a population of over 80,000 insured female dogs in Sweden from 1995 to 2002. Prev Vet Med 69(1–2):109–127CrossRefGoogle Scholar
  28. Egenvall A, Nodvedt A, Haggstrom J et al (2009) Mortality of life-insured Swedish cats during 1999–2006: age, breed, sex, and diagnosis. J Vet Intern Med 23:1175–1183CrossRefGoogle Scholar
  29. Fahnestock M, Marchese M, Head E et al (2012) BDNF increases with behavioral enrichment and an antioxidant diet in the aged dog. Neurobiol Aging 33(3):546–554CrossRefGoogle Scholar
  30. Fleming JM, Creevy KE, Promislow DEL (2011) Mortality in North American dogs from 1984 to 2004: an investigation into age-, size-, and breed-related causes of death. J Vet Intern Med 25(2):187–198CrossRefGoogle Scholar
  31. Fortney WD (2004) Geriatrics and aging. In: Hoskins JD (ed) Geriatrics & gerontology of dog and cat. Saunders, St. Louis, pp 1–4Google Scholar
  32. Freeman LM (2012) Cachexia and sarcopenia: emerging syndromes of importance in dogs and cats. J Vet Intern Med 26:3–17CrossRefGoogle Scholar
  33. German AJ (2006) The growing problem of obesity in dogs and cats. J Nutr 136:1940S–1946SCrossRefGoogle Scholar
  34. German AJ (2015) Style over substance: what can parenting styles tell us about ownership styles and obesity in companion animals? Br J Nutr 113:S72–S77CrossRefGoogle Scholar
  35. Godfrey DR (2005) Osteoarthritis in cats: a retrospective radiological study. JSAP 46(9):425–429Google Scholar
  36. Golini L, Colangeli R, Tranquillo V et al (2009) Association between neurologic and cognitive dysfunction signs in a sample of aging dogs. J Vet Behavior 4(1):25–30CrossRefGoogle Scholar
  37. Gossellin J, Wren JA, Sunderland SL (2007) Canine obesity: an overview. J Vet Pharmacol Ther 30(Suppl 1):1–10CrossRefGoogle Scholar
  38. Grant RW, Vester Boler BM, Ridge TK et al (2011) Adipose tissue transcriptome changes during obesity development in female dogs. Physiol Genomics 43(6):295–307CrossRefGoogle Scholar
  39. Greer KA, Canterberry SC, Murphy KE (2007) Statistical analysis regarding the effects of height and weight on life span of the domestic dog. Res Vet Sci 82(2):208–214CrossRefGoogle Scholar
  40. Greer KA, Hughes LM, Masternak MM (2011) Connecting serum IGF-1, body size, and age in the domestic dog. Age 33(3):475–483CrossRefGoogle Scholar
  41. Grimm D (2015) Why we outlive our pets. Science 350(6265):1182–1185CrossRefGoogle Scholar
  42. Gunn-Moore D, Moffat K, Christie EA et al (2007) Cognitive dysfunction and the neurobiology of ageing in cats. JSAP 48:546–553Google Scholar
  43. Head E (2013) A canine model of human aging and Alzheimer’s disease. Biochim Biophys Acta (BBA) – Mol Basis Dis 1832(9):1384–1389CrossRefGoogle Scholar
  44. Head E, Nukala VN, Fenoglio KA et al (2009) Effects of age, dietary, and behavioral enrichment on brain mitochondria in a canine model of human aging. Exp Neurol 220(1):171–176CrossRefGoogle Scholar
  45. Henegar JR, Bigler SA, Henegar LK et al (2001) Functional and structural changes in the kidney in the early stages of obesity. J Am Soc Nephrol 12:1211–1217PubMedGoogle Scholar
  46. Herstad HK, Nesheim BB, L’ Abée-Lund T et al (2010) Effects of a probiotic intervention in acute canine gastroenteritis – a controlled clinical trial. J Small Anim Pract 51:34–38CrossRefGoogle Scholar
  47. Hesta M, Ottermans C, Krammer-Lukas S et al (2006) The effect of vitamin C supplementation in healthy dogs on antioxidative capacity and immune parameters. J Anim Physiol Anim Nutr 93(2009):26–34Google Scholar
  48. Heuberger R, Wakshlag J (2011) The relationship of feeding patterns and obesity in dogs. J Anim Physiol Anim Nutr (Berl) 95(1):98–105CrossRefGoogle Scholar
  49. Hideki H, Yoshiro O, Masuo O, Kazuo F (1988) Epidemiological studies on the expectation of life for dogs computed from animal cemetery records. Jpn J Vet Sci 50(5):1003–1008Google Scholar
  50. Hoenig M (2014) Comparative aspects of human, canine, and feline obesity and factors predicting progression to diabetes. Vet Sci 1:121–135CrossRefGoogle Scholar
  51. Hoenig M, Wilkins C, Holson JC et al (2003) Effects of obesity on lipid profiles in neutered male and female cats. Am J Ver Res 64(3):299–303CrossRefGoogle Scholar
  52. Houpt KA, Beaver B (1981) Behavioral problems of geriatric dogs and cats. Vet Clin North Am Small Anim Pract 11(4):643–652CrossRefGoogle Scholar
  53. Jaso-Friedmann L, Leary JH, Praveen K et al (2008) The effects of obesity and fatty acids on the feline immune system. Vet Immunol Immunopathol 122(1–2):146–152CrossRefGoogle Scholar
  54. Kaeberlein M, Creevy KE, Promislow DEL (2016) The Dog Aging Project: translational geroscience in companion animals. Mamm Genome 27:279–288CrossRefGoogle Scholar
  55. Kelley RL, Minikhiem D, Kiely B et al (2009) Clinical benefits of probiotic canine-derived Bifidobacterium animalis strain AHC7 in dogs with acute idiopathic diarrhea. Vet Ther 10:121–130PubMedGoogle Scholar
  56. Kim HW, Chew BP, Wong TS et al (2000) Modulation of humoral and cell-mediated immune responses by dietary lutein in cats. Vet Immunol Immunopathol 73(3–4):331–341CrossRefGoogle Scholar
  57. Kirkland JL (2013) Inflammation and cellular senescence: potential contribution to chronic diseases and disabilities with aging. Public Policy Aging Report 23(4):12–15CrossRefGoogle Scholar
  58. Laflamme DP (2005) Nutrition for aging cats and dogs and the importance of body condition. Vet Clin North Am Small Anim Pract 35(3):713–742CrossRefGoogle Scholar
  59. Laflamme DP (2012) Companion animals symposium: obesity in dogs and cats: what is wrong with being fat? JAS 90(5):1653–1662Google Scholar
  60. Landsberg GM, Araujo JA (2005) Behavior problems in geriatric pets. Vet Clin Small Anim 35:675–698CrossRefGoogle Scholar
  61. Landsberg GM, Malamed R (2017) Clinical picture of canine and feline cognitive impairment. In: Landsberg G, Maďari A, Žilka N (eds) Canine and feline dementia. Springer, ChamCrossRefGoogle Scholar
  62. Landsberg GM, Nichol J, Araujo JA (2012) Cognitive dysfunction syndrome: a disease of canine and feline brain aging. Small Anim Pract 42(4):749–768CrossRefGoogle Scholar
  63. Larson JC, Allstadt SD, Fan TM et al (2016) Pharmacokinetics of orally administered low-dose rapamycin in healthy dogs. AVMA 77(1):65–71Google Scholar
  64. Lascelles BD, Robertson SA (2010) DJD-associated pain in cats. What can we do to promote patient comfort? J Feline Med Surg 12(3):200–212CrossRefGoogle Scholar
  65. Lenox CE, Bauer JE (2013) Potential adverse effects of omega-3 fatty acids in dogs and cats. J Vet Intern Med 27(2):217–226CrossRefGoogle Scholar
  66. Li Y, Deeb B, Pendergrass W, Wolf N (1996) Cellular proliferative capacity and life span in small and large dogs. J Gerontol Ser A Biol Med Sci 51A(6):B403–B408CrossRefGoogle Scholar
  67. Lopez-Otin et al (2013) The hallmarks of aging. Cell 2013 Jun 6 153(6):1194–1217. CrossRefPubMedPubMedCentralGoogle Scholar
  68. Manteca X (2011) Nutrition and behavior in senior dogs. Top Companion Anim Med 26(1):33–36CrossRefGoogle Scholar
  69. Merlo DF, Rossi L, Pellegrino C et al (2008) Cancer incidence in pet dogs: findings of the animal tumor registry of Genoa, Italy. J Vet Intern Med 22:976–984CrossRefGoogle Scholar
  70. Michell AR (1999) Longevit of British breeds of dog and its relationships with-sex, size, cardiovascular variables and disease. Vet Rec 145(22):625–629CrossRefGoogle Scholar
  71. Miller MS, Tilley LP, Smith FW Jr (1989) Cardiopulmonary disease in the geriatric dog and cat. Vet Clin North Am Small Anim Pract 19(1):87–102CrossRefGoogle Scholar
  72. Montoya-Alonso JA, Bautista-Castaño I, Peña C (2017) Prevalence of canine obesity, obesity-related metabolic dysfunction, and relationship with owner obesity in an obesogenic region of Spain. Front Vet Sci 4:59. CrossRefPubMedPubMedCentralGoogle Scholar
  73. Muir WW, Wiese AJ, ThomasBS et al (2004) Prevalence and characteristics of pain in dogs and cats examined as outpatients at a veterinary teaching hospital. JAVMA 224(9):1459–1463CrossRefGoogle Scholar
  74. Murphy M, Lusby AL, Bartges JW et al (2011) Size of food bowl and scoop affects amount of food owners feed their dogs. J Anim Physiol Anim Nutr (Berl) 96(2):237–241CrossRefGoogle Scholar
  75. Neiger R (2004) In: Hoskins JD (ed) Geriatrics and gerontology of the dog and cat. Saunders, St. LouisGoogle Scholar
  76. Nelson RW, Reusch CE (2014) Anımal models of disease: classification and etiology of diabetes in dogs and cats. J Endocrinol 222:1–9CrossRefGoogle Scholar
  77. Nolan J, Loskutovaa E, Howardb AN et al (2014) Macular pigment, visual function, and macular disease among subjects with Alzheimer’s disease: an exploratory study. J Alzheimer Dis 42:1191–1202CrossRefGoogle Scholar
  78. O’Neill DG (2016) Epidemiology of diabetes mellitus among 193,435 cats attending primary-care veterinary practices in England. J Vet Intern Med 30:964–972CrossRefGoogle Scholar
  79. O’Neill DG, Church DB, McGreevy PD et al (2013) Longevity and mortality of owned dogs in England. Vet J 198:638–643CrossRefGoogle Scholar
  80. O’Neill GD, Church DB, McGreevy PD et al (2015) Longevity and mortality of cats attending primary care veterinary practices in England. J Feline Med Surg 17:125–133CrossRefGoogle Scholar
  81. Osto M, Lutz TA (2015) Translational value of animal models of obesity—focus on dogs and cats. Eu J Pharmacol 759:240–252CrossRefGoogle Scholar
  82. Patronek GJ, Waters DJ, Glickman LT (1997) Comparative longevity of pet dogs and humans: implications for gerontology research. J Gerontol Ser A Biol Med Sci 52A(3):B171–B178CrossRefGoogle Scholar
  83. Pitt JN, Kaeberlein M (2015) Why is aging conserved and what can we do about it? PLoS Biol 13(5):e1002176CrossRefGoogle Scholar
  84. Proschowsky HF, Rugbjerg H, Ersbøll AK (2003) Mortality of purebred and mixed-breed dogs in Denmark. Prev Vet Med 58(1-2):63–74CrossRefGoogle Scholar
  85. Quimby JM, Maranon DG, Battaglia CLR et al (2013) Feline chronic kidney disease is associated with shortened telomeres and increased cellular senescence. Am J Physiol Renal Physiol 305(3):F295–F303CrossRefGoogle Scholar
  86. Radin MJ, Sharkey LC, Holycross J (2009) Adipokines: a review of biological and analytical principles and an update in dogs, cats, and horses. Vet Clin Pathol 38(2):136–156CrossRefGoogle Scholar
  87. Raffan E (2013) The big problem: battling companion animal obesity. Vet Rec 173:287–291CrossRefGoogle Scholar
  88. Reynolds CA, Oyama MA, Rush JE et al (2010) Perceptions of quality of life and priorities of owners of cats with heart disease. J Vet Med 24:1421–1426Google Scholar
  89. Slingerland LI, Fazilova VV, Plantinga EA et al (2009) Indoor confinement and physical inactivity rather than the proportion of dry food are risk factors in the development of feline type 2 diabetes mellitus. Vet J 179:247–253CrossRefGoogle Scholar
  90. Snigdha S, de Riverab C, Milgram NW et al (2015) Effect of mitochondrial cofactors and antioxidants supplementation on cognition in the aged canine. Neurobiol Aging 37:171–178CrossRefGoogle Scholar
  91. Spain CV, Scarlett JM, Houpt KA (2004) Long-term risks and benefits of early-age gonadectomy in dogs. JAVMA 224(3):380–387CrossRefGoogle Scholar
  92. Spector WS (1956) Handbook of biological data. Saunders, PhiladelphiaGoogle Scholar
  93. Strain GM (2017) Hearing disorders in cats. J Feline Med Surg 19(3):276–287CrossRefGoogle Scholar
  94. Sutter NB, Bustamente CD, Chase K et al (2007) A single IFF1 allele is a majör determinant of small size in dogs. Science 316:112–115CrossRefGoogle Scholar
  95. Tanner AE, Martin J, Saker KE (2007) Oxidative stress and ınflammatory state ınduced by obesity in the healthy feline. J Anim Physiol Anim Nutr (Berl) 91(3–4):163–166CrossRefGoogle Scholar
  96. Ulgen S, Bayrakal A, Sargın E et al (2014) The changing patterns in referral rates of geriatric cats and dogs to an university clinic. J Fac Vet Med Istanbul Univ 41(2):232–237Google Scholar
  97. Urfer SR, Kaeberlein TL, Mailheau S, Bergman PJ, Creevy KE, Promislow DEL, Kaeberlein M (2017) A randomized controlled trial to establish effects of short-term rapamycin treatment in 24 middle-aged companion dogs. GeroScience 39(2):117–127CrossRefGoogle Scholar
  98. van Hagen MA, Ducro BJ, van den Broek J et al (2005) Incidence, risk factors, and hereditability estimates of hind limb lameness caused by hip dysplasia in a birth cohort of boxers. Am J Vet Res 66:307–312CrossRefGoogle Scholar
  99. van Hoek I, Daminet S (2009) Interactions between thyroid and kidney function in pathological conditions of these organ systems: a review. Gen Comp Endocrinol 160(3):205–215CrossRefGoogle Scholar
  100. Weese JS, Arroyo L (2003) Bacteriological evaluation of dog and cat diets that claim to contain probiotics. Can Vet J 44(3):212–215PubMedPubMedCentralGoogle Scholar
  101. Williams TL, Peak KJ, Brodbelt D et al (2010) Survival and the development of azotemia after treatment of hyperthyroid cats. J Vet Intern Med 24(4):863–869CrossRefGoogle Scholar
  102. Williams TL, Elliott J, Syme HM (2014) Effect on renal function of restoration of euthyroidism in hyperthyroid cats with iatrogenic hypothyroidism. J Vet Intern Med 28(4):1251–1255CrossRefGoogle Scholar
  103. Williams D, Fitchie A, Colitz C (2015) An oral antioxidant formulation delaying and potentially reversing. Int J Diabetes Clin Res 2(1):1–5CrossRefGoogle Scholar
  104. Wonisch W, Falk A, Sundl I et al (2012) Oxidative stress increases continuously with BMI and age with unfavourable profiles in males. Aging Male 15(3):159–165. CrossRefPubMedGoogle Scholar
  105. Wren JA, King VL, Campbell SL et al (2007) Biologic activity of dirlotapide, a novel microsomal triglyceride transfer protein inhibitor, for weight loss in obese dogs. J Vet Pharmacol Ther 30(Suppl 1):33–42CrossRefGoogle Scholar
  106. Zoran D (2010) Obesity in dogs and cats; a metabolic and endocrine disorder. Vet Clin Small Anim 40:221–239CrossRefGoogle Scholar

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© Springer Nature Singapore Pte Ltd. 2018

Authors and Affiliations

  • Alev Akdoğan Kaymaz
    • 1
  1. 1.Department of Internal Medicine, Faculty of Veterinary MedicineIstanbul UniversityIstanbulTurkey

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