Activation of Plasma Membrane Redox System: A Novel Antiaging Strategy
The possibility to manipulate the aging process and extend healthy life has always fascinated humans. Scientific studies during the past few decades have dissected molecular mechanisms which play important roles in determining longevity. There is increasing evidence that the hypothesis based on structural and functional damage during aging involves a change in cellular redox states. Recent studies document that the plasma membrane redox system (PMRS) of eukaryotic cells acts as redox balancer by transferring reducing equivalents that are used to maintain homeostasis. As a compensatory mechanism, overexpression of PMRS has been noted during aging. It is hypothesized that activation of PMRS may provide a strategy to counteract redox shift and oxidative stress during aging. The present chapter deals with activation of PMRS and its role in antiaging intervention.
KeywordsAging Ascorbate Life span Oxidative stress PMRS
KBP gratefully acknowledges the continuous support and encouragement provided by Director, CSIR-CSMCRI, Bhavnagar.
Conflict of Interest
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