Role of Phytochemicals in Eliciting Longevity Genes
Phytochemicals are diverse secondary metabolites derived from plants, and it has been proven that phytochemicals can extend longevity by evolutionarily conserved mechanisms. The positive impact of dietary phytochemicals on overall health and longevity has been studied extensively over the past decade. The emerging role of phytochemicals as an effector of metabolic and longevity signals offers new therapeutic perspectives. In this regard, we will discuss the role of phytochemicals in eliciting the longevity genes and also the various mechanisms involved. This review will give a broad outline of how different phytochemicals modulate signaling pathways that modulate the expression of specific set of genes. This review will also highlight the most exciting perspective for research in the future in this rapidly developing field of signaling pathways which include the genes encoding heat shock protein, genes responsible for the antioxidant response, genes involved in metabolism, etc. and are crucial for the phytochemicals to elicit longevity.
Despite various beneficial biological functions, phytochemicals might have adverse side effects like carcinogenicity and genotoxicity at high doses or concentrations. Hence, the future research challenge is to determine the optimal dose range and to perform intervention studies in order to improve longevity.
KeywordsAging Phytochemicals Longevity Oxidative stress
- Baur JA, Pearson KJ, Price NL, Jamieson HA, Lerin C, Kalra A, Prabhu VV, Allard JS, Lopez-Lluch G, Lewis K, Pistell PJ, Poosala S, Becker KG, Boss O, Gwinn D, Wang M, Ramaswamy S, Fishbein KW, Spencer RG, Lakatta EG, Le Couteur D, Shaw RJ, Navas P, Puigserver P, Ingram DK, de Cabo R, Sinclair DA (2006) Resveratrol improves health and survival of mice on a high-calorie diet. Nature 444(7117):337–342CrossRefGoogle Scholar
- Franco-Enzástiga Ú, Santana-Martínez RA, Silva-Islas CA, Barrera-Oviedo D, Chánez-Cárdenas ME, Maldonado PD (2017) Chronic administration of S-allylcysteine activates Nrf2 factor and enhances the activity of antioxidant enzymes in the striatum, frontal cortex and hippocampus. Neurochem Res 42(11):3041–3051CrossRefGoogle Scholar
- Koropatnick TA, Kimbell J, Chen R, Grove JS, Donlon TA, Masaki KH, Rodriguez BL, Willcox BJ, Yano K, Curb JD (2008) A prospective study of high-density lipoprotein cholesterol, cholesteryl ester transfer protein gene variants, and healthy aging in very old Japanese-american men. J Gerontol A Biol Sci Med Sci 63(11):1235–1240CrossRefGoogle Scholar
- Krishnan TR, Velusamy P, Srinivasan A, Ganesan T, Mangaiah S, Narasimhan K, Chakrapani LN, J T, Walter CE, Durairajan S, Nathakattur Saravanabavan S, Periandavan K (2014) EGCG mediated downregulation of NF-AT and macrophage infiltration in experimental hepatic steatosis. Exp Gerontol 57:96–103CrossRefGoogle Scholar
- Longo VD, Antebi A, Bartke A, Barzilai N, Brown-Borg HM, Caruso C, Curiel TJ, de Cabo R, Franceschi C, Gems D, Ingram DK, Johnson TE, Kennedy BK, Kenyon C, Klein S, Kopchick JJ, Lepperdinger G, Madeo F, Mirisola MG, Mitchell JR, Passarino G, Rudolph KL, Sedivy JM, Shadel GS, Sinclair DA, Spindler SR, Suh Y, Vijg J, Vinciguerra M, Fontana L (2015) Interventions to slow aging in humans: are we ready? Aging Cell 14(4):497–510CrossRefGoogle Scholar
- Miller RA, Harrison DE, Astle CM, Fernandez E, Flurkey K, Han M, Javors MA, Li X, Nadon NL, Nelson JF, Pletcher S, Salmon AB, Sharp ZD, Van Roekel S, Winkleman L, Strong R (2014) Rapamycin-mediated lifespan increase in mice is dose and sex dependent and metabolically distinct from dietary restriction. Aging Cell 13(3):468–477CrossRefGoogle Scholar
- Morselli E, Maiuri MC, Markaki M, Megalou E, Pasparaki A, Palikaras K, Criollo A, Galluzzi L, Malik SA, Vitale I, Michaud M, Madeo F, Tavernarakis N, Kroemer G (2010) Caloric restriction and resveratrol promote longevity through the Sirtuin-1-dependent induction of autophagy. Cell Death Dis 1:e10CrossRefGoogle Scholar
- Pawlikowska L, Hu D, Huntsman S, Sung A, Chu C, Chen J, Joyner AH, Schork NJ, Hsueh WC, Reiner AP, Psaty BM, Atzmon G, Barzilai N, Cummings SR, Browner WS, Kwok PY, Ziv E, Study of Osteoporotic Fractures (2009) Association of common genetic variation in the insulin/IGF1 signaling pathway with human longevity. Aging Cell 8(4):460–472CrossRefGoogle Scholar
- Takahashi K, Ishigami A (2017) Anti-aging effects of coffee. Aging (Albany NY) 9(8):1863–1864Google Scholar
- West M, Mhatre M, Ceballos A, Floyd RA, Grammas P, Gabbita SP, Hamdheydari L, Mai T, Mou S, Pye QN, Stewart C, West S, Williamson KS, Zemlan F, Hensley K (2004) The arachidonic acid 5-lipoxygenase inhibitor nordihydroguaiaretic acid inhibits tumor necrosis factor alpha activation of microglia and extends survival of G93A-SOD1 transgenic mice. J Neurochem 91(1):133–143CrossRefGoogle Scholar
- Yang CS, Lee MJ, Chen L (1999) Human salivary tea catechin levels and catechin esterase activities: implication in human cancer prevention studies. Cancer Epidemiol Biomark Prev 8(1):83–89Google Scholar
- World Population Ageing-Highlights (2015) Department of Economic and Social Affairs, United Nations, New YorkGoogle Scholar