Epigenetic Changes in Aging and Modulation by Dietary Nutrients
Aging is a complex natural process, involving various factors exhibited by all living organisms. It is visible in a consistent deterioration of regular physiological functions in a time-dependent fashion. Various scientific studies in different model organisms indicate that epigenetic alterations play a huge role in the aging process. Such types of epigenetic change occur in the genes responsible for aging and also affect their function. These types of epigenetic changes occur at different levels that include DNA methylation, change in levels of the core histones, posttranslational modifications of histone and replacement of canonical histones with another form of histone, and altered noncoding RNA expression, during both individual’s aging and replicative senescence. Dietary nutrients can significantly affect the epigenetic medications. This chapter will discuss how these changes affect the functioning of the genes and are targeted by the dietary nutrients.
KeywordsAging Dietary nutrients DNA methylation Epigenetics Histone modifications ncRNA
I would like to thanks Dr. Abhishek Kumar Singh, Department of Biochemistry, Faculty of Science, University of Allahabad, Allahabad, for critical revision of the manuscript and valuable suggestion. I also wish to acknowledge Director, IIT-Bombay, Mumbai, for giving me an opportunity to work in the institute. The authors declare that they have no competing interests.