Advertisement

Pulmonary Emphysema

  • Yong Fan
  • Tian Jiang
Chapter

Abstract

Chronic obstructive pulmonary disease is the disease characterized with airflow limitation that is chronically progressive and irreversible. Its high disability and mortality rate has a tendency to increase year by year, leading to heavy social economic burden [1, 2]. As a result, the disease is treated as a public health issue worldwide. Chronic obstructive pulmonary emphysema is the most common clinical manifestation. In clinics, pulmonary emphysema manifests progressive and irreversible airflow limitation. Pathologically, pulmonary emphysema shows elasticity attenuation and overexpansion in distal airway of terminal bronchioles and damage in alveolar walls and bronchiolar walls with no obvious fibrosis. An investigation of 20,245 adults in 7 regions showed that 8.2% of the adults aged over 40 years old suffered from chronic obstructive pulmonary emphysema. As estimated by the Global Burden of Diseases Study, it will be the third leading cause of death worldwide in 2020. The data of the World Bank and the World Health Organization show that the disease will be the fifth weightiest economic burden all over the world in 2020 [3, 4].

References

  1. 1.
    Cooper JD, Patterson GS, Sundaresan RS, et al. Results of 150 consecutive bilateral lung volume reduction procedures in patients with severe emphysema. J Thorac Cardiovasc Surg. 1996;112:1319.CrossRefGoogle Scholar
  2. 2.
    Galluccio G, Lucantoni G. Bronchoscopic lung volume reduction for pulmonary emphysema: preliminary experience with a new NOV ATECH endobronchial silicone one-way valve. Interact Cardiovasc Thorac Surg. 2010;11:213–5.CrossRefGoogle Scholar
  3. 3.
    Lopez AD, Murray CC. The global burden of disease, 1990–2020. Nat Med. 1998;4:1241–3.CrossRefGoogle Scholar
  4. 4.
    Herth FJ, Gompelmann D, Bonnet R, et al. Treatment of advanced emphysema with emphysematous lung sealant (Aeriseal). Respiration. 2011;82(1):36–45.CrossRefGoogle Scholar
  5. 5.
    Kramer MR, Refaely Y, Maimon MN, et al. Bilateral endoscopic sealant lung volume reduction therapy for advanced emphysema. Chest. 2012;142(5):1111–7.CrossRefGoogle Scholar
  6. 6.
    Lausberg HF, Chino K, Patterson GA, et al. Bronchial fenestration improves expiratory flow in emphysematous human lungs. Ann Thorac Surg. 2003;75:393–7.CrossRefGoogle Scholar
  7. 7.
    Moore AJ, Cetti E, Haj-Yahia S, et al. Unilateral extrapulmonary airway bypass in advanced emphysema. Ann Thorac Surg. 2010;89(3):899–906.CrossRefGoogle Scholar
  8. 8.
    Rendina EA, De Giacomo T, Venuta F, et al. Feasibility and safety of the airway bypass procedure for patients with emphysema. J Thorac Cardiovasc Surg. 2003;125:1294–9.CrossRefGoogle Scholar
  9. 9.
    Sciurba FC, Ernst A, Herth F J, et al. A randomized study of endobronchial valves for advanced emphysema. N Engl J Med. 2010;363(13):1233–44.CrossRefGoogle Scholar
  10. 10.
    Shah P, Slebos DJ, Cardoso PFG, et al. Bronchoscopic lung volume reduction with exhale airway stents for emphysema (EASE trial): randomised, sham-controlled, multicentre trial. Lancet. 2011;378:997–1005.CrossRefGoogle Scholar
  11. 11.
    Slebos DJ, Klooster K, Ernst A, et al. Bronchoscopic lung volume reduction coil treatment of patients with severe heterogeneous emphysema. Chest. 2012;142(3):574–82.CrossRefGoogle Scholar
  12. 12.
    Snell G, Herth F, Hopkins P, et al. Bronchoscopic thermal vapor ablation therapy in the management of heterogeneous emphysema. Eur Respir J. 2012;39(6):1326–33.CrossRefGoogle Scholar
  13. 13.
    Takahashi S, Nakamura H, Seki M, et al. Reversal of elastase-induced pulmonary emphysema and promotion of alveolar epithelial cell proliferation by simvastatin in mice. Am J Physiol Lung Cell Mol Physiol. 2008;294:L882–90.CrossRefGoogle Scholar
  14. 14.
    Wan IY, Toma TP, Geddse DM, et al. Bronchoscopic lung volume reduction for end-stage emphysema, report on the first 98 patients. Chest. 2006;129:518–26.CrossRefGoogle Scholar

Copyright information

© Springer Nature Singapore Pte Ltd. 2019

Authors and Affiliations

  • Yong Fan
    • 1
  • Tian Jiang
    • 2
  1. 1.Department of RadiologyGeneral Hospital, Tianjin Medical UniversityTianjinChina
  2. 2.Department of Interventional RadiologyThe First Affiliated Hospital of Zhengzhou UniversityZhengzhouChina

Personalised recommendations