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HIV-AIDS: An Unconquered Immune War

  • S. K. Arora
  • Gurleen Mehta
Chapter

Abstract

Acquired immune deficiency syndrome (AIDS) is a disease that has shaken the world affecting millions of people from all corners of the society. Syndrome involves the compromised state of the host defense system which results in impaired immunity leading to increased susceptibility of the host to opportunistic infections or predisposition to malignancies. The disease progression is monitored by CD4 cell counts and plasma virus loads in the blood of the infected patients. The disease progression in HIV infection is dependent on many factors, but most importantly, the disease progression depends upon how the viral factors and host factors interact with each other. Opportunistic infections (OIs) lead to increased mortality in the patients, and tuberculosis accounts for the most common OI. Early detection, diagnosis and appropriate treatment of OIs can slow down disease progression. The antiretroviral treatment leads to decrease in the viral loads and increase in the CD4 T lymphocyte count in the infected individuals. Strict adherence to treatment can significantly improve the quality of life of the patients infected with HIV.

Keywords

AIDS – Acquired immune deficiency syndrome ART – Antiretroviral treatment CD – Cluster of differentiation HIV – Human immunodeficiency virus OI – Opportunistic infection 

References

  1. Alimonti JB, Blake Ball T, Fowke KR (2003) Mechanisms of CD4+ T lymphocyte cell death in human immunodeficiency virus infection and AIDS. J Gen Virol 84:1649–1661CrossRefGoogle Scholar
  2. Daar ES, Moudgil T, Meyer RD, Ho DD (1991) Transient high levels of viremia in patients with primary human immunodeficiency virus type 1 infection. N Engl J Med 324:961–964CrossRefGoogle Scholar
  3. Finkel TH, Tudor-Williams G, Banda NK, Cotton MF, Curiel T, Monks C et al (1995) Apoptosis occurs predominantly in bystander cells and not in productively infected cells of HIV- and SIV-infected lymph nodes. Nat Med 1:129–134CrossRefGoogle Scholar
  4. Gayle HD, Hill GL (2001) Global impact of human immunodeficiency virus and AIDS. Clin Microbiol Rev 14:327–335CrossRefGoogle Scholar
  5. https://www.cdc.gov/actagainstaids/basics/whatishiv.htmlGoogle Scholar
  6. Lal S (2001) Surveillance of HIV/AIDS in India (editorial). Indian J Community Med 27:3–9Google Scholar
  7. National AIDS Control Organization (2007) Manual for quality standards for HIV Testing Laboratory IndiaGoogle Scholar
  8. National AIDS Control Organization (2013) Antiretroviral therapy guidelines for HIV-Infected Adults and Adolescents IndiaGoogle Scholar
  9. Paranjape RS (2005) Immunopathogenesis of HIV infection. Indian J Med Res 121:240–255PubMedGoogle Scholar
  10. Steinbrook R (2007) HIV in India-a complex epidemic. N Engl J Med 356:1089–1093CrossRefGoogle Scholar
  11. UNAIDS Global AIDS Update (2016)Google Scholar
  12. Walker CM, Moody DJ, Stites DP, Levy JA (1986) CD8+ lymphocytes can control HIV infection in vitro by suppressing virus replication. Science 234:1563–1566CrossRefGoogle Scholar
  13. World Health Organization (2016) Progress reportGoogle Scholar

Copyright information

© Springer Nature Singapore Pte Ltd. 2018

Authors and Affiliations

  • S. K. Arora
    • 1
  • Gurleen Mehta
    • 1
  1. 1.Department of ImmunopathologyPostgraduate Institute of Medical Education and ResearchChandigarhIndia

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