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Antibiotics and Antimicrobial Resistance

  • Varsha Gupta
  • Lipika Singhal
Chapter

Abstract

Antibiotics fundamentally revolutionized the practice of medicine and patient care, shifting the approach from diagnosis without intervening to a treatment-focused approach. However, the irrational use of antibiotic over the last seven decades has led to alarming clinical, environmental, and economic consequences. The judicious use of antibiotics limits the spread of antibiotic resistance as this strategy minimizes any unnecessary, inappropriate, or irrational use of antimicrobials. Most of the treating doctors hold good intentions of providing the best possible care to patients, and prescription of antibiotics is often considered a routine activity for achieving this by both patients and treating doctors. Researchers have found out that physician with high-volume practices and those who are in practice for longer are more likely to prescribe antibiotics inappropriately. On the other hand, patients have habit of repeating the prescription on their own, purchasing antibiotics without any prescription, or purchasing fewer units, all of which contribute to emergence of resistance. It would be rewarding to invest in seeking proper medical advice and further microbiological investigation in a patient who is suspected to have an infective etiology (bacterial) before instituting antibiotics. We have outlined the importance of rational use of antibiotics and good practices on part of both the doctor and the patients for effective containment of antimicrobial resistance.

Keywords

Antibiotics Antimicrobial resistance 

References

  1. Boucher HW, Talbot GH, Bradley JS, Edwards JE, Gilbert D, Rice LB et al (2009) Bad bugs, no drugs: no ESKAPE! An update from the Infectious Diseases Society of America. Clin Infect Dis 48:1–12CrossRefGoogle Scholar
  2. Braine T (2011) Race against time to develop new antibiotics. Bull World Health Organ 89:88–89CrossRefGoogle Scholar
  3. Butler CC, Rollnick S, Pill R, Maggs-Rapport F, Stott N (1998) Understanding the culture of prescribing: qualitative study of general practitioners’ and patients’ perceptions of antibiotics for sore throats. Br Med J 317:637–642CrossRefGoogle Scholar
  4. Cadieux G, Tamblyn R, Dauphinee D, Libman M (2007) Predictors of inappropriate antibiotic prescribing among primary care physicians. Can Med Assoc J 177:877–883CrossRefGoogle Scholar
  5. Circiumaru B, Baldock G, Cohen J (1999) A prospective study of fever in the intensive care unit. Intensive Care Med 25:668–673CrossRefGoogle Scholar
  6. Datta S, Wattal C, Goel N, Oberoi JK, Raveendran R, Prasad KJ (2012) A ten year analysis of multi-drug resistant blood stream infections caused by Escherichia coli & Klebsiella pneumoniae in a tertiary care hospital. Indian J Med Res 135:907–912PubMedPubMedCentralGoogle Scholar
  7. Dellit TH, Owens RC, McGowan JE Jr, Gerding DN, Weinstein RA, Burke JP et al (2007) Infectious Diseases Society of America and the Society for Healthcare Epidemiology of America guidelines for developing an institutional program to enhance antimicrobial stewardship. Clin Infect Dis 44:159–177CrossRefGoogle Scholar
  8. Ganguly NK, Arora NK, Chandy SJ, Fairoze MN, Gill JP, Gupta U et al (2011) Rationalizing antibiotic use to limit antibiotic resistance in India. Indian J Med Res 134:281–294PubMedGoogle Scholar
  9. Ghafur A, Mathai D, Muruganathan A, Jayalal JA, Kant R, Chaudhary D et al (2013) The Chennai declaration: a roadmap to tackle the challenge of antimicrobial resistance. Indian J Cancer 50:71–73CrossRefGoogle Scholar
  10. Infectious Diseases Society of America (2010) The 10 x ‘20 initiative: pursuing a global commitment to develop 10 new antibacterial drugs by 2020. Clin Infect Dis 50:1081–1083CrossRefGoogle Scholar
  11. Kotwani A, Wattal C, Katewa S, Joshi PC, Holloway K (2010) Factors influencing primary care physicians to prescribe antibiotics in Delhi India. Fam Pract 27:684–690CrossRefGoogle Scholar
  12. Marchaim D, Chopra T, Pogue JM, Perez F, Hujer AM, Rudin S et al (2011) Outbreak of colistin-resistant, carbapenem-resistant Klebsiella pneumoniae in metropolitan Detroit. Mich Antimicrob Agents Chemother 55:593–599CrossRefGoogle Scholar
  13. Pathak A, Mahadik K, Dhaneria SP, Sharma A, Eriksson B, Lundborg CS (2012) Surveillance of antibiotic consumption using the “focus of infection” approach in 2 hospitals in Ujjain, India. PLoS One 7:e38641 Epub 2012/06/21CrossRefGoogle Scholar
  14. Shlaes DM, Moellering RC Jr (2002) The United States Food and Drug Administration and the end of antibiotics. Clin Infect Dis 34:420–422CrossRefGoogle Scholar
  15. Sivagnanam G, Thirumalaikolundusubramanian P, Mohanasundaram J, Raaj AA, Namasivayam K, Rajaram S (2004) A survey on current attitude of practicing physicians upon usage of antimicrobial agents in southern part of India. Medscape Gen Med 6:1CrossRefGoogle Scholar
  16. Smith RD, Coast J, Millar MR (1996) Over-the-counter antimicrobials: the hidden costs of resistance. J Antimicrob Chemother 37:1031–1032CrossRefGoogle Scholar
  17. Spellberg B, Bartlett JG, Gilbert DN (2013) The future of antibiotics and resistance. N Engl J Med 368:299–302CrossRefGoogle Scholar
  18. Taylor RB, Shakoor O, Behrens RH (1995) Drug quality, a contributor to drug resistance? Lancet 346:122CrossRefGoogle Scholar
  19. The National Policy for Containment of Antimicrobial Resistance, India (2011) The National Centre for Disease Control, Director General of Health Services, Ministry of Health and Family Welfare, Government of India. Available from: nicd.nic.in/ab_policy.pdfGoogle Scholar
  20. Voss A, Ghafur A (2013) “The Chennai declaration” – Indian doctors’ fight against antimicrobial resistance. Antimicrob Resist Infect Control 2:7CrossRefGoogle Scholar
  21. World Health Organization (1985) The rational use of drugs report of the conference of experts [Internet]Google Scholar
  22. World Health Organization (2002) Perspectives on medicines. Promoting rational use of medicines: core components [Internet]. Available from: http://www.who.int/medicines/

Copyright information

© Springer Nature Singapore Pte Ltd. 2018

Authors and Affiliations

  • Varsha Gupta
    • 1
  • Lipika Singhal
    • 1
  1. 1.Department of MicrobiologyGovernment Medical College HospitalChandigarhIndia

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