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RNome in Cancer Therapy

  • Mansi Arora
  • Deepak Kaul
Chapter

Abstract

RNA is a versatile molecule that performs myriad roles in the cells. The differential expression of RNA is both indicative and causative for many pathological conditions, including cancer. Comprehensive studies over the past decade have been instrumental in highlighting the tissue-specific expression and dysregulation of ncRNA expression and function in cancers of different origins. While the miRNAs have been thoroughly studied and their targets verified, the contribution of other small and long ncRNAs in the field of cancer biology needs further exploration and validation. RNA-based therapeutics, though an exciting field, is still in its infancy, and there are many issues to be addressed before it reaches the clinics. In this chapter we will discuss the use of ncRNAs as diagnostic and prognostic biomarkers in different types of cancer. We further discuss their contribution to intrinsic and acquired chemoresistance of cancer cells and strategies for modulating the abundance and functions of both coding and non-coding RNAs in vivo. We also deliberate over the challenges and recent platforms for the delivery of therapeutic RNAs to the target site.

Keywords

Cancer biomarkers Chemotherapy resistance Delivery systems Non-coding RNAs Therapeutic RNAs 

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© Springer Nature Singapore Pte Ltd. 2018

Authors and Affiliations

  • Mansi Arora
    • 1
  • Deepak Kaul
    • 1
  1. 1.Department of Experimental Medicine and BiotechnologyPost Graduate Institute of Medical Education and ResearchChandigarhIndia

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