Cancer RNome: Evolution and Sustenance

  • Mansi Arora
  • Deepak Kaul


Neoplastic transformation is the result of accumulation of numerous genetic and epigenetic alterations that convert a normal cell into a cancer cell and confers it with an ability to proliferate and sustain indefinitely. The increasing acknowledgement of the non-coding RNAs (ncRNAs) as important players (as opposed to transcriptional noise) in the gene regulation has prompted the researchers across the globe to shift their focus from the “protein-coding genes” to ncRNAs. Several studies have explicitly demonstrated that ncRNAs are differentially expressed in cancer cells and their dysregulation is associated with malignant transformation. In this chapter, we discuss the various established and emerging hallmarks of cancer in light of ncRNAs that are intertwined with pathways of tumor progression. An increased understanding of this transcriptional complexity of cancer cells will definitely open up fresh avenues for cancer diagnosis and treatment.


Cancer hallmarks Cancer immunology Deregulated energetics Genomic instability ncRNA deregulation Replicative immortality 


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