Quality Assessment of Protein Tertiary Structures: Past, Present, and Future

  • Ankita Singh
  • Rahul Kaushik
  • B. JayaramEmail author


The quality assessment of protein structures is one of the most critical steps in the regime of reliable protein tertiary structure prediction. Post-conformational sampling of the decoys for a protein sequence and the scoring functions to perform quality assessment usually dictate the overall success of protein structure prediction. The field of protein structure quality assessment has achieved a chronological success over the years in differentiating between accurately and spuriously modeled structures. Implementation of physics-based, knowledge-based, and consensus approaches has contributed immensely in pushing the field to higher levels. Recently, the addition of metaserver approaches while integrating previously known methodologies has further pushed the field of protein structure quality assessment to a more reliable zone. Here, we described some of the tools/softwares/servers which implements diverse parameters to quantify the accuracy of modeled protein structures.


Protein structure prediction Modeled structure accuracies Error estimation Quality assessment RMSD MQAP 



Support to the Supercomputing Facility for Bioinformatics & Computational Biology (SCFBio), IIT Delhi, from the Department of Biotechnology, Govt. of India, is gratefully acknowledged.


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© Springer Nature Singapore Pte Ltd. 2018

Authors and Affiliations

  1. 1.Supercomputing Facility for Bioinformatics & Computational BiologyIIT DelhiNew DelhiIndia
  2. 2.Department of Bioscience and BiotechnologyBanasthali VidyapithRajasthanIndia
  3. 3.Kusuma School of Biological SciencesIndian Institute of TechnologyNew DelhiIndia
  4. 4.Department of ChemistryIndian Institute of TechnologyNew DelhiIndia

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