Dermatologic Adverse Events from Cancer Treatments

  • Jennifer Wu
  • Alina Markova
  • Mario E. LacoutureEmail author


The incidences of adverse events to cancer treatments have increased as new treatments are being developed. Dermatologic adverse events (dAEs) strongly impact patients’ quality of life (QoL). Severe dAEs can result in dose reduction or discontinuation, which may compromise clinical outcomes and even lead to life-threatening conditions. Prevention, early diagnosis, and proper management of dAEs are crucial for optimizing anticancer response and maintaining QoL. This chapter addresses dAEs induced by cytotoxic and targeted therapies, radiotherapy, stem cell transplantation, immunotherapies, and CAR-T cell therapy. Proposed underling mechanisms and recommended treatment approaches for these dAEs are presented.


Dermatologic adverse event (dAE) Skin toxicity Chemotherapy Targeted therapy Immunotherapy Checkpoint inhibitor Immune-related adverse event (irAE) 



Activities of daily living


Adverse drug reactions


Androgenetic alopecia


Actinic keratoses

CAR-T Cell

Chimeric antigen receptor-modified T lymphocytes


Chemotherapy-induced alopecia


Combination of dabrafenib with trametinib


Cytokine release syndrome


Cytotoxic T lymphocyte antigen-4


Drug reaction with eosinophilia and systemic symptoms


Epidermal growth factor receptor


Food and Drug Administration Adverse Event Reporting System






Graft versus host disease


Hand-foot skin reaction


Hematopoietic stem cell transplantation


Immune checkpoint inhibitors


Immediate hypersensitivity reactions


Immune-related adverse events


Immune-related bullous pemphigoid


Janus kinase inhibitors




Multi-targeted kinase inhibitors


Mycophenolate mofetil


Maculopapular rash


Methicillin-sensitive Staphylococcus aureus


Narrow band ultraviolet B


Non-small cell lung cancer


Nasal vestibulitis


persistent CIA


Pegylated liposomal doxorubicin


Papulopustular eruption


Quality of life


Radiation dermatitis


Severe cutaneous adverse reactions


Squamous cell carcinomas


Systemic calcineurin inhibitors


Stevens-Johnson syndrome/toxic epidermal necrolysis


Seborrheic keratoses


Topical calcineurin inhibitors


T cell receptor


World Health Organization



We would like to thank Ms. Bernadette Murphy for clinical photography.


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Copyright information

© Springer Nature Singapore Pte Ltd. 2019

Authors and Affiliations

  • Jennifer Wu
    • 1
    • 2
    • 3
  • Alina Markova
    • 1
  • Mario E. Lacouture
    • 1
    Email author
  1. 1.Dermatology Service, Department of MedicineMemorial Sloan Kettering Cancer CenterNew YorkUSA
  2. 2.Department of Dermatology, Drug Hypersensitivity Clinical and Research CenterChang Gung Memorial HospitalTaipeiTaiwan
  3. 3.College of MedicineChang Gung UniversityTaoyuanTaiwan

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