PIK3-AKT and Its Role in Pancreatic Cancer

  • Saimila Momin
  • Ganji Purnachandra NagarajuEmail author


The pancreas plays an important role in our body to help with maintaining and regulating homeostatic conditions. One of the cellular pathways that play a major role in pancreatic cell growth and division is the phosphatidylinositol-3-kinase-AKT pathway. According to current research studies, even the smallest changes to the phosphatidylinositol-3-kinase-AKT can cause abnormal cellular growth leading to the development of cancerous cells. Currently, there are many treatment options which are targeting the PI3K-AKT signaling pathway. This chapter examines the function of phosphatidylinositol-3-kinase-AKT pathway in pancreatic cancer and discusses current research studies that focus on potential treatment options.


Pancreatic cancer Growth PI-3K AKT 


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© Springer Nature Singapore Pte Ltd. 2018

Authors and Affiliations

  1. 1.Department of Hematology and Medical Oncology, Winship Cancer InstituteEmory UniversityAtlantaUSA
  2. 2.Department of Hematology and Medical Oncology, School of Medicine, Winship Cancer InstituteEmory UniversityAtlantaUSA

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