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Diabetes in Liver Disease

  • Takumi KawaguchiEmail author
  • Dan Nakano
  • Takuji Torimura
Chapter

Abstract

A high prevalence of diabetes mellitus has been reported in patients with chronic liver disease (CLD). Increasing evidence suggests that diabetes mellitus and its treatment have a significant impact on the clinical course of CLD. This review summarized the prevalence, diagnosis, and mechanisms of diabetes mellitus in patients with CLD. We also reviewed the clinical impact and therapeutic strategy for diabetes mellitus in patients with CLD. Recent progress using antidiabetic medication in non-alcoholic fatty liver disease/non-alcoholic steatohepatitis and hepatocellular carcinoma was also discussed.

Keywords

Insulin resistance Hepatitis C virus Non-alcoholic fatty liver disease Steatohepatitis Hepatoma Dipeptidyl peptidase-4inhibitor Sodium glucose cotransporter 2 inhibitor 

Abbreviations

AMPK

AMP-activated kinase

CGMS

continuous glucose monitoring system

CI

confidence interval

CLD

chronic liver disease

DPP4

dipeptidyl peptidase IV

HbA1c

glycated hemoglobin

HBV

hepatitis B virus

HCC

hepatocellular carcinoma

HCV

hepatitis C virus

HR

hazard ratio

IGF-1

insulin-like growth factor-1

IGT

impaired glucose tolerance

Loxl2

lysyl oxidase like 2

MAPK

mitogen-activated protein kinase

NAFLD

non-alcoholic fatty liver disease

OR

odds ratio

PNPLA3

patatin-like phospholipase domain-containing 3

QOL

quality of life

SGLT2

sodium glucose cotransporter 2

VLDL

very-low-density lipoprotein

Notes

Conflict of Interest Statement

All authors disclose no conflicts.

Financial Support

This work was supported by JSPS Grant-in-Aid for Scientific Research (C) JP17K09444.

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© Springer Nature Singapore Pte Ltd. 2019

Authors and Affiliations

  1. 1.Division of Gastroenterology, Department of MedicineKurume University School of MedicineKurumeJapan

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