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Alcohol-Induced DNA Injury in Esophageal Squamous Cell Carcinoma

  • Masashi Tamaoki
  • Yusuke Amanuma
  • Shinya Ohashi
  • Manabu MutoEmail author
Chapter

Abstract

Alcohol consumption is a major risk factor for esophageal squamous cell carcinoma. Acetaldehyde, a highly reactive compound that causes various types of DNA damage, plays a central role in alcohol-induced esophageal carcinogenesis. Acetaldehyde is mainly generated from the metabolism of ethanol by alcohol dehydrogenase 1B and is then detoxified to acetic acid by aldehyde dehydrogenase 2 (ALDH2). Alcohol consumption increases blood, saliva, and breath acetaldehyde levels, especially in individuals with inactive ALDH2 that are strongly associated with the risk of squamous cell carcinoma in the esophagus. In this chapter, we review recent studies of alcohol-mediated carcinogenesis in the squamous epithelium of the esophagus, focusing especially on acetaldehyde-induced DNA damage.

Keywords

Acetaldehyde DNA damage DNA adduct 

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Copyright information

© Springer Nature Singapore Pte Ltd. 2019

Authors and Affiliations

  • Masashi Tamaoki
    • 1
  • Yusuke Amanuma
    • 1
  • Shinya Ohashi
    • 1
  • Manabu Muto
    • 1
    Email author
  1. 1.Department of Therapeutic Oncology, Graduate School of MedicineKyoto UniversityKyotoJapan

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