Muscle Atrophy pp 347-368 | Cite as

The Molecular Mechanisms and Prevention Principles of Muscle Atrophy in Aging

  • Yu Zhang
  • Xiangbin Pan
  • Yi Sun
  • Yong-jian Geng
  • Xi-Yong Yu
  • Yangxin Li
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 1088)


Muscle atrophy in aging is characterized by progressive loss of muscle mass and function. Muscle mass is determined by the balance of synthesis and degradation of protein, which are regulated by several signaling pathways such as ubiquitin-proteasome system, autophagy-lysosome systems, oxidative stress, proinflammatory cytokines, hormones, and so on. Sufficient nutrition can enhance protein synthesis, while exercise can improve the quality of life in the elderly. This chapter will discuss the epidemiology, pathogenesis, as well as the current treatment for aging-induced muscular atrophy.


Muscle atrophy Aging Prevalence Mechanisms Pathophysiological effects Treatments 



This work was supported by a Jiangsu Province Key Scientific and Technological Project (BE2016669), a Suzhou Science and Technology Project (SS201665), Jiangsu Province Peak of Talent in Six Industries (BU24600117), Jiangsu Province Key Discipline/Laboratory of Medicine (XK201118), and the Priority Academic Program Development of Jiangsu Higher Education Institutions (PAPD).

Conflict of Interest

The authors declare no conflict of interest.


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Copyright information

© Springer Nature Singapore Pte Ltd. 2018

Authors and Affiliations

  • Yu Zhang
    • 1
  • Xiangbin Pan
    • 2
  • Yi Sun
    • 3
  • Yong-jian Geng
    • 4
  • Xi-Yong Yu
    • 5
  • Yangxin Li
    • 1
  1. 1.Institute for Cardiovascular Science & Department of Cardiovascular SurgeryFirst Affiliated Hospital of Soochow UniversitySuzhouPeople’s Republic of China
  2. 2.Department of Cardiac SurgeryFuwai HospitalBeijingPeople’s Republic of China
  3. 3.Fuwai Yunnan Cardiovascular HospitalKunmingPeople’s Republic of China
  4. 4.University of TexasHoustonUSA
  5. 5.Guangzhou Medical UniversityGuangzhouPeople’s Republic of China

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