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Heart Genomics pp 333-336 | Cite as

Warfarin and Its Pharmacogenomic Study

  • Shuiping Dai
Chapter
Part of the Translational Bioinformatics book series (TRBIO, volume 16)

Abstract

Warfarin as an anticoagulant is clinically prescribed to prevent blood clot formation. Genetic variants affect Warfarin response through pharmacokinetic and pharmacodynamic effects, which could account partially for the interracial difference to Warfarin. Warfarin activity is determined partially by the polymorphism in two genes, VKOPC1 and CYP2C9. Although the clinical application of pharmacogenomic information is controversial, the future gene sequencing and functional characterization of common genetic variation based on individual’s genetic information would provide a useful tool for precision medication.

Keyword

Warfarin Anticoagulant Pharmacogenomics 

Notes

Acknowledgment

The author would like to thank Dr. Xiaobo Wu and Dr. Ming Liu for constructive criticism and helps.

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Copyright information

© Springer Nature Singapore Pte Ltd. 2018

Authors and Affiliations

  • Shuiping Dai
    • 1
  1. 1.University of Wisconsin Hospital and ClinicsMadisonUSA

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